DK1063228T5 - Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents

Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Info

Publication number
DK1063228T5
DK1063228T5 DK99907879T DK99907879T DK1063228T5 DK 1063228 T5 DK1063228 T5 DK 1063228T5 DK 99907879 T DK99907879 T DK 99907879T DK 99907879 T DK99907879 T DK 99907879T DK 1063228 T5 DK1063228 T5 DK 1063228T5
Authority
DK
Denmark
Prior art keywords
substituents
hydrocarbon group
group optionally
aliphatic hydrocarbon
hydrogen atom
Prior art date
Application number
DK99907879T
Other languages
Danish (da)
English (en)
Other versions
DK1063228T3 (da
Inventor
Yuzo Ichimori
Masayuki Ii
Katsumi Itoh
Tomoyuki Kitazaki
Junji Yamada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of DK1063228T3 publication Critical patent/DK1063228T3/da
Application granted granted Critical
Publication of DK1063228T5 publication Critical patent/DK1063228T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Silicon Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK99907879T 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf DK1063228T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5649298 1998-03-09
JP28436298 1998-10-06
PCT/JP1999/001103 WO1999046242A1 (fr) 1998-03-09 1999-03-08 Derives de cycloalcene, leur procede de fabrication et d'utilisation

Publications (2)

Publication Number Publication Date
DK1063228T3 DK1063228T3 (da) 2005-04-25
DK1063228T5 true DK1063228T5 (da) 2009-06-15

Family

ID=26397446

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99907879T DK1063228T5 (da) 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Country Status (20)

Country Link
US (1) US6495604B1 (ko)
EP (2) EP1524263A1 (ko)
JP (2) JP3665712B2 (ko)
KR (4) KR100492098B1 (ko)
CN (1) CN100432049C (ko)
AT (1) ATE287393T1 (ko)
AU (1) AU747521B2 (ko)
BR (1) BR9908610A (ko)
CA (1) CA2320467C (ko)
DE (1) DE69923300T2 (ko)
DK (1) DK1063228T5 (ko)
ES (1) ES2232114T3 (ko)
HK (1) HK1031723A1 (ko)
HU (1) HU230061B1 (ko)
ID (1) ID25649A (ko)
NO (1) NO326426B1 (ko)
NZ (1) NZ505874A (ko)
PT (1) PT1063228E (ko)
RU (1) RU2214398C2 (ko)
WO (1) WO1999046242A1 (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9908610A (pt) 1998-03-09 2000-12-05 Takeda Chemical Industries Ltd Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto, processos par ainibir a produção de óxido nìtrico e/ou citocina em mamìferos, e para impedir ou tratar doença cardìaca, doença autoimune ou choque séptico em mamìferos, e, pró medicamentos
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
DE60045033D1 (de) 1999-08-06 2010-11-11 Takeda Pharmaceutical Substituierte aromatische ringverbindungen, verfahren zu ihrer herstellung und ihre anwendung
WO2001040498A1 (fr) * 1999-11-29 2001-06-07 Takeda Chemical Industries, Ltd. Procede de production de derives optiquement actifs du cyclohexene et de leurs intermediaires
JP4863553B2 (ja) * 2000-02-04 2012-01-25 武田薬品工業株式会社 安定な乳化組成物
CA2400804C (en) 2000-02-04 2009-09-01 Takeda Chemical Industries, Ltd. Stable emulsion compositions of cycloalkene derivatives
JP4922507B2 (ja) * 2000-08-10 2012-04-25 武田薬品工業株式会社 医薬組成物
US6951885B2 (en) 2000-08-10 2005-10-04 Takeda Pharmaceutical Company Limited Pharmaceutical composition
DE60144570D1 (de) 2000-10-18 2011-06-16 Takeda Pharmaceutical Verfahren zur herstellung von optisch aktiven sulfonamiden und zwischenprodukte zur deren synthese
US20040063685A1 (en) * 2000-12-08 2004-04-01 Juji Ilzawa Combination Drugs
US7579325B2 (en) 2001-03-21 2009-08-25 Eisai R & D Management Co., Ltd. Drugs containing reduced of vitamin B2
JP5137289B2 (ja) * 2001-08-03 2013-02-06 武田薬品工業株式会社 安定な乳化組成物
EP2366389A1 (en) * 2002-04-08 2011-09-21 Takeda Pharmaceutical Company Limited Severe sepsis preventive therapeutic agent
EP1692116B1 (en) 2003-12-03 2011-03-09 Boehringer Ingelheim Pharmaceuticals Inc. 1,2,3-triazole amide derivatives as inhibitors of cytokine production
TWI462745B (zh) * 2005-04-28 2014-12-01 Takeda Pharmaceutical 安定的乳化組成物
NZ567269A (en) 2005-09-14 2010-06-25 Daiichi Sankyo Co Ltd Cycloalkene derivatives for supressing the effects of endotoxins
EP1997902B1 (en) 2006-03-30 2013-09-18 Hiroshima University Screening method
JPWO2007123186A1 (ja) 2006-04-20 2009-09-03 武田薬品工業株式会社 医薬
EP2018855A1 (en) * 2006-05-15 2009-01-28 Takeda Pharmaceutical Company Limited Pharmaceutical agent
WO2008004673A1 (fr) 2006-07-07 2008-01-10 Takeda Pharmaceutical Company Limited Dérives de cycloalkène, procédé de production des dérivés et utilisation de ceux-ci
JP2008260760A (ja) * 2007-03-12 2008-10-30 Daiichi Sankyo Co Ltd 置換シクロアルケン誘導体を含有する医薬組成物
WO2011093512A1 (en) 2010-01-27 2011-08-04 Takeda Pharmaceutical Company Limited Compounds for suppressing a peripheral nerve disorder induced by an anti - cancer agent
WO2012039447A1 (ja) 2010-09-24 2012-03-29 第一三共株式会社 置換シクロアルケン誘導体の結晶
CA2915793A1 (en) * 2012-07-03 2014-01-09 Jay Pravda Methods for treating, diagnosing and/or monitoring progression of oxo associated states
US9364438B2 (en) 2012-09-26 2016-06-14 Takeda Pharmaceutical Company Limited Process for producing solid particles
EA033083B1 (ru) 2015-05-08 2019-08-30 Такеда Фармасьютикал Компани Лимитед Циклические соединения
CA3036349A1 (en) 2016-09-09 2018-03-15 Takeda Pharmaceutical Company Limited Cyclic compound having toll-like receptor 4 (tlr4) inhibitory activity
WO2018156297A1 (en) * 2017-02-24 2018-08-30 Taiwanj Pharmaceuticals Co., Ltd Sulfonamide or amide compounds, compositions and methods for the prophylaxis and/or treatment of autoimmune, inflammation or infection related disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007552A1 (en) 1990-11-06 1992-05-14 Nippon Shinyaku Co., Ltd. Lyophilized preparation and production thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
EP0746318A1 (en) 1994-02-25 1996-12-11 Takeda Chemical Industries, Ltd. Injectable emulsions containing antifungal triazole derivatives
JPH08109165A (ja) * 1994-08-18 1996-04-30 Chugai Pharmaceut Co Ltd 一酸化窒素合成酵素阻害作用を有するアミノ酸誘導体
EP0776886A4 (en) * 1994-08-18 1999-05-12 Chugai Pharmaceutical Co Ltd AMINO ACID DERIVATIVE WITH NITROGEN MONOXIDE SYNTHETASE INHIBITING ACTIVITY
BR9908610A (pt) 1998-03-09 2000-12-05 Takeda Chemical Industries Ltd Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto, processos par ainibir a produção de óxido nìtrico e/ou citocina em mamìferos, e para impedir ou tratar doença cardìaca, doença autoimune ou choque séptico em mamìferos, e, pró medicamentos
CA2400804C (en) 2000-02-04 2009-09-01 Takeda Chemical Industries, Ltd. Stable emulsion compositions of cycloalkene derivatives

