DK1084136T3 - Adskillelse af monomere af et antistof fra dets multimere ved anvendelse af ionbytterchromatografi - Google Patents
Adskillelse af monomere af et antistof fra dets multimere ved anvendelse af ionbytterchromatografiInfo
- Publication number
- DK1084136T3 DK1084136T3 DK99925856T DK99925856T DK1084136T3 DK 1084136 T3 DK1084136 T3 DK 1084136T3 DK 99925856 T DK99925856 T DK 99925856T DK 99925856 T DK99925856 T DK 99925856T DK 1084136 T3 DK1084136 T3 DK 1084136T3
- Authority
- DK
- Denmark
- Prior art keywords
- multimers
- monomers
- exchange chromatography
- antibody
- separation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8760298P | 1998-06-01 | 1998-06-01 | |
EP99925856A EP1084136B1 (fr) | 1998-06-01 | 1999-05-24 | Separation des monomeres d'un anticorps de ses multimeres par l'utilisation de la chromatographie echangeuse d'ions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1084136T3 true DK1084136T3 (da) | 2005-01-03 |
Family
ID=22206161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99925856T DK1084136T3 (da) | 1998-06-01 | 1999-05-24 | Adskillelse af monomere af et antistof fra dets multimere ved anvendelse af ionbytterchromatografi |
Country Status (13)
Country | Link |
---|---|
US (2) | US6620918B2 (fr) |
EP (2) | EP1500661A1 (fr) |
JP (3) | JP2002517406A (fr) |
AT (1) | ATE274522T1 (fr) |
AU (1) | AU750977B2 (fr) |
CA (1) | CA2333747C (fr) |
DE (1) | DE69919701T2 (fr) |
DK (1) | DK1084136T3 (fr) |
ES (1) | ES2228052T3 (fr) |
HK (1) | HK1037879A1 (fr) |
IL (2) | IL139609A (fr) |
PT (1) | PT1084136E (fr) |
WO (1) | WO1999062936A1 (fr) |
Families Citing this family (49)
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DE69943205D1 (de) * | 1998-08-06 | 2011-03-31 | Mountain View Pharmaceuticals | Peg-uricase Konjugate und Verwendung davon |
US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
AU2003901507A0 (en) * | 2003-03-28 | 2003-04-17 | Norika Holdings | Process for isolating a pharmaceutical product |
WO2005000901A2 (fr) * | 2003-05-09 | 2005-01-06 | Duke University | Anticorps specifiques de cd20 et leurs methodes d'utilisation |
US20050065136A1 (en) * | 2003-08-13 | 2005-03-24 | Roby Russell R. | Methods and compositions for the treatment of infertility using dilute hormone solutions |
WO2005077130A2 (fr) * | 2004-02-11 | 2005-08-25 | Tanox, Inc. | Procede d'elimination de proteines agregees a partir d'echantillons recombines a l'aide de la chromatographie par echanges d'ions |
WO2005105106A2 (fr) * | 2004-04-21 | 2005-11-10 | Roby Russell R | Traitement hormonal de la degenerescence maculaire |
US20060025390A1 (en) * | 2004-07-28 | 2006-02-02 | Roby Russell R | Treatment of hormone allergy and related symptoms and disorders |
KR20070072510A (ko) * | 2004-08-30 | 2007-07-04 | 론자 바이올로직스 피엘씨 | 항체 정제를 위한 친화도- 및 이온 교환- 크로마토그래피 |
JP4498186B2 (ja) * | 2005-03-24 | 2010-07-07 | 株式会社日立ハイテクノロジーズ | 液体クロマトグラフ分析方法及び装置 |
CA2604399A1 (fr) | 2005-04-11 | 2006-10-19 | Savient Pharmaceuticals, Inc. | Formes variantes de l'urate oxydase et leur utilisation |
US8148123B2 (en) * | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
CZ2007700A3 (cs) | 2005-04-11 | 2008-02-27 | Savient Pharmaceuticals, Inc. | Variantní forma urátoxidázy a její použití |
US9534013B2 (en) * | 2006-04-12 | 2017-01-03 | Horizon Pharma Rheumatology Llc | Purification of proteins with cationic surfactant |
WO2006125452A1 (fr) * | 2005-05-23 | 2006-11-30 | Universite De Geneve | Nanoparticules superparamagnetiques injectables destinees a un traitement par hyperthermie et a la formation d'un implant |
TWI391399B (zh) * | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
