AU759480B2 - Novel cyclosporin with improved activity profile - Google Patents

Novel cyclosporin with improved activity profile Download PDF

Info

Publication number
AU759480B2
AU759480B2 AU43856/99A AU4385699A AU759480B2 AU 759480 B2 AU759480 B2 AU 759480B2 AU 43856/99 A AU43856/99 A AU 43856/99A AU 4385699 A AU4385699 A AU 4385699A AU 759480 B2 AU759480 B2 AU 759480B2
Authority
AU
Australia
Prior art keywords
jan
meleu
solution
cyclosporin
csa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU43856/99A
Other languages
English (en)
Other versions
AU4385699A (en
Inventor
Manfred Mutter
Thomas Ruckle
Roland M. Wenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm SA
Original Assignee
Debiopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm SA filed Critical Debiopharm SA
Publication of AU4385699A publication Critical patent/AU4385699A/en
Application granted granted Critical
Publication of AU759480B2 publication Critical patent/AU759480B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU43856/99A 1998-07-01 1999-06-30 Novel cyclosporin with improved activity profile Expired AU759480B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH140598 1998-07-01
CH1405/98 1998-07-01
PCT/IB1999/001232 WO2000001715A1 (fr) 1998-07-01 1999-06-30 Nouvelle cyclosporine ayant un profil d'activite ameliore

Publications (2)

Publication Number Publication Date
AU4385699A AU4385699A (en) 2000-01-24
AU759480B2 true AU759480B2 (en) 2003-04-17

Family

ID=4209677

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43856/99A Expired AU759480B2 (en) 1998-07-01 1999-06-30 Novel cyclosporin with improved activity profile

Country Status (14)

Country Link
US (2) USRE40987E1 (enExample)
EP (1) EP1091975B1 (enExample)
JP (1) JP4350898B2 (enExample)
CN (1) CN1218958C (enExample)
AT (1) ATE312843T1 (enExample)
AU (1) AU759480B2 (enExample)
BR (1) BR9911724A (enExample)
CA (1) CA2335903C (enExample)
DE (1) DE69928938T2 (enExample)
DK (1) DK1091975T3 (enExample)
ES (1) ES2255275T3 (enExample)
MX (1) MXPA00013019A (enExample)
PT (1) PT1091975E (enExample)
WO (1) WO2000001715A1 (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759480B2 (en) 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
AU2125300A (en) 1999-02-05 2000-08-25 Debiopharm S.A. Cyclosporin derivatives and method for the production of said derivatives
WO2002085928A2 (fr) 2001-04-20 2002-10-31 Debiopharm S.A. Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation
CA2518265A1 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US20060035821A1 (en) * 2004-08-16 2006-02-16 Hunt Kevin W Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
HRP20110169T1 (hr) * 2004-10-01 2011-04-30 Debiopharm S.A. Upotreba [d-meala]3-[etval]4-ciklosporina za liječenje infekcija hepatitisom c
CA2583494C (en) * 2004-10-01 2014-01-21 Scynexis, Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
PL1853296T3 (pl) * 2005-01-10 2012-12-31 Debiopharm Sa Zastosowanie cyklicznego undekapeptydu do wytwarzania leku do podawania w trakcie zdarzeń niedokrwienia mięśnia sercowego
KR20080059270A (ko) 2005-09-30 2008-06-26 싸이넥시스, 인크. Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물
DE602006020152D1 (de) * 2005-09-30 2011-03-31 Scynexis Inc Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
PT1957518E (pt) * 2005-10-26 2016-02-26 Astellas Pharma Inc Novos compostos peptídicos cíclicos
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
CN101511357B (zh) 2006-05-19 2011-11-02 西尼克斯公司 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用
EP2027761A1 (fr) * 2006-06-02 2009-02-25 Claude Annie Perrichon Gestion des electrons actifs
CN101108178B (zh) * 2006-07-20 2010-09-15 复旦大学 一种亲环素a抑制剂在制备抗艾滋病药物中的应用
BRPI0719189A2 (pt) * 2006-10-12 2018-08-14 Univ Kyushu Nat Univ Corp uso de ciclosporinas modificadas
WO2008069917A2 (en) * 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
EP2124992A2 (en) * 2007-01-04 2009-12-02 Debiopharm S.A. Non-immunosuppressive cyclosporin for treatment of ullrich congenital muscular dystrophy
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
KR20100017547A (ko) * 2007-05-02 2010-02-16 아스텔라스세이야쿠 가부시키가이샤 신규 시클릭 펩티드 화합물
AU2008304313B2 (en) 2007-09-26 2013-01-10 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) * 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
US9090671B2 (en) 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CA2748389A1 (en) 2008-12-31 2010-07-08 Scynexis, Inc. Derivatives of cyclosporin a
KR20110111321A (ko) * 2009-01-30 2011-10-10 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
AU2010313497B2 (en) 2009-10-30 2013-08-01 Boehringer Ingelheim International Gmbh Dosage regimens for HCV combination therapy comprising BI201335, interferon alpha and ribavirin
JP5536229B2 (ja) * 2009-12-18 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｈｃｖ併用療法
WO2011076784A2 (en) 2009-12-21 2011-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) New inhibitors of cyclophilins and uses thereof
WO2012009715A2 (en) 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012037485A2 (en) * 2010-09-16 2012-03-22 1The Johns Hopkins University Methods of inhibiting alphavirus replication and treating alphavirus infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JO3337B1 (ar) * 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
KR102011339B1 (ko) 2010-12-15 2019-08-16 콘트라빌 파마슈티컬스, 인코퍼레이티드 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2572329B1 (es) 2011-10-21 2017-08-24 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc
PT107924A (pt) 2011-10-21 2014-12-03 Abbvie Inc Tratamento de combinação de daa (eg. com abt-072 ou abt-333) para utilização no tratamento de hcv
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
AR090964A1 (es) 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
RU2016110247A (ru) 2013-08-26 2017-10-02 Энанта Фармасьютикалс, Инк. Аналоги циклоспорина для предупреждения или лечения гепатита с
CN104744570A (zh) * 2013-12-31 2015-07-01 深圳先进技术研究院 一种环孢菌素的合成方法
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection
CA3022119A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP4132558A1 (en) 2020-04-06 2023-02-15 Debiopharm International SA Alisporivir for use in human viral infections