Also Published As

Publication number Publication date
JP4342453B2 (ja) 2009-10-14
NO20004485D0 (no) 2000-09-08
KR20050071719A (ko) 2005-07-07
EP1063228B1 (en) 2005-01-19
RU2214398C2 (ru) 2003-10-20
CA2320467C (en) 2010-05-04
CN100432049C (zh) 2008-11-12
WO1999046242A1 (fr) 1999-09-16
JP3665712B2 (ja) 2005-06-29
NZ505874A (en) 2003-09-26
EP1063228A1 (en) 2000-12-27
NO326426B1 (no) 2008-12-01
ES2232114T3 (es) 2005-05-16
NO20004485L (no) 2000-09-08
JP2000178246A (ja) 2000-06-27
EP1063228A4 (en) 2001-08-08
DE69923300T2 (de) 2006-01-05
KR100577044B1 (ko) 2006-05-08
CA2320467A1 (en) 1999-09-16
HUP0101192A3 (en) 2003-09-29
AU2746499A (en) 1999-09-27
JP2005232168A (ja) 2005-09-02
HK1031723A1 (en) 2001-06-22
DE69923300D1 (de) 2005-02-24
ID25649A (id) 2000-10-19
HUP0101192A2 (hu) 2001-08-28
EP1524263A1 (en) 2005-04-20
AU747521C (en) 1999-09-27
DK1063228T3 (da) 2005-04-25
AU747521B2 (en) 2002-05-16
KR20050026075A (ko) 2005-03-14
PT1063228E (pt) 2005-05-31
KR100779889B1 (ko) 2007-11-28
PL342826A1 (en) 2001-07-02
KR20060017921A (ko) 2006-02-27
KR20010034555A (ko) 2001-04-25
US6495604B1 (en) 2002-12-17
BR9908610A (pt) 2000-12-05
ATE287393T1 (de) 2005-02-15
HU230061B1 (hu) 2015-06-29
CN1291184A (zh) 2001-04-11
KR100492098B1 (ko) 2005-06-01

Similar Documents

Publication Publication Date Title
DK1063228T3 (da) Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf
NO992549D0 (no) Sukkerforbindelse, geleringsmiddel og fremgangsmÕte for fremstilling derav
FI104172B1 (fi) Herbisidiset 4-bentsoyyli-isoksatsolijohdannaiset
ATE513821T1 (de) Thiadiazolin-derivate zur behandlung von krebs
ID24846A (id) Turunan-turunan bifenilamidina
DE69814800T2 (de) Epoxysuccinamid-derivate oder ihre salze
DE69623497T2 (de) 1-methylcarbapenem-derivate
ATE239741T1 (de) Derivate der phosphonsäure zur inhibierung von carboxypeptidase b
DE69425970D1 (de) Benzol-derivate, verwendbar für ischämische erkrankungen
DK0556813T3 (da) Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler
DK360388A (da) Laegemiddel til behandling af hjerteinsufficiens
DE69828087D1 (de) Aminderivate
ATE189813T1 (de) Prostaglandin-i-analoga
ATE103490T1 (de) Derivate der p-guanidinobenzoesaeure zur behandlung der zerebrovaskulaeren kontraktion.