DK1140969T3 - Bindevævsvækstfaktorfragmenter og fremgangsmåder og anvendelser deraf - Google Patents
Bindevævsvækstfaktorfragmenter og fremgangsmåder og anvendelser derafInfo
- Publication number
- DK1140969T3 DK1140969T3 DK99965256T DK99965256T DK1140969T3 DK 1140969 T3 DK1140969 T3 DK 1140969T3 DK 99965256 T DK99965256 T DK 99965256T DK 99965256 T DK99965256 T DK 99965256T DK 1140969 T3 DK1140969 T3 DK 1140969T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- ctgf
- growth factor
- connective tissue
- tissue growth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11224098P | 1998-12-14 | 1998-12-14 | |
US11224198P | 1998-12-14 | 1998-12-14 | |
PCT/US1999/029652 WO2000035936A1 (en) | 1998-12-14 | 1999-12-14 | Connective tissue growth factor fragments and methods and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1140969T3 true DK1140969T3 (da) | 2007-09-17 |
Family
ID=26809725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99965256T DK1140969T3 (da) | 1998-12-14 | 1999-12-14 | Bindevævsvækstfaktorfragmenter og fremgangsmåder og anvendelser deraf |
Country Status (16)
Country | Link |
---|---|
US (3) | US6492129B1 (zh) |
EP (2) | EP1140969B1 (zh) |
JP (2) | JP4634614B2 (zh) |
KR (2) | KR100664625B1 (zh) |
CN (3) | CN1660911A (zh) |
AT (2) | ATE391724T1 (zh) |
AU (3) | AU773278B2 (zh) |
CA (2) | CA2354456A1 (zh) |
CY (1) | CY1108860T1 (zh) |
DE (2) | DE69936315T2 (zh) |
DK (1) | DK1140969T3 (zh) |
ES (2) | ES2304811T3 (zh) |
HK (2) | HK1041268B (zh) |
MX (1) | MXPA01005949A (zh) |
PT (1) | PT1140969E (zh) |
WO (2) | WO2000035936A1 (zh) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026299B2 (en) | 1994-07-12 | 2006-04-11 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
NZ271488A (en) | 1994-07-12 | 1998-01-26 | Human Genome Sciences Inc | Connective tissue growth factor-2 (ctgf-2) |
WO2000035936A1 (en) * | 1998-12-14 | 2000-06-22 | University Of Miami | Connective tissue growth factor fragments and methods and uses thereof |
US7115390B1 (en) * | 1998-12-14 | 2006-10-03 | Fibrogen, Inc. | Connective tissue growth factor fragments and methods and uses thereof |
AU2001276868A1 (en) * | 2000-07-11 | 2002-01-21 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
US20030113816A1 (en) * | 2001-09-18 | 2003-06-19 | Weitz Stephen L. | Methods of assaying connective tissue growth factor |
WO2003035083A1 (de) * | 2001-10-26 | 2003-05-01 | Ribopharma Ag | Medikament zur behandlung einer fibrotischen erkrankung durch rna interferenz |
US6965025B2 (en) | 2001-12-10 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of connective tissue growth factor expression |
EP1463531B1 (en) * | 2001-12-11 | 2011-09-28 | Fibrogen, Inc. | Methods for inhibiting ocular processes |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US7405274B2 (en) | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
US20050153395A1 (en) * | 2003-09-29 | 2005-07-14 | Children's Hospital Inc. | Unique integrin binding site in connective tissue growth factor (CTGF) |
EP1687410A4 (en) | 2003-10-07 | 2008-04-09 | Isis Pharmaceuticals Inc | ANTISENSE OLIGONUCLEOTIDES OPTIMIZED TO TARGET THE KIDNEY |
US20050191653A1 (en) | 2003-11-03 | 2005-09-01 | Freier Susan M. | Modulation of SGLT2 expression |
GB0326778D0 (en) * | 2003-11-18 | 2003-12-24 | Imp College Innovations Ltd | Biological materials and uses thereof |
DK1715890T3 (da) | 2004-02-11 | 2008-11-17 | Fibrogen Inc | CTGF som mål for mikroalbuminuriterapi hos patienter med diabetisk nefropati |
ZA200607588B (en) * | 2004-02-11 | 2008-05-28 | Fibrogen Inc | CTGF as target for the therapy of diabetic nephropathy |
US20050271670A1 (en) * | 2004-04-28 | 2005-12-08 | Spong Suzanne M | Treatments for cancer |
WO2005116194A1 (ja) * | 2004-05-25 | 2005-12-08 | Riken | 試験管内筋繊維形成のための筋芽細胞又は筋芽細胞様細胞培養法 |
EP1692935A1 (en) * | 2005-02-22 | 2006-08-23 | Boehringer Ingelheim International GmbH | Transgenic animal as a model for human pulmonary disease |
AU2006244148A1 (en) | 2005-05-05 | 2006-11-16 | Fibrogen, Inc. | Cardiovascular disease therapies |
PL1954718T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał |
DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
WO2008027288A2 (en) | 2006-08-30 | 2008-03-06 | The Trustees Of Columbia University In The City Of New York | Treatment for craniosynostosis by growth factor delivery |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8617877B2 (en) * | 2007-11-02 | 2013-12-31 | The Johns Hopkins University | Cardiac stem cell and myocyte secreted paracrine factors |
US8252762B2 (en) | 2008-08-25 | 2012-08-28 | Excaliard Pharmaceuticals, Inc. | Antisense oligonucleotides directed against connective tissue growth factor and uses thereof |
WO2010027830A2 (en) * | 2008-08-25 | 2010-03-11 | Excaliard Pharmaceuticals, Inc. | Methods for modulation of connective tissue growth factor expression by administering antisense oligonucleotides through a delivery system so as to reduce scarring from wound healing and threat fibrotic diseases |
US8946172B2 (en) | 2008-08-25 | 2015-02-03 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to CTGF |
EP3336188B1 (en) | 2008-09-22 | 2020-05-06 | Phio Pharmaceuticals Corp. | Reduced size self-delivering rnai compounds |
CN102666587A (zh) | 2009-07-02 | 2012-09-12 | 菲布罗根有限公司 | 用于治疗肌营养不良的方法 |
WO2011056234A1 (en) | 2009-11-06 | 2011-05-12 | Fibrogen, Inc. | Treatment for radiation-induced disorders |
CN106074591B (zh) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
IL265674B2 (en) | 2010-03-24 | 2024-05-01 | Phio Pharm Corp | Rana disorder in cutaneous and fibrotic symptoms |
JP2013523182A (ja) | 2010-04-15 | 2013-06-17 | アボット・ラボラトリーズ | アミロイドベータ結合タンパク質 |
KR101249041B1 (ko) | 2010-04-28 | 2013-03-29 | 포항공과대학교 산학협력단 | 결합조직 성장인자를 이용한 약학적 조성물 |
EP2603524A1 (en) | 2010-08-14 | 2013-06-19 | AbbVie Inc. | Amyloid-beta binding proteins |
US20140134181A1 (en) | 2010-11-05 | 2014-05-15 | Kenneth E. Lipson | Treatment Method For Lung Remodeling Diseases |
WO2012100262A1 (en) | 2011-01-21 | 2012-07-26 | Fibrogen, Inc. | Therapeutic method using anti - ctgf antibody |
JP6177692B2 (ja) * | 2011-02-02 | 2017-08-09 | エクスカリアード・ファーマシューティカルズ,インク | 結合組織増殖因子(ctgf)をターゲティングするアンチセンス化合物を用いた、ケロイドまたは肥厚性瘢痕の治療法 |
KR20140107507A (ko) | 2011-12-22 | 2014-09-04 | 아스텔라스세이야쿠 가부시키가이샤 | 신규 항 인간 ctgf 항체 |
US9480449B2 (en) | 2012-05-03 | 2016-11-01 | Fibrogen, Inc. | Methods for treating idiopathic pulmonary fibrosis |
US9132171B2 (en) | 2012-05-23 | 2015-09-15 | Wisconsin Alumni Research Foundation | Test of insulin as a drug to reduce restenosis of vessels |
US9631013B2 (en) | 2014-01-28 | 2017-04-25 | Fibrogen, Inc. | Therapeutic method for pancreatic cancer |
AU2016279897A1 (en) | 2015-06-15 | 2017-12-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and treating affective disorders |
CN109402127B (zh) * | 2018-09-29 | 2021-12-10 | 复旦大学附属眼耳鼻喉科医院 | 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用 |
CN111424035A (zh) * | 2020-04-13 | 2020-07-17 | 西南大学 | 基于家蚕丝腺表达具有生物学活性的人结缔组织生长因子的方法及其产品和应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US392024A (en) * | 1888-10-30 | Jjett | ||
US4906742A (en) * | 1986-07-31 | 1990-03-06 | Whitehead Institute For Biomedical Research | Encoding antigens of M. Leprae |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
FR2678283A1 (fr) * | 1991-06-25 | 1992-12-31 | Centre Nat Rech Scient | Sequences de nucleotides, sequences d'acides amines correspondantes, et leurs applications biologiques. |
US5408040A (en) * | 1991-08-30 | 1995-04-18 | University Of South Florida | Connective tissue growth factor(CTGF) |
US5770209A (en) * | 1991-08-30 | 1998-06-23 | University Of South Florida | Acceleration of wound healing using connective tissue growth factor |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
ES2136092T3 (es) * | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
US5596090A (en) * | 1992-07-24 | 1997-01-21 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human VCAM-1 RNA |