TWI423986B (zh) | 2005-12-20 | 2014-01-21 | 必治妥美雅史谷比公司 | 組合物及製造組合物之方法 |
BRPI0621124A2 (pt) | 2005-12-22 | 2011-11-29 | Genentech Inc | métodos para recuperação de uma proteìna de ligação à heparina |
JPWO2007123242A1 (ja) * | 2006-04-25 | 2009-09-10 | 東ソー株式会社 | IgG精製用分離剤、及びそれを用いたIgG単量体の精製方法 |
WO2008008975A2 (fr) | 2006-07-14 | 2008-01-17 | Genentech, Inc. | Repliement de protéines recombinantes |
JP2010501623A (ja) | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Fc含有タンパク質の精製法 |
WO2008117735A1 (fr) | 2007-03-23 | 2008-10-02 | Asahi Kasei Pharma Corporation | Procédé de fabrication de thrombomoduline soluble de pureté élevée |
ITLU20070007A1 (it) * | 2007-05-07 | 2008-11-08 | Kedrion Spa | Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand. |
MX2009012786A (es) | 2007-06-01 | 2009-12-10 | Hoffmann La Roche | Purificacion de inmunoglobulina. |
EP2226331A4 (fr) | 2007-10-26 | 2012-02-08 | Asahi Kasei Chemicals Corp | Methode de purification de proteines |
KR20150008503A (ko) | 2007-10-30 | 2015-01-22 | 제넨테크, 인크. | 양이온 교환 크로마토그래피에 의한 항체 정제 |
CN102264392A (zh) | 2008-12-22 | 2011-11-30 | 弗·哈夫曼-拉罗切有限公司 | 免疫球蛋白纯化 |
KR101861547B1 (ko) | 2009-06-25 | 2018-07-02 | 크레알타 파마슈티칼스 엘엘씨 | 페길화된 유리카아제 치료 중에 혈청 요산을 모니터링하여 주입 반응의 위험성 및 반응의 항체매개 상실을 예측하는 방법 및 키트 |
US9441011B2 (en) | 2009-07-03 | 2016-09-13 | Asahi Kasei Chemicals Corporation | Method for purification of antibody using porous membrane having amino group and alkyl group both bound to graft chain immobilized on porous substrate |
CN102639553A (zh) | 2009-11-24 | 2012-08-15 | 诺沃—诺迪斯克保健股份有限公司 | 纯化聚乙二醇化蛋白质的方法 |
SG10201408384PA (en) | 2009-12-18 | 2015-01-29 | Novartis Ag | Wash solution and method for affinity chromatography |
KR20120132529A (ko) | 2010-04-14 | 2012-12-05 | 에프. 호프만-라 로슈 아게 | 면역글로불린 응집물 제거 |
CN101948528B (zh) * | 2010-09-26 | 2012-02-01 | 广东工业大学 | 一种来自斑蝥的纤溶活性蛋白及其制备方法和应用 |
SG193378A1 (en) | 2011-03-16 | 2013-10-30 | Hoffmann La Roche | Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase |
PL221899B1 (pl) * | 2011-05-06 | 2016-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną | Czysta albumina oraz sposób jej otrzymywania i detekcji |
SG10201701224UA (en) | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
KR101516054B1 (ko) * | 2012-11-21 | 2015-05-06 | 씨제이헬스케어 주식회사 | 신규한 지속형 인간 성장호르몬 단량체를 제조하는 방법 |
CN105073769B (zh) | 2013-03-14 | 2019-09-10 | Emd密理博公司 | 利用基于a蛋白的色谱增加蛋白纯度的方法 |
AR096713A1 (es) * | 2013-06-25 | 2016-01-27 | Cadila Healthcare Ltd | Proceso de purificación para anticuerpos monoclonales |
SG10201804200WA (en) | 2013-12-12 | 2018-07-30 | Emd Millipore Corp | Protein separations using an acrylamide containing filter |
EP3603764B1 (fr) * | 2015-04-28 | 2022-03-30 | Hybio Pharmaceutical Co., Ltd. | Methode de chromatographie liquide a haute performance pour des melanges de polypeptides |
JP2018524595A (ja) * | 2015-07-14 | 2018-08-30 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 統合失調症の診断で使用するためのペプチドの組み合わせ |
JP6749590B2 (ja) * | 2015-09-17 | 2020-09-02 | 国立大学法人 東京大学 | 酸化型及び還元型アルブミンの分析方法、酸化型及び還元型アルブミンの分析装置、及び酸化型及び還元型アルブミンの分析キット |
SG11202009629YA (en) | 2018-04-02 | 2020-10-29 | Amgen Inc | Erenumab compositions and uses thereof |
WO2022207615A1 (fr) | 2021-03-31 | 2022-10-06 | F. Hoffmann-La Roche Ag | Purification d'anticorps par chromatographie en mode mixte |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4228154A (en) * | 1979-02-26 | 1980-10-14 | Armour Pharmaceutical Company | Purification of plasma albumin by ion exchange chromatography |
FR2548670B1 (fr) * | 1983-07-07 | 1985-10-25 | Merieux Inst | Procede de preparation des principales proteines du sang hemolyse sous forme non denaturee |
