DK1075462T3 - Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. - Google Patents

Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.

Info

Publication number
DK1075462T3
DK1075462T3 DK99924824T DK99924824T DK1075462T3 DK 1075462 T3 DK1075462 T3 DK 1075462T3 DK 99924824 T DK99924824 T DK 99924824T DK 99924824 T DK99924824 T DK 99924824T DK 1075462 T3 DK1075462 T3 DK 1075462T3
Authority
DK
Denmark
Prior art keywords
hydroxy
triiodo
oxopropyl
amino
benzenedicarboxamide
Prior art date
Application number
DK99924824T
Other languages
Danish (da)
English (en)
Inventor
Nicola Desantis
Salvatore Incandela
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK1075462T3 publication Critical patent/DK1075462T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
DK99924824T 1998-05-08 1999-04-26 Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. DK1075462T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI001005A IT1299202B1 (it) 1998-05-08 1998-05-08 Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
PCT/EP1999/002804 WO1999058494A2 (en) 1998-05-08 1999-04-26 Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide

Publications (1)

Publication Number Publication Date
DK1075462T3 true DK1075462T3 (da) 2003-10-13

Family

ID=11379983

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99924824T DK1075462T3 (da) 1998-05-08 1999-04-26 Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.

Country Status (15)

Country Link
EP (1) EP1075462B1 (zh)
JP (1) JP4390389B2 (zh)
KR (1) KR100612480B1 (zh)
CN (1) CN100336800C (zh)
AT (1) ATE243676T1 (zh)
AU (1) AU749785B2 (zh)
CA (1) CA2331660C (zh)
CZ (1) CZ293801B6 (zh)
DE (1) DE69909078T2 (zh)
DK (1) DK1075462T3 (zh)
ES (1) ES2201719T3 (zh)
IT (1) IT1299202B1 (zh)
NO (1) NO326203B1 (zh)
PT (1) PT1075462E (zh)
WO (1) WO1999058494A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2365963B1 (en) 2008-11-18 2017-06-28 Bracco Imaging S.p.A Process for the preparation of iodinated contrast agent
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
DK2931696T3 (en) 2012-12-11 2018-12-17 Bracco Imaging Spa CONTINUOUS PROCEDURE FOR THE PREPARATION OF (S) -2-ACETYLOXYPROPIONIC ACID
AU2014345727B2 (en) 2013-11-05 2018-07-05 Bracco Imaging Spa Process for the preparation of Iopamidol
CA2949433C (en) 2014-06-10 2022-05-03 Bracco Imaging Spa Method for the preparation of (s)-2-acetyloxypropionic acid and derivatives thereof
CN105272899B (zh) * 2015-11-17 2017-09-22 浙江海洲制药有限公司 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
EP3548461B1 (en) * 2016-12-05 2021-02-03 Bracco Imaging SpA Mechanochemical synthesis of radiographic agents intermediates
CN110687226B (zh) * 2019-10-18 2022-10-25 上海明捷医药科技有限公司 一种测定碘帕醇中2-氯丙酸含量的方法
WO2023117667A1 (en) 2021-12-20 2023-06-29 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodoisophthalic bisamides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (zh) * 1974-12-13 1978-12-29 Savac Ag
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio

Also Published As

Publication number Publication date
DE69909078D1 (de) 2003-07-31
CN100336800C (zh) 2007-09-12
KR20010071221A (ko) 2001-07-28
NO20005616D0 (no) 2000-11-07
PT1075462E (pt) 2003-10-31
ITMI981005A1 (it) 1999-11-08
EP1075462B1 (en) 2003-06-25
ATE243676T1 (de) 2003-07-15
WO1999058494A2 (en) 1999-11-18
AU4135699A (en) 1999-11-29
CZ293801B6 (cs) 2004-08-18
WO1999058494A3 (en) 2000-01-20
JP2002517381A (ja) 2002-06-18
EP1075462A2 (en) 2001-02-14
AU749785B2 (en) 2002-07-04
IT1299202B1 (it) 2000-02-29
CA2331660A1 (en) 1999-11-18
ES2201719T3 (es) 2004-03-16
KR100612480B1 (ko) 2006-08-16
JP4390389B2 (ja) 2009-12-24
NO326203B1 (no) 2008-10-20
CA2331660C (en) 2008-07-08
NO20005616L (no) 2000-11-07
CN1302288A (zh) 2001-07-04
DE69909078T2 (de) 2003-12-18
CZ20004124A3 (cs) 2002-03-13

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