DE69031939D1 - Osteoinduktive zusammensetzungen - Google Patents

Osteoinduktive zusammensetzungen

Info

Publication number
DE69031939D1
DE69031939D1 DE69031939T DE69031939T DE69031939D1 DE 69031939 D1 DE69031939 D1 DE 69031939D1 DE 69031939 T DE69031939 T DE 69031939T DE 69031939 T DE69031939 T DE 69031939T DE 69031939 D1 DE69031939 D1 DE 69031939D1
Authority
DE
Germany
Prior art keywords
bmp
osteoinductive compositions
proteins
osteoinductive
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69031939T
Other languages
English (en)
Other versions
DE69031939T2 (de
Inventor
Elizabeth Wang
John Wozney
Vicki Rosen
Anthony Celeste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/370,547 external-priority patent/US5106748A/en
Priority claimed from US07/438,919 external-priority patent/US5141905A/en
Priority claimed from US07/490,033 external-priority patent/US5187076A/en
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of DE69031939D1 publication Critical patent/DE69031939D1/de
Application granted granted Critical
Publication of DE69031939T2 publication Critical patent/DE69031939T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69031939T 1989-03-28 1990-03-27 Osteoinduktive zusammensetzungen Expired - Lifetime DE69031939T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US32961089A 1989-03-28 1989-03-28
US34755989A 1989-05-04 1989-05-04
US37054989A 1989-06-23 1989-06-23
US37054489A 1989-06-23 1989-06-23
US07/370,547 US5106748A (en) 1986-07-01 1989-06-23 Dna sequences encoding 5 proteins
US43740989A 1989-11-15 1989-11-15
US07/438,919 US5141905A (en) 1986-07-01 1989-11-17 Dna sequences encoding bmp-7 proteins
US07/490,033 US5187076A (en) 1986-07-01 1990-03-07 DNA sequences encoding BMP-6 proteins
PCT/US1990/001630 WO1990011366A1 (en) 1989-03-28 1990-03-27 Osteoinductive compositions

Publications (2)

Publication Number Publication Date
DE69031939D1 true DE69031939D1 (de) 1998-02-19
DE69031939T2 DE69031939T2 (de) 1998-09-10

Family

ID=27575396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69031939T Expired - Lifetime DE69031939T2 (de) 1989-03-28 1990-03-27 Osteoinduktive zusammensetzungen

Country Status (8)

Country Link
EP (1) EP0429570B1 (de)
KR (1) KR100214740B1 (de)
AT (1) ATE162223T1 (de)
CA (1) CA2030518C (de)
DE (1) DE69031939T2 (de)
DK (1) DK0429570T3 (de)
ES (1) ES2113857T3 (de)
WO (1) WO1990011366A1 (de)

Families Citing this family (79)