NZ271488A (en) * | 1994-07-12 | 1998-01-26 | Human Genome Sciences Inc | Connective tissue growth factor-2 (ctgf-2) |
US5789389A (en) * | 1995-03-17 | 1998-08-04 | Board Of Trustees Of University Of Illinois | BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs |
US5688915A (en) | 1995-06-01 | 1997-11-18 | The University Of Medicine And Dentistry Of New Jersey | Long term maintenance of lymphocytes in vitro |
WO1996039486A1 (en) * | 1995-06-05 | 1996-12-12 | Human Genome Sciences, Inc. | Human ccn-like growth factor |
EP0827742A1 (en) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
US5876730A (en) * | 1997-08-07 | 1999-03-02 | Childrens Hospital Research Foundation | Heparin-binding growth factor (HBGF) polypeptides |
EP1043335A4 (en) * | 1997-12-25 | 2005-08-31 | Japan Tobacco Inc | MONOCLONAL ANTIBODY AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND ITS MEDICAL APPLICATIONS |
WO1999042583A1 (en) | 1998-02-20 | 1999-08-26 | Zymogenetics, Inc. | Connective tissue growth factor homologs |
US6238921B1 (en) * | 1998-03-26 | 2001-05-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of human mdm2 expression |
US6348329B1 (en) * | 1998-11-06 | 2002-02-19 | Fibrogen, Inc. | Nucleic acids encoding rat connective tissue growth factor (CTGF) and methods of use |
WO2000035936A1 (en) * | 1998-12-14 | 2000-06-22 | University Of Miami | Connective tissue growth factor fragments and methods and uses thereof |
US7405274B2 (en) * | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
-
1999
- 1999-12-14 WO PCT/US1999/029652 patent/WO2000035936A1/en active IP Right Grant
- 1999-12-14 ES ES99966224T patent/ES2304811T3/es not_active Expired - Lifetime
- 1999-12-14 DE DE69936315T patent/DE69936315T2/de not_active Expired - Lifetime
- 1999-12-14 AT AT99966224T patent/ATE391724T1/de not_active IP Right Cessation
- 1999-12-14 JP JP2000588197A patent/JP4634614B2/ja not_active Expired - Fee Related
- 1999-12-14 WO PCT/US1999/029654 patent/WO2000035939A2/en active IP Right Grant
- 1999-12-14 DK DK99965256T patent/DK1140969T3/da active
- 1999-12-14 CN CN2004101024245A patent/CN1660911A/zh active Pending
- 1999-12-14 AU AU31211/00A patent/AU773278B2/en not_active Expired
- 1999-12-14 DE DE69938507T patent/DE69938507T2/de not_active Expired - Lifetime
- 1999-12-14 CA CA002354456A patent/CA2354456A1/en not_active Abandoned
- 1999-12-14 CA CA002354422A patent/CA2354422A1/en not_active Abandoned
- 1999-12-14 AT AT99965256T patent/ATE364617T1/de active
- 1999-12-14 KR KR1020017007367A patent/KR100664625B1/ko active IP Right Grant
- 1999-12-14 PT PT99965256T patent/PT1140969E/pt unknown
- 1999-12-14 MX MXPA01005949A patent/MXPA01005949A/es unknown
- 1999-12-14 AU AU21819/00A patent/AU775391B2/en not_active Expired
- 1999-12-14 US US09/461,688 patent/US6492129B1/en not_active Expired - Lifetime
- 1999-12-14 JP JP2000588194A patent/JP4722290B2/ja not_active Expired - Lifetime
- 1999-12-14 EP EP99965256A patent/EP1140969B1/en not_active Expired - Lifetime
- 1999-12-14 EP EP99966224A patent/EP1140964B1/en not_active Expired - Lifetime
- 1999-12-14 CN CNB998158747A patent/CN1187370C/zh not_active Expired - Lifetime
- 1999-12-14 CN CNB99815850XA patent/CN1170849C/zh not_active Expired - Lifetime
- 1999-12-14 KR KR1020017007410A patent/KR100664626B1/ko active IP Right Grant
- 1999-12-14 ES ES99965256T patent/ES2288321T3/es not_active Expired - Lifetime
-
2002
- 2002-04-09 HK HK02102627.5A patent/HK1041268B/zh not_active IP Right Cessation
- 2002-04-10 HK HK02102721.0A patent/HK1041005B/zh not_active IP Right Cessation
- 2002-12-09 US US10/315,568 patent/US7718177B2/en not_active Expired - Lifetime
-
2004
- 2004-08-20 AU AU2004205171A patent/AU2004205171B2/en not_active Expired
-
2007
- 2007-07-31 CY CY20071101018T patent/CY1108860T1/el unknown
-
2010
- 2010-04-06 US US12/755,367 patent/US20100190838A1/en not_active Abandoned
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