DK110188D0 - High molecular weight prodrug derivatives of antiinflammatory drugs - Google Patents

High molecular weight prodrug derivatives of antiinflammatory drugs

Info

Publication number
DK110188D0
DK110188D0 DK110188A DK110188A DK110188D0 DK 110188 D0 DK110188 D0 DK 110188D0 DK 110188 A DK110188 A DK 110188A DK 110188 A DK110188 A DK 110188A DK 110188 D0 DK110188 D0 DK 110188D0
Authority
DK
Denmark
Prior art keywords
absent
residue
formula
group
drug
Prior art date
Application number
DK110188A
Other languages
Danish (da)
English (en)
Inventor
Claus Selch Larsen
Marianne Johansen
Elin Harboe
Peter Kurtzhals
Henning Peter Olesen
Original Assignee
Claus Selch Larsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Claus Selch Larsen filed Critical Claus Selch Larsen
Priority to DK110188A priority Critical patent/DK110188D0/da
Publication of DK110188D0 publication Critical patent/DK110188D0/da
Priority to AT89302051T priority patent/ATE83383T1/de
Priority to EP19890302051 priority patent/EP0331471B1/en
Priority to PCT/DK1989/000047 priority patent/WO1989008119A1/en
Priority to DE8989302051T priority patent/DE68903852T2/de
Priority to JP1503409A priority patent/JPH04505334A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DK110188A 1988-03-02 1988-03-02 High molecular weight prodrug derivatives of antiinflammatory drugs DK110188D0 (da)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DK110188A DK110188D0 (da) 1988-03-02 1988-03-02 High molecular weight prodrug derivatives of antiinflammatory drugs
AT89302051T ATE83383T1 (de) 1988-03-02 1989-03-01 Hochmolekulare prodrogenderivate von entzuendungshemmenden arzneimitteln.
EP19890302051 EP0331471B1 (en) 1988-03-02 1989-03-01 High molecular weight prodrug derivatives of antiinflammatory drugs
PCT/DK1989/000047 WO1989008119A1 (en) 1988-03-02 1989-03-01 High molecular weight prodrug derivatives of anti-inflammatory drugs
DE8989302051T DE68903852T2 (de) 1988-03-02 1989-03-01 Hochmolekulare prodrogenderivate von entzuendungshemmenden arzneimitteln.
JP1503409A JPH04505334A (ja) 1988-03-02 1989-03-01 抗炎症薬の高分子量プロドラッグ誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK110188A DK110188D0 (da) 1988-03-02 1988-03-02 High molecular weight prodrug derivatives of antiinflammatory drugs

Publications (1)

Publication Number Publication Date
DK110188D0 true DK110188D0 (da) 1988-03-02

Family

ID=8101004

Family Applications (1)

Application Number Title Priority Date Filing Date
DK110188A DK110188D0 (da) 1988-03-02 1988-03-02 High molecular weight prodrug derivatives of antiinflammatory drugs

Country Status (6)