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US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
ATE134647T1 (de) * 1988-04-08 1996-03-15 Stryker Corp Osteogene vorrichtungen
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
JP2845346B2 (ja) * 1989-10-17 1999-01-13 ストライカー・コーポレーション 骨形成具
EP0536186B1 (de) * 1990-05-16 2001-11-21 Genetics Institute, Inc. Knochen- und knorpel-bildung hervorrufende proteine
ATE253589T1 (de) * 1990-09-26 2003-11-15 Inst Genetics Llc Bmp-5-derivate
DK0643767T3 (da) * 1990-10-18 1999-04-26 Stryker Corp Osteogene peptider
WO1992007004A1 (en) * 1990-10-18 1992-04-30 Creative Biomolecules, Inc. Osteogenic protein
US5739107A (en) * 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
ZA923086B (en) * 1991-04-29 1993-10-28 South African Medical Research A delivery system for biologicaly active growth or morphogenetic factors and a method for preparing such delivery system
US5661007A (en) * 1991-06-25 1997-08-26 Genetics Institute, Inc. Bone morphogenetic protein-9 compositions
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
CA2116560C (en) * 1991-08-30 2002-01-08 Charles M. Cohen Morphogenic protein screening method
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
IT1259042B (it) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante
US5610021A (en) * 1992-02-21 1997-03-11 Creative Biomolecules, Inc. Compositions and methods for identification and use of soluble complex forms of osteogenic proteins
DK0653942T3 (da) * 1992-07-31 2003-10-20 Curis Inc Morphogen-induceret nerve-regenerering og -reparation
US6333168B1 (en) 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6764994B1 (en) 1993-08-10 2004-07-20 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Growth/differential factor of the TGF-B family
DE4420157B4 (de) * 1993-08-10 2013-04-25 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Neuer Wachstums/Differenzierungsfaktor der TGF-β-Familie
US5863738A (en) * 1994-04-29 1999-01-26 Creative Biomolecules, Inc. Methods of antagonizing OP-1 binding to a cell surface receptor utilizing ALK polypeptides
US5906827A (en) † 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
WO1998034655A1 (en) 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
DE69826854T2 (de) 1997-05-05 2006-02-02 Curis, Inc., Cambridge Therapien zur behandlung von akutem nierenversagen
CA2291514C (en) 1997-05-30 2011-07-12 Creative Biomolecules, Inc. Methods for evaluating tissue morphogenesis and activity
US6649631B1 (en) 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
JPH11313675A (ja) 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6838436B1 (en) 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6462019B1 (en) 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
AU772479B2 (en) 1998-10-06 2004-04-29 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
ES2225241T3 (es) 1999-10-15 2005-03-16 Genetics Institute, Llc Formulaciones de acido hialuronico para suministrar proteinas osteogenicas.
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
SI1448246T2 (sl) 2001-11-19 2015-12-31 Scil Technology Gmbh Postopek za proizvodnjo homogeno obložene naprave, ki ima osteoinduktivne in osteokonduktivne lastnosti
BR0309877A (pt) 2002-05-03 2005-04-26 Millenium Biologix Inc Peptìdeos estimuladores de tecido conectivo
AU2003253049A1 (en) 2002-09-10 2004-04-30 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
KR100794289B1 (ko) * 2002-11-08 2008-01-11 아이진 주식회사 Ｂｍｐ-7 폴리펩타이드를 포함하는 흉터 형성 억제제
SI1675608T1 (sl) 2003-09-12 2007-08-31 Wyeth Corp Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov
US7163920B2 (en) 2003-09-30 2007-01-16 Ethicon, Inc. Peptide with osteogenic activity
JP5201987B2 (ja) 2004-05-25 2013-06-05 ストライカー コーポレイション 軟骨欠損を処置するための、形態形成タンパク質の使用
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
ATE533781T1 (de) 2005-05-27 2011-12-15 Bbs Bioactive Bone Substitutes Oy Heparin-bindungsstelle enthaltendes knochenmorphogenetisches protein 6 und osteogene vorrichtungen und pharmazeutische produkte, die diese enthalten
US7771995B2 (en) * 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
US9011930B2 (en) 2006-05-01 2015-04-21 Zycal Bioceuticals Healthcare Company, Inc. Nutritional supplement and use thereof
CA2652549A1 (en) 2006-05-17 2007-12-13 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
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US8025872B2 (en) 2008-05-16 2011-09-27 Industry Foundation Of Chonnam National University Osteogenic synthetic peptides, pharmaceutical compositions comprising the same, and medium containing the same
EP2293808B1 (de) 2008-05-16 2012-08-15 Industry Foundation Of Chonnam National University Knochenformendes peptid 1 (bfp1) enthaltendes synthetisches peptid zur stimulierung der osteoblasten-differenzierung und das synthetische peptid enthaltende pharmazeutische zusammensetzung
WO2009154330A1 (en) * 2008-06-20 2009-12-23 Industry Foundation Of Chonnam National University An synthetic peptide containing bone forming peptide 2(bfp 2) for stimulating osteoblast differentiation, and pharmaceutical composition comprising the synthetic peptide
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DK3311666T3 (da) 2010-08-18 2021-06-28 Biosplice Therapeutics Inc Diketoner og hydroxyketoner som aktivatorer af catenin-signalvejen
US9216181B2 (en) 2011-06-08 2015-12-22 Southwest Research Institute BMP-2 upregulating compounds for healing bone tissue and screening methods for selecting such compounds
EP2968249B1 (de) 2013-02-22 2018-11-14 Samumed, LLC Gamma-diketone als wnt/beta-catenin-signalisierungspfadaktivatoren
KR102165385B1 (ko) 2014-08-20 2020-10-15 사뮤메드, 엘엘씨 피부 노화 및 주름의 치료 및 예방을 위한 감마-디케톤
CN109182430B (zh) * 2018-08-28 2022-10-21 南京赛尔健生物技术有限公司 一种流感疫苗免疫佐剂
CN109082453B (zh) * 2018-08-28 2022-10-21 南京赛尔健生物技术有限公司 一种多肽作为流感疫苗佐剂提高流感疫苗免疫效果的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
KR900700617A (ko) * 1988-04-08 1990-08-16 브루스 엠. 에이센 뼈 및 연골 유도 조성물
ATE134647T1 (de) * 1988-04-08 1996-03-15 Stryker Corp Osteogene vorrichtungen
JP2845346B2 (ja) * 1989-10-17 1999-01-13 ストライカー・コーポレーション 骨形成具

Also Published As

Publication number Publication date
CA2030518A1 (en) 1990-09-29
DK0429570T3 (da) 1998-04-27
EP0429570B1 (de) 1998-01-14
ES2113857T3 (es) 1998-05-16
ATE162223T1 (de) 1998-01-15
WO1990011366A1 (en) 1990-10-04
CA2030518C (en) 2000-03-21
KR100214740B1 (ko) 1999-08-02
DE69031939T2 (de) 1998-09-10
EP0429570A1 (de) 1991-06-05
KR920700291A (ko) 1992-02-19

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Owner name: GENETICS INSTITUTE, LLC, CAMBRIDGE, MASS., US