DK1089726T3 - Præparat omfattende beta-hydroxy-beta-methylsmørsyre og mindst en aminosyre - Google Patents

Præparat omfattende beta-hydroxy-beta-methylsmørsyre og mindst en aminosyre

Info

Publication number
DK1089726T3
DK1089726T3 DK99930567T DK99930567T DK1089726T3 DK 1089726 T3 DK1089726 T3 DK 1089726T3 DK 99930567 T DK99930567 T DK 99930567T DK 99930567 T DK99930567 T DK 99930567T DK 1089726 T3 DK1089726 T3 DK 1089726T3
Authority
DK
Denmark
Prior art keywords
beta
hydroxy
composition
acid
amino acid
Prior art date
Application number
DK99930567T
Other languages
Danish (da)
English (en)
Inventor
Steven L Nissen
Naji M Abumrad
Original Assignee
Univ Iowa State Res Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22292520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1089726(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Iowa State Res Found Inc filed Critical Univ Iowa State Res Found Inc
Application granted granted Critical
Publication of DK1089726T3 publication Critical patent/DK1089726T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DK99930567T 1998-06-23 1999-06-23 Præparat omfattende beta-hydroxy-beta-methylsmørsyre og mindst en aminosyre DK1089726T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/102,941 US6031000A (en) 1998-06-23 1998-06-23 Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use
PCT/US1999/014097 WO1999066917A2 (en) 1998-06-23 1999-06-23 Composition comprising ss-hydroxy-ss-methylbutyric acid and at least one amino acid

Publications (1)

Publication Number Publication Date
DK1089726T3 true DK1089726T3 (da) 2002-07-22

Family

ID=22292520

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99930567T DK1089726T3 (da) 1998-06-23 1999-06-23 Præparat omfattende beta-hydroxy-beta-methylsmørsyre og mindst en aminosyre

Country Status (12)

Country Link
US (1) US6031000A (de)
EP (1) EP1089726B1 (de)
JP (2) JP5064609B2 (de)
AU (1) AU756353B2 (de)
CA (1) CA2334761C (de)
DE (1) DE69901396T2 (de)
DK (1) DK1089726T3 (de)
ES (1) ES2177293T3 (de)
NO (2) NO329914B1 (de)
NZ (1) NZ508395A (de)
PL (1) PL195623B1 (de)
WO (1) WO1999066917A2 (de)

