DE69928270D1 - Neutraler aminosäurentransporter und korrespondierendes gen - Google Patents

Neutraler aminosäurentransporter und korrespondierendes gen

Info

Publication number
DE69928270D1
DE69928270D1 DE69928270T DE69928270T DE69928270D1 DE 69928270 D1 DE69928270 D1 DE 69928270D1 DE 69928270 T DE69928270 T DE 69928270T DE 69928270 T DE69928270 T DE 69928270T DE 69928270 D1 DE69928270 D1 DE 69928270D1
Authority
DE
Germany
Prior art keywords
amino acid
neutral amino
acid transport
corresponding gen
gen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928270T
Other languages
English (en)
Other versions
DE69928270T2 (de
Inventor
Hitoshi Endou
Yoshikatsu Kanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J Pharma Co Ltd
Original Assignee
Japan Science and Technology Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Agency filed Critical Japan Science and Technology Agency
Application granted granted Critical
Publication of DE69928270D1 publication Critical patent/DE69928270D1/de
Publication of DE69928270T2 publication Critical patent/DE69928270T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69928270T 1998-09-03 1999-09-03 Neutraler aminosäurentransporter und korrespondierendes gen Expired - Lifetime DE69928270T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP24999398 1998-09-03
JP24999398 1998-09-03
JP24854699A JP4689781B2 (ja) 1998-09-03 1999-09-02 アミノ酸輸送蛋白及びその遺伝子
JP24854699 1999-09-02
PCT/JP1999/004789 WO2000014228A1 (fr) 1998-09-03 1999-09-03 Transporteur d'acides amines neutres et gene correspondant

Publications (2)

Publication Number Publication Date
DE69928270D1 true DE69928270D1 (de) 2005-12-15
DE69928270T2 DE69928270T2 (de) 2006-08-03

Family

ID=26538829

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928270T Expired - Lifetime DE69928270T2 (de) 1998-09-03 1999-09-03 Neutraler aminosäurentransporter und korrespondierendes gen

Country Status (7)

Country Link
US (6) US7332572B1 (de)
EP (1) EP1111048B1 (de)
JP (1) JP4689781B2 (de)
AU (1) AU766306B2 (de)
CA (1) CA2341777C (de)
DE (1) DE69928270T2 (de)
WO (1) WO2000014228A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4750222B2 (ja) * 1998-09-03 2011-08-17 独立行政法人科学技術振興機構 アミノ酸輸送蛋白及びその遺伝子
JP4689781B2 (ja) * 1998-09-03 2011-05-25 独立行政法人科学技術振興機構 アミノ酸輸送蛋白及びその遺伝子
GB0024444D0 (en) * 2000-10-05 2000-11-22 Glaxo Group Ltd Novel protein
AU2002310256A1 (en) * 2001-06-05 2002-12-16 Exelixis Inc. Ppp2cs as modifiers of the p53 pathway and methods of use
CA2633413C (en) 2001-06-20 2012-08-21 Genentech, Inc. Antibodies against tumor-associated antigenic target (tat) polypeptides
US20050272120A1 (en) 2001-06-20 2005-12-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7803915B2 (en) * 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
DE60236307D1 (de) 2001-09-28 2010-06-17 Pharma Co Ltd J Erender natriumunabhängiger transporter, dessen gen mittels konstruktion von die spezifizierung der funktion ermöglichenden fusionsproteinen
JP4278906B2 (ja) * 2002-02-18 2009-06-17 ジェイファーマ株式会社 酸性アミノ酸を輸送するナトリウム非依存性トランスポーター及びその遺伝子
EP1499741A4 (de) * 2002-03-13 2006-07-05 Univ Creighton Vorrichtung und verfahren zum nachweis antibiotisch-inaktivierender enzyme
EP1483962A3 (de) * 2003-06-06 2005-01-12 F. Hoffmann-La Roche Ag Transgenes Tiermodel für Glyt1 Funktion
CA2469992A1 (en) * 2003-06-06 2004-12-06 F. Hoffmann-La Roche Ag Transgenic animal model for glyt1 function
DK2489364T3 (en) 2003-11-06 2015-03-02 Seattle Genetics Inc Monomethylvaline compounds conjugated to antibodies
US7462459B2 (en) * 2004-01-30 2008-12-09 Xenoport, Inc. LAT1 transporters expressed in blood brain barrier cells
JP4560314B2 (ja) * 2004-03-17 2010-10-13 ジェイファーマ株式会社 中性アミノ酸トランスポーターによる癌の検出法、及びそのためのキット
AU2005249490B2 (en) 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
US20060003920A1 (en) * 2004-06-04 2006-01-05 Xenoport, Inc. LAT1 transporters expressed in cancer cells
AU2005286607B2 (en) 2004-09-23 2011-01-27 Genentech, Inc. Cysteine engineered antibodies and conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
WO2007084715A2 (en) * 2006-01-19 2007-07-26 Caprion Pharmaceuticals, Inc. Tat-031 and methods of assessing and treating cancer
TWI390034B (zh) 2006-04-06 2013-03-21 Kyowa Hakko Kirin Co Ltd Novel anti-CD98 antibody
CN105372425A (zh) * 2007-02-06 2016-03-02 J制药股份有限公司 前列腺癌的恶性程度判定试剂盒和其方法
JPWO2008096416A1 (ja) * 2007-02-06 2010-05-20 ジェイファーマ株式会社 前立腺がんの悪性度判定キット及びその方法
US7935494B2 (en) * 2007-03-01 2011-05-03 Carnegie Institution Of Washington Trp/his exchange and kynurenine induced Trp transport
RU2523419C2 (ru) 2008-07-15 2014-07-20 Дженетек, Инк. Конъюгаты производного антрациклина, способы их получения и их применение в качестве противоопухолевых соединений
EP2459064A1 (de) * 2009-07-27 2012-06-06 Cardiac Pacemakers, Inc. Medizinische vorrichtung zur behandlung von herzinsuffizienz mittels umverteilung des blutvolumens
CA2809819A1 (en) 2009-09-09 2011-03-17 Centrose, Llc Extracellular targeted drug conjugates
CN103038255A (zh) 2010-03-26 2013-04-10 国立大学法人德岛大学 新抗cd98抗体及其用途
US9021394B2 (en) * 2010-04-01 2015-04-28 Eventsq Llc Capturing user feedback of software content in a networked environment and controlling the software using a single action
EP2528625B1 (de) 2010-04-15 2013-07-10 Spirogen Sàrl Pyrrolobenzodiazepine und konjugate daraus
CA2799540A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
JP5866138B2 (ja) * 2010-10-28 2016-02-17 幸雄 米田 骨粗鬆症の予防及び/又は治療剤、骨吸収抑制剤、骨形成促進剤及びそれらのスクリーニング方法
CN103313990B (zh) 2010-11-17 2016-07-20 基因泰克公司 丙氨酰美登醇抗体偶联物
KR101976219B1 (ko) 2011-04-15 2019-05-07 제이 파마 가부시끼가이샤 유방암의 바이오마커
WO2012155019A1 (en) 2011-05-12 2012-11-15 Genentech, Inc. Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides
BR112014009050B1 (pt) 2011-10-14 2022-06-21 Medimmune Limited Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
NZ707490A (en) 2012-10-12 2018-09-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
CA2887894C (en) 2012-10-12 2019-10-29 Adc Therapeutics Sarl Pyrrolobenzodiazepine - anti-psma antibody conjugates
LT2839860T (lt) 2012-10-12 2019-07-10 Medimmune Limited Pirolobenzodiazepinai ir jų konjugatai
NZ707534A (en) 2012-10-12 2018-08-31 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
KR101995620B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
JP2013063978A (ja) * 2012-10-24 2013-04-11 J-Pharma Co Ltd 抗ヒトlat1モノクローナル抗体及び前立腺がんの悪性度判定キット
AU2013366493B2 (en) 2012-12-21 2017-08-24 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EA032986B1 (ru) 2012-12-21 2019-08-30 Медимьюн Лимитед Пирролобензодиазепины
TWI680766B (zh) 2013-03-13 2020-01-01 英商梅迪繆思有限公司 吡咯并苯并二氮呯及其共軛物
JP6340019B2 (ja) 2013-03-13 2018-06-06 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピン及びそのコンジュゲート
BR112015023333A8 (pt) 2013-03-13 2018-04-17 Medimmune Ltd pirrolbenzodiazepinas e conjugados dos mesmos
KR20160042080A (ko) 2013-08-12 2016-04-18 제넨테크, 인크. 1-(클로로메틸)-2,3-디히드로-1H-벤조[e]인돌 이량체 항체-약물 접합체 화합물, 및 사용 및 치료 방법
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP3054985B1 (de) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepin-antikörper-konjugate
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
MX2016007578A (es) 2013-12-16 2016-10-03 Genentech Inc Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento.
MX371092B (es) 2013-12-16 2020-01-16 Genentech Inc Compuestos peptidomimeticos y conjugados de anticuerpo-farmaco de los mismos.
BR112016013861A2 (pt) 2013-12-16 2017-10-10 Genentech Inc conjugados de droga e anticorpo, compostos, método de tratamento e composição farmacêutica
JP6531166B2 (ja) 2014-09-10 2019-06-12 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピン及びそのコンジュゲート
US10149913B2 (en) 2014-09-12 2018-12-11 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
TW201625688A (zh) 2014-09-12 2016-07-16 建南德克公司 經半胱胺酸改造之抗體及接合物
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
PE20170905A1 (es) 2014-09-17 2017-07-12 Genentech Inc Pirrolobenzodiazepinas y conjugados de anticuerpo-disulfuro de las mismas
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
WO2016090050A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
JP2015134778A (ja) * 2015-02-06 2015-07-27 ジェイファーマ株式会社 抗ヒトlat1モノクローナル抗体及び前立腺がんの悪性度判定キット
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN108700598A (zh) 2016-03-25 2018-10-23 豪夫迈·罗氏有限公司 多路总抗体和抗体缀合的药物量化测定法
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
EP3465221B1 (de) 2016-05-27 2020-07-22 H. Hoffnabb-La Roche Ag Bioanalytisches verfahren zur charakterisierung von ortsspezifischen antikörper-wirkstoff-konjugaten
US10639378B2 (en) 2016-06-06 2020-05-05 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
CN109689111B (zh) 2016-08-11 2024-04-05 基因泰克公司 吡咯并苯并二氮杂䓬前药及其抗体缀合物
EP3522933B1 (de) 2016-10-05 2021-12-15 F. Hoffmann-La Roche AG Verfahren zur herstellung von antikörperarzneimittelkonjugaten
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
PT3544636T (pt) 2017-02-08 2021-05-04 Medimmune Ltd Conjugados de anticorpos-pirrolobenzodiazepinas
HUE059828T2 (hu) 2017-04-18 2023-01-28 Medimmune Ltd Pirrolobenzodiazepin konjugátumok
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
SI3668874T1 (sl) 2017-08-18 2022-04-29 Medimmune Limited Pirolobenzodiazepinski konjugati
KR20220156974A (ko) 2017-09-20 2022-11-28 주식회사 피에이치파마 타일란스타틴 유사체
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
AU2019365238A1 (en) 2018-10-24 2021-05-13 F. Hoffmann-La Roche Ag Conjugated chemical inducers of degradation and methods of use
JP2022513198A (ja) 2018-12-10 2022-02-07 ジェネンテック, インコーポレイテッド Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
JPH04157192A (ja) * 1990-10-19 1992-05-29 Fuji Photo Film Co Ltd 銀回収装置
US5695751A (en) * 1993-04-08 1997-12-09 Cornell Research Foundation, Inc. Enhancing delivery of large neutral amino acid drugs
EP0843961B1 (de) * 1995-08-29 2007-01-24 Kirin Beer Kabushiki Kaisha Chimäres tier und methode zu dessen herstellung
US5843727A (en) * 1997-04-08 1998-12-01 Incyte Pharmacuticals, Inc. Polynucleotides encoding a human tumor-associated membrane protein
JP4689781B2 (ja) * 1998-09-03 2011-05-25 独立行政法人科学技術振興機構 アミノ酸輸送蛋白及びその遺伝子

Also Published As

Publication number Publication date
US20050003490A1 (en) 2005-01-06
US20050064475A1 (en) 2005-03-24
AU766306B2 (en) 2003-10-16
US20120083588A1 (en) 2012-04-05
EP1111048A4 (de) 2001-11-21
EP1111048B1 (de) 2005-11-09
US20050019811A1 (en) 2005-01-27
WO2000014228A1 (fr) 2000-03-16
DE69928270T2 (de) 2006-08-03
AU5448799A (en) 2000-03-27
US7666999B2 (en) 2010-02-23
JP2000157286A (ja) 2000-06-13
US20050019812A1 (en) 2005-01-27
CA2341777C (en) 2013-01-08
JP4689781B2 (ja) 2011-05-25
US7332572B1 (en) 2008-02-19
CA2341777A1 (en) 2000-03-16
US7332293B2 (en) 2008-02-19
WO2000014228A8 (fr) 2000-05-25
US7335482B2 (en) 2008-02-26
EP1111048A2 (de) 2001-06-27
US7413895B2 (en) 2008-08-19

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Owner name: J-PHARMA CO.,LTD., TOKYO, JP