JPS57209272A - Indirubin derivative and antitumor agent containing the same - Google Patents
Indirubin derivative and antitumor agent containing the sameInfo
- Publication number
- JPS57209272A JPS57209272A JP9507181A JP9507181A JPS57209272A JP S57209272 A JPS57209272 A JP S57209272A JP 9507181 A JP9507181 A JP 9507181A JP 9507181 A JP9507181 A JP 9507181A JP S57209272 A JPS57209272 A JP S57209272A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- indirubin
- antitumor agent
- same
- agent containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:The indirubin derivative of formulaI(three Rs are the same group of formula II or formula III).
EXAMPLE: The compound of formula IV.
USE: Low toxic antitumor agent giving weak stimulation to the gastroenteric tracts compared with indirubin, and having improved solubility and absorbability to the living body.
PROCESS: The compound of formulaIcan be prepared by dissolving indirubin of formula V in anhydrous pyridine, hydrogenating in the presence of a platinum oxide catalyst, and acylating with 4-dimethylaminopyridine and acetic anhydride.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9507181A JPS609023B2 (en) | 1981-06-19 | 1981-06-19 | Indirubin derivatives and antitumor agents containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9507181A JPS609023B2 (en) | 1981-06-19 | 1981-06-19 | Indirubin derivatives and antitumor agents containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57209272A true JPS57209272A (en) | 1982-12-22 |
JPS609023B2 JPS609023B2 (en) | 1985-03-07 |
Family
ID=14127751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9507181A Expired JPS609023B2 (en) | 1981-06-19 | 1981-06-19 | Indirubin derivatives and antitumor agents containing them |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS609023B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061555A1 (en) * | 1999-04-12 | 2000-10-19 | Gerhard Eisenbrand | Indigoid bisindole derivatives |
WO2000061124A3 (en) * | 1999-04-12 | 2002-05-02 | Heinz Herbert Fiebig | Use off cell membrane penetrating indigoid bisindole derivatives |
WO2004039797A1 (en) * | 2002-10-29 | 2004-05-13 | Jingcai Cheng | A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer |
-
1981
- 1981-06-19 JP JP9507181A patent/JPS609023B2/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061555A1 (en) * | 1999-04-12 | 2000-10-19 | Gerhard Eisenbrand | Indigoid bisindole derivatives |
WO2000061124A3 (en) * | 1999-04-12 | 2002-05-02 | Heinz Herbert Fiebig | Use off cell membrane penetrating indigoid bisindole derivatives |
JP2002541189A (en) * | 1999-04-12 | 2002-12-03 | ゲルハルト アイゼンブランド | Use of cell membrane permeable indigoid bisindole derivatives |
US6987092B1 (en) | 1999-04-12 | 2006-01-17 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Indigoid bisindole derivatives |
WO2004039797A1 (en) * | 2002-10-29 | 2004-05-13 | Jingcai Cheng | A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer |
Also Published As
Publication number | Publication date |
---|---|
JPS609023B2 (en) | 1985-03-07 |
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