US5196323A (en) * | 1985-04-27 | 1993-03-23 | Boehringer Ingelheim International Gmbh | Process for preparing and purifying alpha-interferon |
US4765903A (en) * | 1987-10-06 | 1988-08-23 | Interferon Sciences, Inc. | Purification of monomeric interferon |
DE69133399T2 (de) * | 1990-04-19 | 2005-06-30 | Bayer Corp. | Methode zur Herstellung von im Wesentlichen monomeren normalen menschlichen Serum-Albumin |
US5250663A (en) * | 1990-04-19 | 1993-10-05 | Miles Inc. | Preparing essentially monomeric normal human serum albumin |
US5110913A (en) | 1990-05-25 | 1992-05-05 | Miles Inc. | Antibody purification method |
US5256294A (en) * | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
US5231178A (en) | 1991-01-16 | 1993-07-27 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Method for the purification of intact, correctly-folded insulin-like growth factor-1 |
DE4110974A1 (de) * | 1991-04-05 | 1992-10-08 | Bayer Ag | Hochkautschukhaltige polymerkombinationen |
JPH07285885A (ja) * | 1994-04-21 | 1995-10-31 | Kyodo Nyugyo Kk | 免疫グロブリンの製造法 |
AU6167596A (en) | 1995-06-07 | 1996-12-30 | Chiron Corporation | Methods for purifying authentic igf from yeast hosts |
TW505655B (en) * | 1997-10-14 | 2002-10-11 | Tanox Inc | Enhanced aggregate removal from bulk-biologicals using ion exchange chromatography |
DE69936946T2 (de) | 1998-05-06 | 2008-05-15 | Genentech, Inc., South San Francisco | Reinigung von Antikörpern durch Ionenaustauschchromatographie |
-
1999
- 1999-05-24 CA CA002333747A patent/CA2333747C/fr not_active Expired - Fee Related
- 1999-05-24 WO PCT/US1999/011598 patent/WO1999062936A1/fr not_active Application Discontinuation
- 1999-05-24 AT AT99925856T patent/ATE274522T1/de not_active IP Right Cessation
- 1999-05-24 ES ES99925856T patent/ES2228052T3/es not_active Expired - Lifetime
- 1999-05-24 EP EP04017970A patent/EP1500661A1/fr not_active Withdrawn
- 1999-05-24 JP JP2000552146A patent/JP2002517406A/ja not_active Ceased
- 1999-05-24 DE DE69919701T patent/DE69919701T2/de not_active Revoked
- 1999-05-24 PT PT99925856T patent/PT1084136E/pt unknown
- 1999-05-24 EP EP99925856A patent/EP1084136B1/fr not_active Revoked
- 1999-05-24 DK DK99925856T patent/DK1084136T3/da active
- 1999-05-24 IL IL139609A patent/IL139609A/en not_active IP Right Cessation
- 1999-05-26 US US09/320,100 patent/US6620918B2/en not_active Expired - Lifetime
- 1999-05-26 AU AU42059/99A patent/AU750977B2/en not_active Ceased
-
2001
- 2001-09-21 HK HK01106713A patent/HK1037879A1/xx not_active IP Right Cessation
-
2003
- 2003-08-15 US US10/642,409 patent/US20040116674A1/en not_active Abandoned
-
2004
- 2004-01-08 JP JP2004003506A patent/JP2004175806A/ja not_active Withdrawn
-
2005
- 2005-09-22 JP JP2005276944A patent/JP2006071646A/ja active Pending
-
2006
- 2006-01-30 IL IL173432A patent/IL173432A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2006071646A (ja) | 2006-03-16 |
AU4205999A (en) | 1999-12-20 |
AU750977B2 (en) | 2002-08-01 |
JP2002517406A (ja) | 2002-06-18 |
ES2228052T3 (es) | 2005-04-01 |
JP2004175806A (ja) | 2004-06-24 |
DE69919701D1 (de) | 2004-09-30 |
EP1084136B1 (fr) | 2004-08-25 |
HK1037879A1 (en) | 2002-02-22 |
ATE274522T1 (de) | 2004-09-15 |
IL139609A (en) | 2006-06-11 |
US20020010319A1 (en) | 2002-01-24 |
EP1084136A1 (fr) | 2001-03-21 |
CA2333747A1 (fr) | 1999-12-09 |
US20040116674A1 (en) | 2004-06-17 |
DE69919701T2 (de) | 2005-09-15 |
EP1500661A1 (fr) | 2005-01-26 |
CA2333747C (fr) | 2008-02-19 |
IL173432A0 (en) | 2006-06-11 |
IL139609A0 (en) | 2002-02-10 |
WO1999062936A1 (fr) | 1999-12-09 |
US6620918B2 (en) | 2003-09-16 |
PT1084136E (pt) | 2004-12-31 |
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