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JP3362350B2 (ja) * 1997-10-16 2003-01-07 味の素株式会社 反芻動物の肥育方法
US20040220266A1 (en) * 2002-09-09 2004-11-04 Wiley David B. Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US20040106678A1 (en) * 2002-09-17 2004-06-03 Dobbins Thomas A Compositions for the parenteral administration of calcium and magnesium
US6812249B2 (en) * 2003-03-04 2004-11-02 Sal Abraham Process for preparing a 3-hydroxy-3-methylbutyrate amino acid salt and method of use
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
WO2007056176A2 (en) * 2005-11-03 2007-05-18 Southwest Immunology, Inc. Compositions for preventing and reducing delayed onset muscle soreness
ES2363442T3 (es) * 2005-11-30 2011-08-04 Nestec S.A. Combinación que comprende al menos una aminoácido y un inhibidor de pkr para utilizar en el tratamiento de la pérdida de masa muscular.
AU2006331950A1 (en) * 2005-12-19 2007-07-05 Abbott Laboratories Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance of type 1 and type 2 cytokine production
US7754693B2 (en) * 2006-02-16 2010-07-13 Young Hee Ko Composition and method for the efficacious and safe administration of halopyruvate for the treatment of cancer
US8324175B2 (en) 2006-02-16 2012-12-04 Young Hee Ko Compositions and methods for the treatment of cancer
US11173167B2 (en) 2008-12-09 2021-11-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9707241B2 (en) 2008-12-09 2017-07-18 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9539224B2 (en) * 2008-12-09 2017-01-10 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
PT2381784T (pt) * 2008-12-09 2018-10-30 Metabolic Tech Inc Intervenção nutricional para melhorar função e força muscular
US9259430B2 (en) 2008-12-09 2016-02-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9770424B2 (en) * 2008-12-09 2017-09-26 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
CN102387801A (zh) * 2009-01-29 2012-03-21 高荣禧 癌症治疗用组合物和方法
EP2289555A1 (de) * 2009-08-24 2011-03-02 OrgaNext Research B.V. Verfahren zur Behandlung von Gebrechlichkeit
EP2512236B1 (de) * 2009-12-18 2016-10-19 Metabolic Technologies, Inc. Verbessertes verfahren zur verabreichung von beta-hydroxy-beta-methylbutyrat (hmb)
PE20121729A1 (es) 2010-01-29 2013-01-16 Abbott Lab Emulsiones nutricionales que comprenden beta-hidroxi-beta-metilbutirato (hmb) de calcio
WO2011094548A1 (en) 2010-01-29 2011-08-04 Abbott Laboratories Aseptically packaged nutritional liquids comprising hmb
US9693577B2 (en) 2010-01-29 2017-07-04 Abbott Laboratories Method of preparing a nutritional powder comprising spray dried HMB
TWI526161B (zh) 2010-06-10 2016-03-21 亞培公司 包含鈣ｈｍｂ及可溶性蛋白質之實質上透明營養液
WO2013012760A1 (en) 2011-07-15 2013-01-24 Numeta Sciences, Inc. Compositions and methods for modulating metabolic pathways
EP2773363A1 (de) 2011-11-03 2014-09-10 University of Florida Research Foundation, Inc. Nahrungsergänzung zur gewichtskontrolle
EP2782588B1 (de) * 2011-11-21 2020-04-15 Emmaus Medical, Inc. Verfahren und zusammensetzungen zur behandlung von diabetes und zugehöriger symptome
US10064835B2 (en) 2012-01-11 2018-09-04 Abbott Laboratories Combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine for use in treating diabetic ulcers
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
CN105025891B (zh) 2012-09-10 2020-01-21 代谢科技有限公司 Hmb和atp的组合物及使用方法
BR112015006426A2 (pt) 2012-09-21 2017-07-04 Abbott Lab composições nutricionais que incluem beta-hidróxi-beta-metilbutirato de cálcio, proteína e baixos níveis de eletrólitos
WO2014047493A1 (en) * 2012-09-21 2014-03-27 Abbott Laboratories Nutritional compositions including calcium beta-hydroxy-beta-methylbutyrate and protein
CA2891335C (en) 2012-11-13 2021-05-04 Nusirt Sciences, Inc. Compositions and methods for increasing energy metabolism
WO2014152606A2 (en) * 2013-03-14 2014-09-25 Abbott Laboratories Treatment of insulin resistance associated with prolonged physical inactivity
CA2902879C (en) 2013-03-15 2023-09-26 Nusirt Sciences, Inc. Leucine and nicotinic acid reduces lipid levels
US20150057350A1 (en) * 2013-08-23 2015-02-26 Abbott Laboratories Fibrosis biomarkers and methods of using same
KR20160119863A (ko) 2014-02-27 2016-10-14 뉴서트 사이언시스, 인크. 간 지방증의 감소 또는 예방을 위한 조성물 및 방법
MX2017015418A (es) * 2015-06-01 2018-08-24 Metabolic Tech Inc Composiciones y metodos de uso de beta-hidroxi-beta-metilbutirato (hmb) para reducir grasa corporal.
JP7114458B2 (ja) 2015-09-16 2022-08-08 メタボリック・テクノロジーズ，インコーポレーテッド 軟組織外傷からの回復を増強するためのβ－ヒドロキシ－β－メチルブチレート（ＨＭＢ）の組成物および使用方法
EP3385250B1 (de) * 2015-11-19 2021-10-20 Kyowa Hakko Bio Co., Ltd. Kristalle von monovalentem kationensalz von 3-hydroxyisovaleriansäure und verfahren zur herstellung der besagten kristalle
AU2017210335A1 (en) 2016-01-21 2018-08-02 Metabolic Technololgies, Inc. Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for modulating autophagy and lipophagy
US11026929B2 (en) 2016-04-19 2021-06-08 Keto Patent Group, Inc. Administration of berberine metabolites
CA3021784A1 (en) * 2016-04-19 2017-10-26 Keto Patent Group, Inc. Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans
AU2017282515A1 (en) 2016-06-24 2019-01-17 Otsuka Pharmaceutical Factory, Inc. Crystal of β-hydroxy β-methylbutyric acid amino acid salt and production method therefor
CA3041520A1 (en) 2016-10-21 2018-04-26 Metabolic Technologies, Inc. Compositions and methods of use of .beta.-hydroxy-.beta.-methylbutyrate (hmb) and probiotics
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
PE20200747A1 (es) 2017-08-14 2020-07-24 Axcella Health Inc Composiciones de aminoacidos para el tratamiento de enfermedad hepatica
JP2021509686A (ja) * 2018-01-05 2021-04-01 テキサス・テック・ユニバーシティー・オフィス・オブ・リサーチ・コマーシャライゼーション 間欠性絶食に関連するβ−ヒドロキシ−β−メチルブチレート（ＨＭＢ）の組成物およびその使用法
MA52971A (fr) 2018-06-20 2021-04-28 Axcella Health Inc Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle

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Also Published As

Publication number Publication date
WO1999066917A3 (en) 2000-04-20
ES2177293T3 (es) 2002-12-01
DE69901396D1 (de) 2002-06-06
EP1089726A2 (de) 2001-04-11
CA2334761C (en) 2009-04-28
AU4708099A (en) 2000-01-10
NO20101440L (no) 2001-02-20
NO20006633L (no) 2001-02-20
NZ508395A (en) 2003-09-26
DE69901396T2 (de) 2002-08-29
WO1999066917A2 (en) 1999-12-29
PL195623B1 (pl) 2007-10-31
EP1089726B1 (de) 2002-05-02
NO20006633D0 (no) 2000-12-22
JP2012102118A (ja) 2012-05-31
US6031000A (en) 2000-02-29
AU756353B2 (en) 2003-01-09
JP5064609B2 (ja) 2012-10-31
JP5690261B2 (ja) 2015-03-25
NO329914B1 (no) 2011-01-24
NO332374B1 (no) 2012-09-10
PL344589A1 (en) 2001-11-05
CA2334761A1 (en) 1999-12-29
JP2002518440A (ja) 2002-06-25

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