DK1179005T3 - Steroidforbindelser med en C17-alkyl-sidekæde og en aromatisk A-ring til anvendelse i terapi - Google Patents
Steroidforbindelser med en C17-alkyl-sidekæde og en aromatisk A-ring til anvendelse i terapiInfo
- Publication number
- DK1179005T3 DK1179005T3 DK00927569T DK00927569T DK1179005T3 DK 1179005 T3 DK1179005 T3 DK 1179005T3 DK 00927569 T DK00927569 T DK 00927569T DK 00927569 T DK00927569 T DK 00927569T DK 1179005 T3 DK1179005 T3 DK 1179005T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- group
- hydrogen atom
- hydroxyl
- therapy
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 title abstract 2
- -1 Steroid compounds Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9910934.0A GB9910934D0 (en) | 1999-05-11 | 1999-05-11 | Chemical compounds |
| PCT/GB2000/001813 WO2000068246A1 (en) | 1999-05-11 | 2000-05-11 | Steroid compounds with a c17-alkyl side chain and an aromatic a-ring for use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1179005T3 true DK1179005T3 (da) | 2004-03-01 |
Family
ID=10853250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00927569T DK1179005T3 (da) | 1999-05-11 | 2000-05-11 | Steroidforbindelser med en C17-alkyl-sidekæde og en aromatisk A-ring til anvendelse i terapi |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6881730B1 (enExample) |
| EP (1) | EP1179005B1 (enExample) |
| JP (1) | JP2002544137A (enExample) |
| KR (1) | KR100690040B1 (enExample) |
| CN (1) | CN1158297C (enExample) |
| AT (1) | ATE254629T1 (enExample) |
| AU (1) | AU779743B2 (enExample) |
| CA (1) | CA2373443A1 (enExample) |
| CZ (1) | CZ297316B6 (enExample) |
| DE (1) | DE60006665T2 (enExample) |
| DK (1) | DK1179005T3 (enExample) |
| ES (1) | ES2207509T3 (enExample) |
| GB (1) | GB9910934D0 (enExample) |
| HK (1) | HK1046001B (enExample) |
| HU (1) | HUP0201047A3 (enExample) |
| IL (2) | IL146442A0 (enExample) |
| NO (1) | NO319949B1 (enExample) |
| NZ (1) | NZ515482A (enExample) |
| PT (1) | PT1179005E (enExample) |
| WO (1) | WO2000068246A1 (enExample) |
| ZA (1) | ZA200109272B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
| US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
| NZ523042A (en) * | 2000-05-11 | 2004-05-28 | Res Inst Medicine Chem | 2-substituted pregna-1, 3, 5 (10) -triene and chola-1, 3, 5 (10)-triene derivatives and their biological activity |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| JP2004537499A (ja) * | 2000-11-27 | 2004-12-16 | エントレメッド インコーポレイテッド | 抗血管新生薬 |
| WO2002092100A1 (en) * | 2001-05-11 | 2002-11-21 | Marsden, John, Christopher | 17-(c(ch3) (ch2) o-3c (r4, r5) n (r6, r7))-substituted 19-nor-pregna-1, 3, 5(10)-triene derivatives and their medical use |
| AU2004275693A1 (en) | 2003-05-28 | 2005-04-07 | Entremed, Inc. | Antiangiogenic agents |
| JP2007529426A (ja) | 2004-03-12 | 2007-10-25 | エントレメッド インコーポレイテッド | 抗血管新生薬 |
| CA2646065C (en) | 2006-03-20 | 2014-01-14 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| NZ581081A (en) * | 2007-06-19 | 2012-12-21 | Kythera Biopharmaceuticals Inc | Synthetic deoxycholic acid (dca) or an ester, hydroxamale, or hydroxyamide thereof |
| US8242294B2 (en) | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| JOP20180077A1 (ar) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| WO2013036835A1 (en) * | 2011-09-08 | 2013-03-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| RS67266B1 (sr) | 2013-03-13 | 2025-10-31 | Sage Therapeutics Inc | Neuroaktivni steroidi i postupci za njihovu upotrebu |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| BR112018000129B1 (pt) | 2015-07-06 | 2024-01-09 | Sage Therapeutics, Inc | Compostos oxiesteróis, seus usos e composição farmacêutica |
| SMT202100476T1 (it) | 2015-07-06 | 2021-09-14 | Sage Therapeutics Inc | Ossisteroli e metodi di uso degli stessi |
| JP6882996B2 (ja) | 2015-07-06 | 2021-06-02 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびそれらの使用の方法 |
| SI3436022T1 (sl) | 2016-04-01 | 2022-08-31 | Sage Therapeutics, Inc. | Oksisteroli in postopki za uporabo le-teh |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| ES2884071T3 (es) | 2016-07-07 | 2021-12-10 | Sage Therapeutics Inc | 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA |
| MX392270B (es) | 2016-09-30 | 2025-03-24 | Sage Therapeutics Inc | Oxisteroles sustituidos en c7 y metodos de uso de los mismos. |
| EP4105223B1 (en) | 2016-10-18 | 2025-04-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| CN110267966B (zh) | 2016-10-18 | 2022-07-08 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
| CN115040524A (zh) * | 2022-07-27 | 2022-09-13 | 深圳市中西医结合医院 | 4-胆甾烯-3-酮用于治疗多发性骨髓瘤骨病的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562260A (en) * | 1965-08-23 | 1971-02-09 | Ormonoterapia Richter Spa | 2-carbonyl-estratrienes and method of their preparation |
| GB1267915A (en) * | 1968-05-24 | 1972-03-22 | Glaxo Lab Ltd | Ring a-substituted ring a-aromatic steroids |
| FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| JP2623285B2 (ja) * | 1988-03-09 | 1997-06-25 | 雪印乳業株式会社 | ２（３―ハイドロキシ―１，３，５（１０）―エストリエン―１７―イル）プロピオン酸の製造法 |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
| US6967195B2 (en) * | 2000-05-11 | 2005-11-22 | Research Institute For Medicine And Chemistry, Inc. | 2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10) triene derivatives and their biological activity |
-
1999
- 1999-05-11 GB GBGB9910934.0A patent/GB9910934D0/en not_active Ceased
-
2000
- 2000-05-11 CN CNB008095175A patent/CN1158297C/zh not_active Expired - Fee Related
- 2000-05-11 HU HU0201047A patent/HUP0201047A3/hu unknown
- 2000-05-11 DE DE60006665T patent/DE60006665T2/de not_active Expired - Fee Related
- 2000-05-11 NZ NZ515482A patent/NZ515482A/en unknown
- 2000-05-11 ES ES00927569T patent/ES2207509T3/es not_active Expired - Lifetime
- 2000-05-11 CA CA002373443A patent/CA2373443A1/en not_active Abandoned
- 2000-05-11 AU AU45960/00A patent/AU779743B2/en not_active Ceased
- 2000-05-11 EP EP00927569A patent/EP1179005B1/en not_active Expired - Lifetime
- 2000-05-11 CZ CZ20014049A patent/CZ297316B6/cs not_active IP Right Cessation
- 2000-05-11 WO PCT/GB2000/001813 patent/WO2000068246A1/en not_active Ceased
- 2000-05-11 AT AT00927569T patent/ATE254629T1/de not_active IP Right Cessation
- 2000-05-11 KR KR1020017014382A patent/KR100690040B1/ko not_active Expired - Fee Related
- 2000-05-11 PT PT00927569T patent/PT1179005E/pt unknown
- 2000-05-11 JP JP2000616220A patent/JP2002544137A/ja active Pending
- 2000-05-11 IL IL14644200A patent/IL146442A0/xx active IP Right Grant
- 2000-05-11 HK HK02105910.4A patent/HK1046001B/en not_active IP Right Cessation
- 2000-05-11 DK DK00927569T patent/DK1179005T3/da active
-
2001
- 2001-11-09 ZA ZA200109272A patent/ZA200109272B/xx unknown
- 2001-11-11 IL IL146442A patent/IL146442A/en not_active IP Right Cessation
- 2001-11-12 NO NO20015520A patent/NO319949B1/no not_active IP Right Cessation
-
2003
- 2003-05-11 US US09/926,491 patent/US6881730B1/en not_active Expired - Fee Related
-
2005
- 2005-02-11 US US11/055,620 patent/US20050171075A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU779743B2 (en) | 2005-02-10 |
| NZ515482A (en) | 2004-05-28 |
| DE60006665D1 (de) | 2003-12-24 |
| JP2002544137A (ja) | 2002-12-24 |
| EP1179005B1 (en) | 2003-11-19 |
| HK1046001B (en) | 2004-12-24 |
| US6881730B1 (en) | 2005-04-19 |
| DE60006665T2 (de) | 2004-10-07 |
| NO20015520D0 (no) | 2001-11-12 |
| NO319949B1 (no) | 2005-10-03 |
| CN1158297C (zh) | 2004-07-21 |
| IL146442A0 (en) | 2002-07-25 |
| US20050171075A1 (en) | 2005-08-04 |
| AU4596000A (en) | 2000-11-21 |
| HK1046001A1 (en) | 2002-12-20 |
| ZA200109272B (en) | 2003-02-26 |
| GB9910934D0 (en) | 1999-07-14 |
| EP1179005A1 (en) | 2002-02-13 |
| KR20020013542A (ko) | 2002-02-20 |
| HUP0201047A3 (en) | 2003-07-28 |
| KR100690040B1 (ko) | 2007-03-09 |
| CZ20014049A3 (cs) | 2002-04-17 |
| IL146442A (en) | 2006-10-05 |
| CZ297316B6 (cs) | 2006-11-15 |
| CA2373443A1 (en) | 2000-11-16 |
| PT1179005E (pt) | 2004-04-30 |
| WO2000068246A1 (en) | 2000-11-16 |
| CN1358193A (zh) | 2002-07-10 |
| HUP0201047A2 (en) | 2002-08-28 |
| ES2207509T3 (es) | 2004-06-01 |
| ATE254629T1 (de) | 2003-12-15 |
| NO20015520L (no) | 2002-01-09 |
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