HK1038926B - Crf receptor antagonists and methods relating thereto - Google Patents

Crf receptor antagonists and methods relating thereto Download PDF

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Publication number
HK1038926B
HK1038926B HK02100690.1A HK02100690A HK1038926B HK 1038926 B HK1038926 B HK 1038926B HK 02100690 A HK02100690 A HK 02100690A HK 1038926 B HK1038926 B HK 1038926B
Authority
HK
Hong Kong
Prior art keywords
compound
substituted
alkyl
methyl
phenyl
Prior art date
Application number
HK02100690.1A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1038926A1 (en
Inventor
Haddach Mustapha
Nelson Jodie
P. Dyck Brian
Guo Zhiqiang
Q. Huang Charles
R. Mccarthy James
Original Assignee
Neurocrine Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences, Inc. filed Critical Neurocrine Biosciences, Inc.
Publication of HK1038926A1 publication Critical patent/HK1038926A1/en
Publication of HK1038926B publication Critical patent/HK1038926B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
HK02100690.1A 1998-11-12 1999-11-12 Crf receptor antagonists and methods relating thereto HK1038926B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19107398A 1998-11-12 1998-11-12
US191073 1998-11-12
US37083799A 1999-08-09 1999-08-09
US370837 1999-08-09
US40136499A 1999-09-21 1999-09-21
US401364 1999-09-21
PCT/US1999/027054 WO2000027846A2 (en) 1998-11-12 1999-11-12 Crf receptor antagonists and methods relating thereto

Publications (2)

Publication Number Publication Date
HK1038926A1 HK1038926A1 (en) 2002-05-10
HK1038926B true HK1038926B (en) 2003-07-18

Family

ID=27392849

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02100690.1A HK1038926B (en) 1998-11-12 1999-11-12 Crf receptor antagonists and methods relating thereto

Country Status (17)

Country Link
US (1) US6514982B1 (enExample)
EP (1) EP1129091B1 (enExample)
JP (1) JP2002529465A (enExample)
KR (1) KR20010080990A (enExample)
CN (1) CN1217945C (enExample)
AT (1) ATE225349T1 (enExample)
AU (1) AU755552B2 (enExample)
CA (1) CA2350642A1 (enExample)
DE (1) DE69903333T2 (enExample)
DK (1) DK1129091T3 (enExample)
ES (1) ES2180338T3 (enExample)
HK (1) HK1038926B (enExample)
IL (1) IL142893A0 (enExample)
NO (1) NO20012194L (enExample)
NZ (1) NZ510955A (enExample)
PT (1) PT1129091E (enExample)
WO (1) WO2000027846A2 (enExample)

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ATE225349T1 (de) * 1998-11-12 2002-10-15 Neurocrine Biosciences Inc Crf rezeptor-antagonisten und darauf bezogene methoden
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
KR20030016222A (ko) * 2000-02-14 2003-02-26 니뽄 다바코 산교 가부시키가이샤 수술후 스트레스 예방ㆍ치료제
EP1287002A1 (en) * 2000-05-18 2003-03-05 Neurocrine Biosciences, Inc. Crf receptor antagonists
MXPA03003714A (es) 2000-11-03 2004-05-04 Neurocrine Biosciences Inc Antagonistas del receptor crf y metodos relacionados con los mismos.
US6583143B2 (en) 2000-12-28 2003-06-24 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
KR100843281B1 (ko) 2000-12-28 2008-07-09 오노 야꾸힝 고교 가부시키가이샤 삼환식 복소환 유도체 화합물 및 그 화합물을 유효성분으로 하는 의약
DE60209885T2 (de) 2001-04-30 2006-08-10 Glaxo Group Ltd., Greenford Crf-rezeptorantagonisten
MXPA03010635A (es) * 2001-05-21 2004-12-06 Sb Pharmco Inc Derivados de tri- y tetraazaacenaftileno como antagonistas del receptor de crf.
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
US7273871B2 (en) 2001-07-17 2007-09-25 Sb Pharmco Puerto Rico Inc. Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
CA2529561C (en) 2003-06-25 2012-05-29 Ono Pharmaceutical Co., Ltd. Methanesulfonic acid salt of pyrazolopyrimidine compound, crystal thereof, and process for producing the same
US20060024661A1 (en) * 2003-07-30 2006-02-02 The Regents Of The University Of California Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
EP1656145A1 (en) * 2003-08-12 2006-05-17 F. Hoffmann-La Roche Ag Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists
EP1697362B1 (en) * 2003-12-22 2008-03-05 SB Pharmco Puerto Rico Inc. Crf receptor antagonists and methods relating thereto
UY28758A1 (es) 2004-02-20 2005-09-30 Boehringer Ingelheim Int Inhibidores de polimerasa viral
WO2005087775A1 (ja) * 2004-03-15 2005-09-22 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
US7869958B2 (en) * 2004-08-09 2011-01-11 Research Development Foundation Structure-based modulators of B1 G-protein coupled receptors
WO2008093075A2 (en) 2007-02-01 2008-08-07 Astrazeneca Ab 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors
EP2414359A1 (en) 2009-03-31 2012-02-08 ArQule, Inc. Peri-fused pyrazolo-pyrimidine compounds
HUE026518T2 (en) 2009-06-08 2016-06-28 Takeda Pharmaceuticals Co Dihydro-pyrrolo-naphthyridinone compounds as JAK inhibitors
PH12012501337A1 (en) * 2009-12-30 2012-12-17 Arqule Inc Substituted pyrrolo-aminopyrimidine compounds
CN113416191A (zh) * 2021-04-27 2021-09-21 西安交通大学 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法

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US4904658A (en) 1988-04-15 1990-02-27 American Cyanamid Company Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
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TW477787B (en) 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
JP3621706B2 (ja) * 1996-08-28 2005-02-16 ファイザー・インク 置換された６，５―ヘテロ―二環式誘導体
JP2001502300A (ja) 1996-09-16 2001-02-20 デュポン ファーマシューティカルズ カンパニー ピラジノン類およびトリアジノン類およびその誘導体類
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ATE225349T1 (de) * 1998-11-12 2002-10-15 Neurocrine Biosciences Inc Crf rezeptor-antagonisten und darauf bezogene methoden

Also Published As

Publication number Publication date
EP1129091B1 (en) 2002-10-02
HK1038926A1 (en) 2002-05-10
US6514982B1 (en) 2003-02-04
AU1725800A (en) 2000-05-29
WO2000027846A3 (en) 2000-11-16
ES2180338T3 (es) 2003-02-01
NO20012194D0 (no) 2001-05-03
WO2000027846A2 (en) 2000-05-18
PT1129091E (pt) 2003-02-28
IL142893A0 (en) 2002-04-21
NZ510955A (en) 2003-01-31
DE69903333D1 (de) 2002-11-07
CN1217945C (zh) 2005-09-07
JP2002529465A (ja) 2002-09-10
DE69903333T2 (de) 2003-08-07
CA2350642A1 (en) 2000-05-18
ATE225349T1 (de) 2002-10-15
AU755552B2 (en) 2002-12-12
KR20010080990A (ko) 2001-08-25
EP1129091A2 (en) 2001-09-05
DK1129091T3 (da) 2002-11-04
NO20012194L (no) 2001-05-03
CN1328559A (zh) 2001-12-26

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20061112