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (enExample) 1975-11-04 1979-12-28 Sandoz Ag
US4210581A (en) 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
IE54936B1 (en) 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3047662C2 (de) 1980-12-18 1985-02-21 Karl M. Reich Maschinenfabrik GmbH, 7440 Nürtingen Puffersystem bei Einschlaggeräten
DE3260468D1 (en) 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
AU589917B2 (en) 1984-10-04 1989-10-26 Novartis Ag Monoclonal antibodies to cyclosporins
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
DE3884470T2 (de) 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
DK0484281T4 (da) 1990-11-02 2001-02-05 Novartis Ag Cyclosporiner
CN1141317C (zh) 1995-07-17 2004-03-10 碳化学公司 有抗人体免疫缺损病毒作用的环孢菌素衍生物
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
AU759480B2 (en) 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US7439277B2 (en) 2005-05-19 2008-10-21 Fina Technology, Inc. In-situ preparation of hydroperoxide functionalized rubber

Also Published As

Publication number Publication date
ATE312843T1 (de) 2005-12-15
US6927208B1 (en) 2005-08-09
PT1091975E (pt) 2006-05-31
DK1091975T3 (da) 2006-04-18
CN1218958C (zh) 2005-09-14
EP1091975B1 (fr) 2005-12-14
JP4350898B2 (ja) 2009-10-21
CA2335903C (fr) 2009-11-10
JP2002519434A (ja) 2002-07-02
CN1308635A (zh) 2001-08-15
WO2000001715A1 (fr) 2000-01-13
DE69928938T2 (de) 2006-08-17
MXPA00013019A (es) 2003-07-14
USRE40987E1 (en) 2009-11-17
BR9911724A (pt) 2001-03-20
ES2255275T3 (es) 2006-06-16
CA2335903A1 (fr) 2000-01-13
AU4385699A (en) 2000-01-24
DE69928938D1 (de) 2006-01-19
EP1091975A1 (fr) 2001-04-18

Similar Documents

Publication Publication Date Title
AU759480B2 (en) Novel cyclosporin with improved activity profile
US6809077B2 (en) Cyclosporin analogs for the treatment of autoimmune diseases
US7468419B2 (en) Cyclosporin derivatives for the treatment of immune disorders
US6979671B2 (en) Cyclosporins for the treatment of immune disorders
US7012064B2 (en) Cyclosporins for the treatment of immune disorders
US6255100B1 (en) Cyclosporin fermentation process
JP4477777B2 (ja) 新規シクロスポリン
US6316405B1 (en) Cyclosporin a conjugates and uses therefor
US20040157768A1 (en) Cyclosporins for the treatment of immune disorders
CA2847486C (en) Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
AU2002245996B2 (en) Modified cyclosporine which can be used as a pro-drug and use thereof
IL226792A (en) Analogous compounds to cyclosporine are modified in amino acids 1 and 3
KR20110045032A (ko) 비면역억제성 사이클로스포린 유사체 분자
GB2207678A (en) Novel immunosuppressive fluorinated cyclosporin analogs
KR101443171B1 (ko) 프로테아제 저해 활성을 가지는 주형-고정된 β-헤어핀 구조의 펩티드모방체
Ko et al. Solid‐Phase Total Synthesis of Cyclosporine Analogues
US6270957B1 (en) Non-Imuunosuppressive cyclosporins and their use in the prevention and treatment of HIV infection
RU2085589C1 (ru) Циклоспорины
GB2227244A (en) Immunosuppressive fluorinated cyclosporin analogs
HK1161277A (en) Nonimmunosuppressive cyclosporine analogue molecules

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired