HU900394D0 - Process for producing a new compound of medical effect and pharmaceutical preparatives containing it - Google Patents

Process for producing a new compound of medical effect and pharmaceutical preparatives containing it

Info

Publication number
HU900394D0
HU900394D0 HU90394A HU39489A HU900394D0 HU 900394 D0 HU900394 D0 HU 900394D0 HU 90394 A HU90394 A HU 90394A HU 39489 A HU39489 A HU 39489A HU 900394 D0 HU900394 D0 HU 900394D0
Authority
HU
Hungary
Prior art keywords
producing
new compound
medical effect
preparatives containing
pharmaceutical preparatives
Prior art date
Application number
HU90394A
Other languages
Hungarian (hu)
Other versions
HUT58310A (en
Inventor
Ronald Gammill
Thomas M Judge
Joel Morris
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HU900394D0 publication Critical patent/HU900394D0/en
Publication of HUT58310A publication Critical patent/HUT58310A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/201,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU90394A 1988-12-21 1989-12-15 Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them HUT58310A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28779688A 1988-12-21 1988-12-21

Publications (2)

Publication Number Publication Date
HU900394D0 true HU900394D0 (en) 1991-09-30
HUT58310A HUT58310A (en) 1992-02-28

Family

ID=23104392

Family Applications (2)

Application Number Title Priority Date Filing Date
HU90394A HUT58310A (en) 1988-12-21 1989-12-15 Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them
HU95P/P00411P HU211339A9 (en) 1988-12-21 1995-06-23 Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU95P/P00411P HU211339A9 (en) 1988-12-21 1995-06-23 Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

Country Status (8)

Country Link
EP (1) EP0459983A1 (en)
JP (1) JPH04502322A (en)
AU (1) AU634994B2 (en)
DK (1) DK118791D0 (en)
FI (1) FI912995A0 (en)
HU (2) HUT58310A (en)
RU (1) RU2118321C1 (en)
WO (1) WO1990006921A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019707A2 (en) * 1990-06-20 1991-12-26 The Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
KR920702353A (en) * 1990-06-29 1992-09-03 로버트 에이. 아미테이지 2-amino-6-phenyl-4H-pyran-4-one for the treatment of atherosclerosis and thrombosis
US5302613A (en) * 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
CA2182932A1 (en) * 1995-08-10 1997-02-11 Koju Watanabe Chromone derivative, process for preparing same and pharmaceutical composition
DE19850131A1 (en) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon and chromanone derivatives
AU3704400A (en) * 1999-03-04 2000-09-21 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
DK1257537T3 (en) 2000-01-24 2007-10-01 Astrazeneca Ab Therapeutic morpholino-substituted compounds
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
JP4664597B2 (en) 2002-04-17 2011-04-06 サイトキネティクス・インコーポレーテッド Compounds, compositions and methods
AU2003252025A1 (en) 2002-07-17 2004-02-02 Cytokinetics, Inc. Compounds, compositions, and methods
JP4646626B2 (en) * 2002-08-16 2011-03-09 アストラゼネカ アクチボラグ Inhibition of phosphoinositide 3-kinase β
CN101260104A (en) * 2002-08-16 2008-09-10 阿斯利康(瑞典)有限公司 Inhibition of phosphoinositide 3-kinase beta
CA2525383C (en) 2003-06-06 2012-03-06 Arexis Ab Use of heterocyclic compounds as scce inhibitors
CN100518740C (en) * 2003-06-06 2009-07-29 阿里克斯股份公司 Use of heterocyclic compounds as SCCE inhibitors
US7429660B2 (en) 2003-08-13 2008-09-30 Kudos Pharmaceuticals Limited ATM inhibitors
TR200808208T1 (en) 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Suppression of an immune response or treatment of a proliferative disease
US20070238731A1 (en) 2004-09-20 2007-10-11 Kudos Pharmaceuticals Limited Dna-Pk Inhibitors
TW200638938A (en) 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR053358A1 (en) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd DNA INHIBITORS - PK
WO2009038064A1 (en) * 2007-09-19 2009-03-26 Institute Of Medicinal Molecular Design, Inc. Heterocyclic derivative having inhibitory activity on type-i 11β-hydroxysteroid dehydrogenase
AU2009295948B2 (en) * 2008-09-29 2013-12-05 GlaxoSmithKline, LLC Quinazolinone, quinolone and related analogs as sirtuin modulators
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
US8530470B2 (en) 2011-04-13 2013-09-10 Astrazeneca Ab Chromenone derivatives
RU2468018C1 (en) * 2011-10-06 2012-11-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Method of producing 4-oxo-4h-chromene derivatives containing vinyl and enamine groups
EP2808322B1 (en) * 2012-01-26 2017-08-23 Daiichi Sankyo Company, Limited Chromone derivative having osteogenesis promoting effect
TW201412727A (en) * 2012-08-24 2014-04-01 Daiichi Sankyo Co Ltd Chromone derivative having linear side chain
KR102222346B1 (en) 2013-03-04 2021-03-02 아스트라제네카 아베 Combination treatment
CN108947952B (en) * 2017-05-24 2021-09-21 中国医学科学院药物研究所 2-substituted amino-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ketone compound and preparation method and application thereof
CN108929329B (en) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-azacyclo-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ones
AR121719A1 (en) 2020-04-03 2022-06-29 Petra Pharma Corp ALLESTERIC INHIBITORS OF CHROMENONE OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES
IL307950A (en) 2021-05-03 2023-12-01 Petra Pharma Corp Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
TWI829179B (en) 2021-05-27 2024-01-11 美商佩特拉製藥公司 Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
TW202329930A (en) 2021-09-30 2023-08-01 美商佩特拉製藥公司 Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2205913A1 (en) * 1972-02-08 1973-08-16 Thiemann Chem Pharm Fab 2-AMINO-3-HYDROXY-CHROMONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE2555290A1 (en) * 1975-12-09 1977-06-16 Boehringer Mannheim Gmbh NEW BENZOPYRONE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
US4412071A (en) * 1982-05-17 1983-10-25 The Upjohn Company Antiatherosclerotic compositions
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
IL89840A (en) * 1988-04-06 1996-10-31 Lipha Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them

Also Published As

Publication number Publication date
AU4807190A (en) 1990-07-10
AU634994B2 (en) 1993-03-11
FI912995A0 (en) 1991-06-19
JPH04502322A (en) 1992-04-23
RU2118321C1 (en) 1998-08-27
DK118791A (en) 1991-06-19
EP0459983A1 (en) 1991-12-11
WO1990006921A1 (en) 1990-06-28
DK118791D0 (en) 1991-06-19
HUT58310A (en) 1992-02-28
HU211339A9 (en) 1995-11-28

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Legal Events

Date Code Title Description
DFD9 Temporary prot. cancelled due to non-payment of fee