ATE533781T1 - Heparin-bindungsstelle enthaltendes knochenmorphogenetisches protein 6 und osteogene vorrichtungen und pharmazeutische produkte, die diese enthalten - Google Patents
Heparin-bindungsstelle enthaltendes knochenmorphogenetisches protein 6 und osteogene vorrichtungen und pharmazeutische produkte, die diese enthaltenInfo
- Publication number
- ATE533781T1 ATE533781T1 AT06743556T AT06743556T ATE533781T1 AT E533781 T1 ATE533781 T1 AT E533781T1 AT 06743556 T AT06743556 T AT 06743556T AT 06743556 T AT06743556 T AT 06743556T AT E533781 T1 ATE533781 T1 AT E533781T1
- Authority
- AT
- Austria
- Prior art keywords
- bone morphogenetic
- morphogenetic protein
- binding site
- heparin binding
- same
- Prior art date
Links
- 102000008154 Bone Morphogenetic Protein 6 Human genes 0.000 title abstract 2
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002897 heparin Drugs 0.000 title abstract 2
- 229920000669 heparin Polymers 0.000 title abstract 2
- 230000002188 osteogenic effect Effects 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract 3
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract 3
- 229940112869 bone morphogenetic protein Drugs 0.000 abstract 3
- 230000011164 ossification Effects 0.000 abstract 2
- 241000282941 Rangifer tarandus Species 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000022159 cartilage development Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20055257A FI121070B (fi) | 2005-05-27 | 2005-05-27 | Luun morfogeneettinen proteiini 6, sitä koodaava DNA, nukleotidivektori, rekombinantti isäntäsolu, farmaseuttinen koostumus ja osteogeeninen väline |
| FI20055258A FI119373B (fi) | 2005-05-27 | 2005-05-27 | Luun proteiineja |
| FI20055256A FI118736B (fi) | 2005-05-27 | 2005-05-27 | Luun morfogeneettinen proteiini |
| PCT/FI2006/050214 WO2006125868A1 (en) | 2005-05-27 | 2006-05-26 | Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533781T1 true ATE533781T1 (de) | 2011-12-15 |
Family
ID=37451667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06743556T ATE533781T1 (de) | 2005-05-27 | 2006-05-26 | Heparin-bindungsstelle enthaltendes knochenmorphogenetisches protein 6 und osteogene vorrichtungen und pharmazeutische produkte, die diese enthalten |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7910552B2 (de) |
| EP (1) | EP1885751B1 (de) |
| AT (1) | ATE533781T1 (de) |
| WO (1) | WO2006125868A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012023113A2 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Designer osteogenic proteins |
| WO2012029148A1 (ja) | 2010-09-01 | 2012-03-08 | 株式会社オステオファーマ | 組換えヒト骨形成タンパク質－２凍結乾燥製剤 |
| AU2015374114B2 (en) | 2014-12-29 | 2018-07-26 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| CN110092816B (zh) * | 2018-01-29 | 2023-08-01 | 上海市第一人民医院 | 预防和治疗纤维化的小分子多肽及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939388A (en) * | 1986-07-01 | 1999-08-17 | Rosen; Vicki A. | Methods of administering BMP-5 compositions |
| US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| US5459047A (en) | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
| US5106626A (en) | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| US5284756A (en) | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
| ES2113857T3 (es) | 1989-03-28 | 1998-05-16 | Genetics Inst | Composiciones osteoinductoras. |
| DE69133338T2 (de) | 1990-09-26 | 2004-04-15 | Genetics Institute, LLC, Cambridge | Bmp-5-derivate |
| US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| US6083690A (en) | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
| US20030032586A1 (en) | 1997-05-15 | 2003-02-13 | David C. Rueger | Compositions for morphogen-induced osteogenesis |
| US7601685B2 (en) | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| PT1131087E (pt) | 1998-11-13 | 2004-12-31 | Curis Inc | Metodos de alivio de sintomas de cancro |
| DE19906096A1 (de) * | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| WO2003042661A2 (en) | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20040253606A1 (en) | 2002-11-26 | 2004-12-16 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
| KR101013999B1 (ko) * | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
-
2006
- 2006-05-26 EP EP06743556A patent/EP1885751B1/de active Active
- 2006-05-26 US US11/921,069 patent/US7910552B2/en active Active
- 2006-05-26 AT AT06743556T patent/ATE533781T1/de active
- 2006-05-26 WO PCT/FI2006/050214 patent/WO2006125868A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1885751A1 (de) | 2008-02-13 |
| WO2006125868A1 (en) | 2006-11-30 |
| US7910552B2 (en) | 2011-03-22 |
| EP1885751A4 (de) | 2009-04-01 |
| US20100143433A1 (en) | 2010-06-10 |
| EP1885751B1 (de) | 2011-11-16 |
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