DK1091975T3 - Ny cyclosporin med forbedret aktivitetsprofil - Google Patents

Ny cyclosporin med forbedret aktivitetsprofil

Info

Publication number
DK1091975T3
DK1091975T3 DK99926684T DK99926684T DK1091975T3 DK 1091975 T3 DK1091975 T3 DK 1091975T3 DK 99926684 T DK99926684 T DK 99926684T DK 99926684 T DK99926684 T DK 99926684T DK 1091975 T3 DK1091975 T3 DK 1091975T3
Authority
DK
Denmark
Prior art keywords
improved activity
activity profile
new cyclosporine
cyclosporine
new
Prior art date
Application number
DK99926684T
Other languages
Danish (da)
English (en)
Inventor
Roland M Wenger
Manfred Mutter
Thomas Ruckle
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Application granted granted Critical
Publication of DK1091975T3 publication Critical patent/DK1091975T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK99926684T 1998-07-01 1999-06-30 Ny cyclosporin med forbedret aktivitetsprofil DK1091975T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH140598 1998-07-01

Publications (1)

Publication Number Publication Date
DK1091975T3 true DK1091975T3 (da) 2006-04-18

Family

ID=4209677

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99926684T DK1091975T3 (da) 1998-07-01 1999-06-30 Ny cyclosporin med forbedret aktivitetsprofil

Country Status (14)

Country Link
US (2) USRE40987E1 (enExample)
EP (1) EP1091975B1 (enExample)
JP (1) JP4350898B2 (enExample)
CN (1) CN1218958C (enExample)
AT (1) ATE312843T1 (enExample)
AU (1) AU759480B2 (enExample)
BR (1) BR9911724A (enExample)
CA (1) CA2335903C (enExample)
DE (1) DE69928938T2 (enExample)
DK (1) DK1091975T3 (enExample)
ES (1) ES2255275T3 (enExample)
MX (1) MXPA00013019A (enExample)
PT (1) PT1091975E (enExample)
WO (1) WO2000001715A1 (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759480B2 (en) 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
AU2125300A (en) 1999-02-05 2000-08-25 Debiopharm S.A. Cyclosporin derivatives and method for the production of said derivatives
WO2002085928A2 (fr) 2001-04-20 2002-10-31 Debiopharm S.A. Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation
CA2518265A1 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US20060035821A1 (en) * 2004-08-16 2006-02-16 Hunt Kevin W Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
HRP20110169T1 (hr) * 2004-10-01 2011-04-30 Debiopharm S.A. Upotreba [d-meala]3-[etval]4-ciklosporina za liječenje infekcija hepatitisom c
CA2583494C (en) * 2004-10-01 2014-01-21 Scynexis, Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
PL1853296T3 (pl) * 2005-01-10 2012-12-31 Debiopharm Sa Zastosowanie cyklicznego undekapeptydu do wytwarzania leku do podawania w trakcie zdarzeń niedokrwienia mięśnia sercowego
KR20080059270A (ko) 2005-09-30 2008-06-26 싸이넥시스, 인크. Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물
DE602006020152D1 (de) * 2005-09-30 2011-03-31 Scynexis Inc Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
PT1957518E (pt) * 2005-10-26 2016-02-26 Astellas Pharma Inc Novos compostos peptídicos cíclicos
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
CN101511357B (zh) 2006-05-19 2011-11-02 西尼克斯公司 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用
EP2027761A1 (fr) * 2006-06-02 2009-02-25 Claude Annie Perrichon Gestion des electrons actifs
CN101108178B (zh) * 2006-07-20 2010-09-15 复旦大学 一种亲环素a抑制剂在制备抗艾滋病药物中的应用
BRPI0719189A2 (pt) * 2006-10-12 2018-08-14 Univ Kyushu Nat Univ Corp uso de ciclosporinas modificadas
WO2008069917A2 (en) * 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
EP2124992A2 (en) * 2007-01-04 2009-12-02 Debiopharm S.A. Non-immunosuppressive cyclosporin for treatment of ullrich congenital muscular dystrophy
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
KR20100017547A (ko) * 2007-05-02 2010-02-16 아스텔라스세이야쿠 가부시키가이샤 신규 시클릭 펩티드 화합물
AU2008304313B2 (en) 2007-09-26 2013-01-10 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) * 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
US9090671B2 (en) 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CA2748389A1 (en) 2008-12-31 2010-07-08 Scynexis, Inc. Derivatives of cyclosporin a
KR20110111321A (ko) * 2009-01-30 2011-10-10 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
AU2010313497B2 (en) 2009-10-30 2013-08-01 Boehringer Ingelheim International Gmbh Dosage regimens for HCV combination therapy comprising BI201335, interferon alpha and ribavirin
JP5536229B2 (ja) * 2009-12-18 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｈｃｖ併用療法
WO2011076784A2 (en) 2009-12-21 2011-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) New inhibitors of cyclophilins and uses thereof
WO2012009715A2 (en) 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012037485A2 (en) * 2010-09-16 2012-03-22 1The Johns Hopkins University Methods of inhibiting alphavirus replication and treating alphavirus infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JO3337B1 (ar) * 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
KR102011339B1 (ko) 2010-12-15 2019-08-16 콘트라빌 파마슈티컬스, 인코퍼레이티드 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2572329B1 (es) 2011-10-21 2017-08-24 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc
PT107924A (pt) 2011-10-21 2014-12-03 Abbvie Inc Tratamento de combinação de daa (eg. com abt-072 ou abt-333) para utilização no tratamento de hcv
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
AR090964A1 (es) 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
RU2016110247A (ru) 2013-08-26 2017-10-02 Энанта Фармасьютикалс, Инк. Аналоги циклоспорина для предупреждения или лечения гепатита с
CN104744570A (zh) * 2013-12-31 2015-07-01 深圳先进技术研究院 一种环孢菌素的合成方法
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection
CA3022119A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP4132558A1 (en) 2020-04-06 2023-02-15 Debiopharm International SA Alisporivir for use in human viral infections

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (enExample) 1975-11-04 1979-12-28 Sandoz Ag
US4210581A (en) 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
IE54936B1 (en) 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3047662C2 (de) 1980-12-18 1985-02-21 Karl M. Reich Maschinenfabrik GmbH, 7440 Nürtingen Puffersystem bei Einschlaggeräten
DE3260468D1 (en) 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
AU589917B2 (en) 1984-10-04 1989-10-26 Novartis Ag Monoclonal antibodies to cyclosporins
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
DE3884470T2 (de) 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
DK0484281T4 (da) 1990-11-02 2001-02-05 Novartis Ag Cyclosporiner
CN1141317C (zh) 1995-07-17 2004-03-10 碳化学公司 有抗人体免疫缺损病毒作用的环孢菌素衍生物
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
AU759480B2 (en) 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US7439277B2 (en) 2005-05-19 2008-10-21 Fina Technology, Inc. In-situ preparation of hydroperoxide functionalized rubber

Also Published As

Publication number Publication date
ATE312843T1 (de) 2005-12-15
US6927208B1 (en) 2005-08-09
PT1091975E (pt) 2006-05-31
CN1218958C (zh) 2005-09-14
EP1091975B1 (fr) 2005-12-14
JP4350898B2 (ja) 2009-10-21
CA2335903C (fr) 2009-11-10
JP2002519434A (ja) 2002-07-02
CN1308635A (zh) 2001-08-15
WO2000001715A1 (fr) 2000-01-13
DE69928938T2 (de) 2006-08-17
MXPA00013019A (es) 2003-07-14
USRE40987E1 (en) 2009-11-17
BR9911724A (pt) 2001-03-20
ES2255275T3 (es) 2006-06-16
AU759480B2 (en) 2003-04-17
CA2335903A1 (fr) 2000-01-13
AU4385699A (en) 2000-01-24
DE69928938D1 (de) 2006-01-19
EP1091975A1 (fr) 2001-04-18

Similar Documents

Publication Publication Date Title
DK1091975T3 (da) Ny cyclosporin med forbedret aktivitetsprofil
ATE264863T1 (de) 28-epirapaloge
DK1104425T3 (da) Hidtil ukendte thiazolopyrimidinforbindelser
DZ2964A1 (fr) Diphénylurées substituées nouvelles, et compositions pharmaceutiques les contenant.
MA25688A1 (fr) 2-thio-3, 5-dicyano-4-aryl-6-aminopyridines substituees et leur utilisation.
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
HUP0103265A3 (en) Cyclic prosaposin-derived peptides, pharmaceutical compositions comprising thereof and their use
DE60120712D1 (en) Kallikrein gen
DE10084671T1 (de) Pharmazeutische Zusammensetzungen
ATE398630T1 (de) Zyklische conotoxin-peptide
DE60112671D1 (de) Gebogener, elastischer Zahnregulierungsring
BG106316A (en) Ambroxol-containing lozenge
GB0028130D0 (en) Polypeptide and uses thereof
HRP20000400B1 (hr) Transmukozni pripravci levosimendana
DE69831737D1 (de) Neurotrypsin
BR9916537B1 (pt) composição de fragráncia, e, produto.
PE20399A1 (es) Muteina ob
ITMI20000293A0 (it) Derivati del 3,9-diazabiciclo [3.3.1]nonano ad attivita' analgesica
WO2001037780A8 (en) Urotensin-ii analogs
ATE251619T1 (de) 1,4-dioxacycloalkan-2-one und 1,4-dioxacycloalken-2-one
HUP0104623A3 (en) Cyclosporin solution, pharmaceutical composition comprising thereof and its use
ATE250340T1 (de) 7-methylthiooxomethyl- und 7- methylthiodioxomethyl-paclitaxele
MXPA04005226A (es) 1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion.
BR9611904A (pt) Dioxidos de ditiazol
DE69915055D1 (de) Antitumorale 1,5-diazaanthraquinone