DK1140190T3 - Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer - Google Patents
Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorerInfo
- Publication number
- DK1140190T3 DK1140190T3 DK99967140T DK99967140T DK1140190T3 DK 1140190 T3 DK1140190 T3 DK 1140190T3 DK 99967140 T DK99967140 T DK 99967140T DK 99967140 T DK99967140 T DK 99967140T DK 1140190 T3 DK1140190 T3 DK 1140190T3
- Authority
- DK
- Denmark
- Prior art keywords
- bile acid
- combinations
- ileum
- transport inhibitors
- sequestrants
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11395598P | 1998-12-23 | 1998-12-23 | |
US14304399P | 1999-07-07 | 1999-07-07 | |
PCT/US1999/027949 WO2000038728A1 (en) | 1998-12-23 | 1999-12-17 | Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1140190T3 true DK1140190T3 (da) | 2002-12-23 |
Family
ID=26811681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99967140T DK1140190T3 (da) | 1998-12-23 | 1999-12-17 | Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer |
Country Status (24)
Country | Link |
---|---|
US (2) | US6562860B1 (no) |
EP (1) | EP1140190B1 (no) |
JP (1) | JP2002533414A (no) |
KR (1) | KR20010102965A (no) |
CN (1) | CN1338945A (no) |
AR (1) | AR022022A1 (no) |
AT (1) | ATE228012T1 (no) |
AU (1) | AU776953B2 (no) |
BR (1) | BR9916484A (no) |
CA (1) | CA2356156A1 (no) |
CZ (1) | CZ20012345A3 (no) |
DE (1) | DE69904079T2 (no) |
DK (1) | DK1140190T3 (no) |
EA (1) | EA004877B1 (no) |
ES (1) | ES2189529T3 (no) |
HK (1) | HK1044292A1 (no) |
HU (1) | HUP0104745A3 (no) |
IL (1) | IL143943A0 (no) |
MX (1) | MXPA01006470A (no) |
NO (1) | NO20013159L (no) |
NZ (1) | NZ512535A (no) |
PL (1) | PL348609A1 (no) |
PT (1) | PT1140190E (no) |
WO (1) | WO2000038728A1 (no) |
Families Citing this family (56)
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SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
AU2002224109A1 (en) * | 2000-11-28 | 2002-06-11 | Mitsubishi Pharma Corporation | Excretion accelerator for accumulative chlorine compound |
EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
EP1379259A1 (en) * | 2001-04-18 | 2004-01-14 | Genzyme Corporation | Methods of treating syndrome x with aliphatic polyamines |
GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
BRPI0212346B1 (pt) | 2001-09-08 | 2016-02-02 | Albireo Ab | Compostos derivados de benzotiadiazepina ou um sal farmaceuticamente aceitável do mesmo com efeito inibidor de transporte de ácido de bile ileal, processo para a preparação dos mesmos, uso destes, e, composição farmacêutica. |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
US20110294767A1 (en) | 2010-05-26 | 2011-12-01 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
RS55266B1 (sr) | 2010-11-08 | 2017-02-28 | Albireo Ab | Ibat inhibitori za lečenje bolesti jetre |
AU2011326872C1 (en) * | 2010-11-08 | 2015-02-19 | Albireo Ab | A pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder |
JP2012171911A (ja) | 2011-02-22 | 2012-09-10 | Kao Corp | Ppar活性化剤 |
ES2633766T3 (es) | 2011-10-28 | 2017-09-25 | Lumena Pharmaceuticals Llc | Inhibidores de reciclaje de ácido biliar para el tratamiento de enfermedades de hígado colestático pediátrico |
MX363161B (es) | 2011-10-28 | 2019-03-13 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica. |
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MX2015013196A (es) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett. |
JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
ES2874546T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
EP3664781A1 (en) | 2017-08-09 | 2020-06-17 | Albireo AB | Cholestyramine granules, oral cholestyramine formulations and use thereof |
WO2019032027A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2019234077A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2019245449A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Pharmaceutical formulation of odevixibat |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
FI3921028T3 (fi) | 2019-02-06 | 2023-01-31 | Bentsotiadiatsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina | |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
EP3921027B1 (en) | 2019-02-06 | 2023-07-19 | Albireo AB | Benzothiazepine compounds and their use as bile acid modulators |
AU2020221834A1 (en) | 2019-02-12 | 2021-09-02 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency |
CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
WO2021110886A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
AR120682A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar |
KR20220109450A (ko) | 2019-12-04 | 2022-08-04 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의 이의 용도 |
EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202134223A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
TW202134218A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其作為膽酸調節劑之用途 |
AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症(pfic)を処置するためのオデビキシバット |
AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
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-
1999
- 1999-12-17 CA CA002356156A patent/CA2356156A1/en not_active Abandoned
- 1999-12-17 WO PCT/US1999/027949 patent/WO2000038728A1/en not_active Application Discontinuation
- 1999-12-17 EA EA200100702A patent/EA004877B1/ru not_active IP Right Cessation
- 1999-12-17 AT AT99967140T patent/ATE228012T1/de not_active IP Right Cessation
- 1999-12-17 NZ NZ512535A patent/NZ512535A/en unknown
- 1999-12-17 DK DK99967140T patent/DK1140190T3/da active
- 1999-12-17 CN CN99816267A patent/CN1338945A/zh active Pending
- 1999-12-17 ES ES99967140T patent/ES2189529T3/es not_active Expired - Lifetime
- 1999-12-17 AU AU23480/00A patent/AU776953B2/en not_active Ceased
- 1999-12-17 KR KR1020017008090A patent/KR20010102965A/ko not_active Application Discontinuation
- 1999-12-17 JP JP2000590679A patent/JP2002533414A/ja active Pending
- 1999-12-17 EP EP99967140A patent/EP1140190B1/en not_active Revoked
- 1999-12-17 PT PT99967140T patent/PT1140190E/pt unknown
- 1999-12-17 PL PL99348609A patent/PL348609A1/xx not_active Application Discontinuation
- 1999-12-17 HU HU0104745A patent/HUP0104745A3/hu unknown
- 1999-12-17 BR BR9916484-1A patent/BR9916484A/pt not_active IP Right Cessation
- 1999-12-17 CZ CZ20012345A patent/CZ20012345A3/cs unknown
- 1999-12-17 US US09/466,592 patent/US6562860B1/en not_active Expired - Fee Related
- 1999-12-17 IL IL14394399A patent/IL143943A0/xx unknown
- 1999-12-17 MX MXPA01006470A patent/MXPA01006470A/es unknown
- 1999-12-17 DE DE69904079T patent/DE69904079T2/de not_active Expired - Fee Related
- 1999-12-23 AR ARP990106753A patent/AR022022A1/es not_active Application Discontinuation
-
2001
- 2001-06-22 NO NO20013159A patent/NO20013159L/no not_active Application Discontinuation
-
2002
- 2002-08-15 HK HK02105982.7A patent/HK1044292A1/zh unknown
-
2003
- 2003-02-26 US US10/373,180 patent/US20040029845A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6562860B1 (en) | 2003-05-13 |
BR9916484A (pt) | 2002-01-22 |
CZ20012345A3 (cs) | 2001-12-12 |
PT1140190E (pt) | 2003-02-28 |
DE69904079T2 (de) | 2003-07-17 |
HUP0104745A2 (hu) | 2002-04-29 |
ES2189529T3 (es) | 2003-07-01 |
DE69904079D1 (de) | 2003-01-02 |
US20040029845A1 (en) | 2004-02-12 |
MXPA01006470A (es) | 2003-06-06 |
HK1044292A1 (zh) | 2002-10-18 |
ATE228012T1 (de) | 2002-12-15 |
AR022022A1 (es) | 2002-09-04 |
HUP0104745A3 (en) | 2003-01-28 |
NZ512535A (en) | 2003-12-19 |
CA2356156A1 (en) | 2000-07-06 |
NO20013159D0 (no) | 2001-06-22 |
NO20013159L (no) | 2001-08-22 |
IL143943A0 (en) | 2002-04-21 |
JP2002533414A (ja) | 2002-10-08 |
CN1338945A (zh) | 2002-03-06 |
EA004877B1 (ru) | 2004-08-26 |
EP1140190B1 (en) | 2002-11-20 |
WO2000038728A1 (en) | 2000-07-06 |
EP1140190A1 (en) | 2001-10-10 |
AU776953B2 (en) | 2004-09-30 |
KR20010102965A (ko) | 2001-11-17 |
PL348609A1 (en) | 2002-06-03 |
AU2348000A (en) | 2000-07-31 |
EA200100702A1 (ru) | 2001-12-24 |
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