Country Link
EP (1) EP0331471B1 (ja)
JP (1) JPH04505334A (ja)
AT (1) ATE83383T1 (ja)
DE (1) DE68903852T2 (ja)
DK (1) DK110188D0 (ja)
WO (1) WO1989008119A1 (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
ATE185267T1 (de) * 1990-05-04 1999-10-15 Perio Prod Ltd System zur arzneistoffabgabe im colon
AU659107B2 (en) * 1990-11-06 1995-05-11 Fgn, Inc. Method for treating colonic polyps by the use of esters and amides of substituted fused ring phenyl acetic acids
AU659106B2 (en) * 1990-11-06 1995-05-11 Fgn, Inc. Method for treating colonic polyps by the use of esters and amides of substituted phenyl and pyridyl amino carboxylates
AU650914B2 (en) * 1990-11-06 1994-07-07 Fgn, Inc. Esters and amides of substituted phenyl acetic acids
AU658373B2 (en) * 1990-11-06 1995-04-13 Fgn, Inc. Esters and amides of substituted pyrrole acetic acids
AU650689B2 (en) * 1990-11-06 1994-06-30 Fgn, Inc. Esters and amides of substituted indenyl acetic acids
EP0540751A4 (en) * 1991-05-20 1994-10-26 Eisai Co Ltd Steroid compound combined with polysaccharide
SE9103110D0 (sv) * 1991-10-24 1991-10-24 Kabi Pharmacia Ab New drug formulation
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
ATE293451T1 (de) * 1996-12-13 2005-05-15 Lescarden Inc Behandlung der osteoarthritis durch verabreichung von poly-n-acetyl-d-glucosamin
US5902800A (en) * 1998-03-27 1999-05-11 Glenpharma Dextran formulations and method for treatment of inflammatory joint disorders
FR2809735B1 (fr) * 2000-06-02 2003-08-01 Biodex Composition pharmaceutique contenant au moins un polymere associe ou conjugue a au moins un sel d'un acide phenylalkycarboxylique, polymeres conjugues et leurs applications
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
US6897348B2 (en) 2001-12-19 2005-05-24 Kimberly Clark Worldwide, Inc Bandage, methods of producing and using same
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
KR101174510B1 (ko) 2002-09-11 2012-08-16 프레제니우스 카비 도이치란트 게엠베하 하이드록시알킬전분화 폴리펩티드, 특히 하이드록시알킬전분화 에리트로포이에틴
DE60323756D1 (de) 2002-10-08 2008-11-06 Fresenius Kabi De Gmbh Pharmazeutisch aktive oligosaccharid-conjugate
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
AU2005203988B2 (en) * 2004-01-07 2010-11-11 Seikagaku Corporation Hyaluronic acid derivative and drug containing the same
EP2336192A1 (en) 2004-03-11 2011-06-22 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
ES2641570T3 (es) * 2004-03-31 2017-11-10 University Of Utah Research Foundation Sistemas de suministro macromoleculares para imagenología no invasiva, evaluación y tratamiento de artritis y otras enfermedades inflamatorias
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
US20210023017A1 (en) * 2018-03-16 2021-01-28 University Of Massachusetts Yeast cell wall particle encapsulation of biodegradable pro-payloads
JP7404228B2 (ja) * 2018-03-22 2023-12-25 持田製薬株式会社 非ステロイド性抗炎症性化合物結合アルギン酸誘導体
WO2021060351A1 (ja) * 2019-09-25 2021-04-01 持田製薬株式会社 ＮＳＡＩＤｓ結合アルギン酸誘導体
WO2021060395A1 (ja) * 2019-09-25 2021-04-01 持田製薬株式会社 徐放性医薬組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003990A (en) * 1972-06-29 1977-01-18 Societe Anonyme Dite: L'oreal Anti-inflammatory polymers, pharmaceutical compositions containing the same and process for producing said polymers
SE431937B (sv) * 1979-01-29 1984-03-12 Perstorp Ab Salicylazosulfapyridinhaltigt medicinskt preparat
EP0019403B1 (en) * 1979-05-10 1985-07-31 American Hospital Supply Corporation Hydroxyalkyl-starch drug carrier
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
IT1203814B (it) * 1986-06-30 1989-02-23 Fidia Farmaceutici Esteri dell'acido alginico

Also Published As

Publication number Publication date
DE68903852T2 (de) 1993-06-17
WO1989008119A1 (en) 1989-09-08
JPH04505334A (ja) 1992-09-17
DE68903852D1 (de) 1993-01-28
EP0331471B1 (en) 1992-12-16
ATE83383T1 (de) 1993-01-15
EP0331471A1 (en) 1989-09-06

Similar Documents

Publication Publication Date Title
DK110188D0 (da) High molecular weight prodrug derivatives of antiinflammatory drugs
ES2173096T3 (es) Composicion farmaceutica peletizada.
AU728826B2 (en) Compositions for treating and preventing arterial thrombosis and use of a factor Xa inhibitor on its own and/or combined with a platelet antiaggregating agent
US3510561A (en) Sulfone-enhanced heparin absorption through mucous membranes
RO108220B1 (ro) Preparate farmaceutice,pentru combaterea carceilor musculari si procedeu de obtinere a acestora
KR890009376A (ko) 분무 건조된 이부프로펜
ATE4903T1 (de) 1-, 6- und 2-substituierte 1-carba-2-penem-3carbons[ure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
CA2111560A1 (en) Stable pharmaceutical composition of fumagillol derivatives
ATE172111T1 (de) Arzneizusammensetzungen enthaltend nanokapseln
KR920012113A (ko) 펩타이드 유도체의 사용방법
KR920702216A (ko) 아세틸 d-카르니틴의 녹내장 치료에의 용도
TW200519129A (en) Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition, and pharmaceutical or bioactive composition containing the micelle composition
JPH08505161A (ja) 自己架橋ゲランガム
CA2079205A1 (en) Use of Hyaluronic Acid and Forms to Prevent Arterial Restenosis
ATE151770T1 (de) Cephalosporinverbindungen und deren herstellung
JPH07157431A (ja) 安定なプロスタグランジンｅ製剤
FI892685A0 (fi) Menetelmä uusien, sytostaattisesti vaikuttavien antrasykliinijohdannaisten valmistamiseksi
KR950010896A (ko) 근시의 예방 및 치료용 조성물
KR870006081A (ko) 신규 16,17-아세탈치환 프레그난 21-오익 에시드유도체 및 그의 제조방법
WO1991012803A1 (en) Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents
US3594482A (en) Method of treating a pathological fibrinolytic state in mammals
JPS57209272A (en) Indirubin derivative and antitumor agent containing the same
JPH03251526A (ja) 糖尿病依存型自己免疫疾患治療、予防用薬剤
KR940002268A (ko) 21-클로로-프레그난 유도체
KR910000650A (ko) 사이클릭 안트라닐산 아세트산 유도체 및 이의 제조방법

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment