KR890009376A - 분무 건조된 이부프로펜 - Google Patents

분무 건조된 이부프로펜 Download PDF

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Publication number
KR890009376A
KR890009376A KR1019880016246A KR880016246A KR890009376A KR 890009376 A KR890009376 A KR 890009376A KR 1019880016246 A KR1019880016246 A KR 1019880016246A KR 880016246 A KR880016246 A KR 880016246A KR 890009376 A KR890009376 A KR 890009376A
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KR
South Korea
Prior art keywords
ibuprofen
powder
spray
weight
plasticizer
Prior art date
Application number
KR1019880016246A
Other languages
English (en)
Other versions
KR960013283B1 (ko
Inventor
티엔 리차드 호 잉
조오지 블랭크 로버트
Original Assignee
원본미기재
아메리칸 홈 프로덕츠 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 원본미기재, 아메리칸 홈 프로덕츠 코포레이션 filed Critical 원본미기재
Publication of KR890009376A publication Critical patent/KR890009376A/ko
Application granted granted Critical
Publication of KR960013283B1 publication Critical patent/KR960013283B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Detergent Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

내용 없음

Description

분무 건조된 이부프로펜
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 분말의 중량을 기준으로하여, 실질적으로 약63내지 77중량%의 이부프로펜, 약25내지 40중량%의 에스틸셀룰로스 및 약2내지 7중량%의 가소제로 구성되며, 가소제가 용해되거나 현탁된 물중의 이부프로펜 및 에틸셀룰로스 분산액으로부터 분무건조된, 분무-건조된 이부프로펜의 무미한 치료용 산제.
  2. 제1항에 있어서, 에틸셀룰로스의 양이 약28내지 40중량%인 산제.
  3. 제1항 또는 2항에 있어서, 가소제가 디부틸 세바케이트인 산제.
  4. 제1항 또는 2항에 있어서, 가소제가 트리에틸 시트레이트인 산제.
  5. 10초 이내에 물에 의해 붕해될 수 있는 고체형태의 경구투여용 약제학적 용량형에 있어서, 약제학적 성분으로서 제1항 내지 제4항중 어느 한항에 따른 분무-건조된 이부프로펜의 무미한 치료용 산제를 도입시킴을 특징으로 하는 개선된 약제학적 용량형.
  6. 이부프로펜을 함유하는 고체형태의 씹는 무미한 정제형태의 경구투여용 약제학적 용량형에 있어서, 약제학적 성분으로서 제1항 내지 제4항중 어느 한항에 따른 분무-건조된 이부프로펜의 무미한 치료용 산제를 도입시킴을 특징으로 하는 개선된 약제학적 용량형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880016246A 1987-12-08 1988-12-07 분무 건조된 이부프로펜 KR960013283B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/130,718 US4835188A (en) 1987-12-08 1987-12-08 Spray dried ibuprofen
US130,718 1987-12-08
US07/130,718 1987-12-08

Publications (2)

Publication Number Publication Date
KR890009376A true KR890009376A (ko) 1989-08-01
KR960013283B1 KR960013283B1 (ko) 1996-10-02

Family

ID=22446007

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880016246A KR960013283B1 (ko) 1987-12-08 1988-12-07 분무 건조된 이부프로펜

Country Status (12)

Country Link
US (1) US4835188A (ko)
EP (1) EP0322137B1 (ko)
JP (1) JP2688614B2 (ko)
KR (1) KR960013283B1 (ko)
AT (1) ATE76575T1 (ko)
AU (1) AU609546B2 (ko)
CA (1) CA1319109C (ko)
DE (1) DE3871511D1 (ko)
ES (1) ES2031247T3 (ko)
GR (1) GR3005048T3 (ko)
IE (1) IE60652B1 (ko)
NZ (1) NZ227211A (ko)

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US4946684A (en) * 1989-06-20 1990-08-07 American Home Products Corporation Fast dissolving dosage forms
CA2063141C (en) * 1989-08-04 1997-03-04 Edward J. Roche Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
NZ234587A (en) * 1989-08-04 1991-11-26 Mcneil Ppc Inc A chewable pharmaceutical tablet of compressed coated granules
US5075114A (en) * 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
US5460825A (en) * 1990-05-23 1995-10-24 Mcneil-Ppc, Inc. Taste mask coatings for preparing chewable pharmaceutical tablets
US5260072A (en) * 1990-08-30 1993-11-09 Mcneil-Ppc, Inc. Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
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US5320848A (en) * 1991-05-28 1994-06-14 Affinity Biotech, Inc. Chewable drug-delivery composition
US5380535A (en) * 1991-05-28 1995-01-10 Geyer; Robert P. Chewable drug-delivery compositions and methods for preparing the same
US5492700A (en) * 1991-11-26 1996-02-20 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
DE4140172C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Ibuprofen enthaltendes Arzneimittel
DE4140184C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Flurbiprofen enthaltendes Arzneimittel
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DE4140185C2 (de) * 1991-12-05 1996-02-01 Alfatec Pharma Gmbh Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
US5466865A (en) * 1993-07-02 1995-11-14 Ibah, Inc. Neomorphic ibuprofen and methods of using same
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ZA964928B (en) * 1995-06-13 1997-12-10 American Home Prod Oral formulations of S(+)-etodolac.
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US7163705B2 (en) * 1998-12-15 2007-01-16 Wm. Wrigley Jr. Company Coated chewing gum product and method of making
KR100759720B1 (ko) * 2000-06-30 2007-10-04 아스텔라스세이야쿠 가부시키가이샤 구강내 속붕괴정
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DE10325989A1 (de) * 2003-06-07 2005-01-05 Glatt Gmbh Verfahren zur Herstellung von und daraus resultierende Mikropellets sowie deren Verwendung
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JP7177136B2 (ja) 2017-08-04 2022-11-22 ズーメッセンス，インコーポレイテッド 超高効率噴霧乾燥装置及びプロセス
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Also Published As

Publication number Publication date
AU2639988A (en) 1989-06-08
NZ227211A (en) 1990-07-26
GR3005048T3 (ko) 1993-05-24
DE3871511D1 (de) 1992-07-02
ES2031247T3 (es) 1992-12-01
AU609546B2 (en) 1991-05-02
US4835188A (en) 1989-05-30
ATE76575T1 (de) 1992-06-15
JPH02208A (ja) 1990-01-05
JP2688614B2 (ja) 1997-12-10
KR960013283B1 (ko) 1996-10-02
IE883583L (en) 1989-06-08
EP0322137A1 (en) 1989-06-28
EP0322137B1 (en) 1992-05-27
IE60652B1 (en) 1994-08-10
CA1319109C (en) 1993-06-15

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