JPS57209272A - Indirubin derivative and antitumor agent containing the same - Google Patents

Indirubin derivative and antitumor agent containing the same

Info

Publication number
JPS57209272A
JPS57209272A JP9507181A JP9507181A JPS57209272A JP S57209272 A JPS57209272 A JP S57209272A JP 9507181 A JP9507181 A JP 9507181A JP 9507181 A JP9507181 A JP 9507181A JP S57209272 A JPS57209272 A JP S57209272A
Authority
JP
Japan
Prior art keywords
formula
indirubin
antitumor agent
same
agent containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9507181A
Other languages
Japanese (ja)
Other versions
JPS609023B2 (en
Inventor
Tendou Tsutsumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISUKURA SANGYO KK
Iskra Industry Co Ltd
Original Assignee
ISUKURA SANGYO KK
Iskra Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISUKURA SANGYO KK, Iskra Industry Co Ltd filed Critical ISUKURA SANGYO KK
Priority to JP9507181A priority Critical patent/JPS609023B2/en
Publication of JPS57209272A publication Critical patent/JPS57209272A/en
Publication of JPS609023B2 publication Critical patent/JPS609023B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:The indirubin derivative of formulaI(three Rs are the same group of formula II or formula III).
EXAMPLE: The compound of formula IV.
USE: Low toxic antitumor agent giving weak stimulation to the gastroenteric tracts compared with indirubin, and having improved solubility and absorbability to the living body.
PROCESS: The compound of formulaIcan be prepared by dissolving indirubin of formula V in anhydrous pyridine, hydrogenating in the presence of a platinum oxide catalyst, and acylating with 4-dimethylaminopyridine and acetic anhydride.
COPYRIGHT: (C)1982,JPO&Japio
JP9507181A 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them Expired JPS609023B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9507181A JPS609023B2 (en) 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9507181A JPS609023B2 (en) 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them

Publications (2)

Publication Number Publication Date
JPS57209272A true JPS57209272A (en) 1982-12-22
JPS609023B2 JPS609023B2 (en) 1985-03-07

Family

ID=14127751

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9507181A Expired JPS609023B2 (en) 1981-06-19 1981-06-19 Indirubin derivatives and antitumor agents containing them

Country Status (1)

Country Link
JP (1) JPS609023B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061555A1 (en) * 1999-04-12 2000-10-19 Gerhard Eisenbrand Indigoid bisindole derivatives
WO2000061124A3 (en) * 1999-04-12 2002-05-02 Heinz Herbert Fiebig Use off cell membrane penetrating indigoid bisindole derivatives
WO2004039797A1 (en) * 2002-10-29 2004-05-13 Jingcai Cheng A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061555A1 (en) * 1999-04-12 2000-10-19 Gerhard Eisenbrand Indigoid bisindole derivatives
WO2000061124A3 (en) * 1999-04-12 2002-05-02 Heinz Herbert Fiebig Use off cell membrane penetrating indigoid bisindole derivatives
JP2002541189A (en) * 1999-04-12 2002-12-03 ゲルハルト アイゼンブランド Use of cell membrane permeable indigoid bisindole derivatives
US6987092B1 (en) 1999-04-12 2006-01-17 Faustus Forschungs Cie. Translational Cancer Research Gmbh Indigoid bisindole derivatives
WO2004039797A1 (en) * 2002-10-29 2004-05-13 Jingcai Cheng A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer

Also Published As

Publication number Publication date
JPS609023B2 (en) 1985-03-07

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