DK1129091T3 - Antagonister for CRF-receptorer og fremgangsmåder med relation dertil - Google Patents

Antagonister for CRF-receptorer og fremgangsmåder med relation dertil

Info

Publication number
DK1129091T3
DK1129091T3 DK99960363T DK99960363T DK1129091T3 DK 1129091 T3 DK1129091 T3 DK 1129091T3 DK 99960363 T DK99960363 T DK 99960363T DK 99960363 T DK99960363 T DK 99960363T DK 1129091 T3 DK1129091 T3 DK 1129091T3
Authority
DK
Denmark
Prior art keywords
antagonists
crf
associated methods
crf receptors
crf receptor
Prior art date
Application number
DK99960363T
Other languages
Danish (da)
English (en)
Inventor
Mustapha Haddach
Jodie Nelson
Brian P Dyck
Zhiqiang Guo
Charles Q Huang
James R Mccarthy
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of DK1129091T3 publication Critical patent/DK1129091T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
DK99960363T 1998-11-12 1999-11-12 Antagonister for CRF-receptorer og fremgangsmåder med relation dertil DK1129091T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19107398A 1998-11-12 1998-11-12
US37083799A 1999-08-09 1999-08-09
US40136499A 1999-09-21 1999-09-21
PCT/US1999/027054 WO2000027846A2 (en) 1998-11-12 1999-11-12 Crf receptor antagonists and methods relating thereto

Publications (1)

Publication Number Publication Date
DK1129091T3 true DK1129091T3 (da) 2002-11-04

Family

ID=27392849

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99960363T DK1129091T3 (da) 1998-11-12 1999-11-12 Antagonister for CRF-receptorer og fremgangsmåder med relation dertil

Country Status (17)

Country Link
US (1) US6514982B1 (enExample)
EP (1) EP1129091B1 (enExample)
JP (1) JP2002529465A (enExample)
KR (1) KR20010080990A (enExample)
CN (1) CN1217945C (enExample)
AT (1) ATE225349T1 (enExample)
AU (1) AU755552B2 (enExample)
CA (1) CA2350642A1 (enExample)
DE (1) DE69903333T2 (enExample)
DK (1) DK1129091T3 (enExample)
ES (1) ES2180338T3 (enExample)
HK (1) HK1038926B (enExample)
IL (1) IL142893A0 (enExample)
NO (1) NO20012194L (enExample)
NZ (1) NZ510955A (enExample)
PT (1) PT1129091E (enExample)
WO (1) WO2000027846A2 (enExample)

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US6531475B1 (en) * 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
IL142893A0 (en) * 1998-11-12 2002-04-21 Neurocrine Biosciences Inc Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same
AU2001232271A1 (en) * 2000-02-14 2001-08-20 Japan Tobacco Inc. Preventives/remedies for postoperative stress
AU2001263288A1 (en) 2000-05-18 2001-11-26 Neurocrine Biosciences, Inc. Crf receptor antagonists
MXPA03003714A (es) * 2000-11-03 2004-05-04 Neurocrine Biosciences Inc Antagonistas del receptor crf y metodos relacionados con los mismos.
RU2291869C2 (ru) 2000-12-28 2007-01-20 Оно Фармасьютикал Ко., Лтд. Три-гетероциклические соединения и фармацевтическое средство, содержащее их в качестве активного ингредиента
WO2002064592A1 (en) * 2000-12-28 2002-08-22 Neurocrine Biosciences, Inc. Tricyclic crf receptor antagonists
CZ20032945A3 (cs) * 2001-04-30 2004-02-18 Glaxo Group Limited Antagonisty receptoru CRF
CN1529705A (zh) * 2001-05-21 2004-09-15 Ŧ�޿���������ѧ��˾ 作为crf受体拮抗剂的三-与四-氮杂苊衍生物
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
US7273871B2 (en) 2001-07-17 2007-09-25 Sb Pharmco Puerto Rico Inc. Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
ES2349393T3 (es) 2003-06-25 2010-12-30 Ono Pharmaceutical Co., Ltd. Sal del ácido metanosulfónico del compuesto de pirazolopirimidina, cristal del mismo y proceso para la producción del mismo.
US20060024661A1 (en) * 2003-07-30 2006-02-02 The Regents Of The University Of California Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
JP2007501822A (ja) * 2003-08-12 2007-02-01 エフ．ホフマン−ラ　ロシュ　アーゲー コルチコトロピン放出性因子（ｃｒｆ）アンタゴニストとしてのスピロ置換テトラヒドロキナゾリン
WO2005063749A1 (en) * 2003-12-22 2005-07-14 Sb Pharmco Puerto Rico Inc Crf receptor antagonists and methods relating thereto
PT1718608E (pt) 2004-02-20 2013-08-01 Boehringer Ingelheim Int Inibidores da polimerase viral
WO2005087775A1 (ja) * 2004-03-15 2005-09-22 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
US7869958B2 (en) * 2004-08-09 2011-01-11 Research Development Foundation Structure-based modulators of B1 G-protein coupled receptors
AU2008211729A1 (en) 2007-02-01 2008-08-07 Astrazeneca Ab 5,6,7,8-tetrahydropteridine derivatives as HSP90 inhibitors
CA2756815A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Peri-fused pyrazolo-pyrimidine compounds
PL2440558T3 (pl) 2009-06-08 2015-10-30 Takeda Pharmaceuticals Co Związki dihydropirolonaftyrydynony jako inhibitory JAK
PH12012501337A1 (en) * 2009-12-30 2012-12-17 Arqule Inc Substituted pyrrolo-aminopyrimidine compounds
CN113416191A (zh) * 2021-04-27 2021-09-21 西安交通大学 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法

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US4605642A (en) 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5013737A (en) * 1988-02-22 1991-05-07 American Cyanamid Company 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US4904658A (en) 1988-04-15 1990-02-27 American Cyanamid Company Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
US5063245A (en) 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
FR2692893B1 (fr) 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
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DK0674624T3 (da) 1992-12-17 1999-09-13 Pfizer Pyrazoler med CRF-antagonistisk aktivitet
KR19990067704A (ko) * 1992-12-17 1999-08-25 디. 제이. 우드, 스피겔 알렌 제이 부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물
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DE69603240T2 (de) 1995-05-12 2000-01-05 Neurogen Corp., Branford Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
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WO1997035846A1 (en) 1996-03-26 1997-10-02 Dupont Pharmaceuticals Company Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives
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US6326368B1 (en) 1996-03-27 2001-12-04 Dupont Pharmaceuticals Company Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof
ZA973884B (en) 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
HU228962B1 (en) 1996-07-24 2013-07-29 Bristol Myers Squibb Pharma Co Azolo triazines, pharmaceutical compositions containing them and use of the compounds
WO1998005661A1 (en) 1996-08-06 1998-02-12 Pfizer Inc. Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
TW477787B (en) 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
ES2273369T3 (es) 1996-08-28 2007-05-01 Pfizer Inc. Derivados 6,5 heterobiciclicos sustituidos.
CA2265672C (en) 1996-09-16 2008-12-02 Du Pont Pharmaceuticals Company Pyrazinones and triazinones and their derivatives thereof
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US5760225A (en) 1996-11-15 1998-06-02 Neurogen Corporation Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands
US5723608A (en) 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
IL142893A0 (en) * 1998-11-12 2002-04-21 Neurocrine Biosciences Inc Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
AU1725800A (en) 2000-05-29
CN1328559A (zh) 2001-12-26
NZ510955A (en) 2003-01-31
CA2350642A1 (en) 2000-05-18
KR20010080990A (ko) 2001-08-25
EP1129091B1 (en) 2002-10-02
US6514982B1 (en) 2003-02-04
ATE225349T1 (de) 2002-10-15
DE69903333D1 (de) 2002-11-07
NO20012194D0 (no) 2001-05-03
ES2180338T3 (es) 2003-02-01
WO2000027846A2 (en) 2000-05-18
PT1129091E (pt) 2003-02-28
JP2002529465A (ja) 2002-09-10
CN1217945C (zh) 2005-09-07
EP1129091A2 (en) 2001-09-05
WO2000027846A3 (en) 2000-11-16
HK1038926A1 (en) 2002-05-10
IL142893A0 (en) 2002-04-21
HK1038926B (en) 2003-07-18
AU755552B2 (en) 2002-12-12
DE69903333T2 (de) 2003-08-07
NO20012194L (no) 2001-05-03

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