DK1053304T3 - Krystallinsk TNF-alfa-konverterende enzym og anvendelser heraf - Google Patents

Krystallinsk TNF-alfa-konverterende enzym og anvendelser heraf

Info

Publication number
DK1053304T3
DK1053304T3 DK99905615T DK99905615T DK1053304T3 DK 1053304 T3 DK1053304 T3 DK 1053304T3 DK 99905615 T DK99905615 T DK 99905615T DK 99905615 T DK99905615 T DK 99905615T DK 1053304 T3 DK1053304 T3 DK 1053304T3
Authority
DK
Denmark
Prior art keywords
crystalline
applications
converting enzyme
tnf alpha
alpha converting
Prior art date
Application number
DK99905615T
Other languages
English (en)
Inventor
Roy A Black
Raymond James Paxton
Wolfram Bode
Klaus Maskos
Carlos Fernandez-Catalan
James Ming Chen
Jeremy Ian Levin
Original Assignee
Immunex Corp
Max Planck Inst For Biochemist
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp, Max Planck Inst For Biochemist, Wyeth Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DK1053304T3 publication Critical patent/DK1053304T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
DK99905615T 1998-02-04 1999-02-03 Krystallinsk TNF-alfa-konverterende enzym og anvendelser heraf DK1053304T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7370998P 1998-02-04 1998-02-04
US5008398A 1998-03-30 1998-03-30
US11747699P 1999-01-27 1999-01-27
PCT/US1999/002185 WO1999040182A2 (en) 1998-02-04 1999-02-03 CRYSTALLINE TNF-α-CONVERTING ENZYME AND USES THEREOF

Publications (1)

Publication Number Publication Date
DK1053304T3 true DK1053304T3 (da) 2007-11-05

Family

ID=27367666

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99905615T DK1053304T3 (da) 1998-02-04 1999-02-03 Krystallinsk TNF-alfa-konverterende enzym og anvendelser heraf

Country Status (15)

Country Link
EP (1) EP1053304B1 (da)
JP (1) JP2004503202A (da)
CN (1) CN1342200A (da)
AR (2) AR015513A1 (da)
AT (1) ATE366303T1 (da)
AU (1) AU2574099A (da)
CA (1) CA2319040A1 (da)
DE (1) DE69936445T2 (da)
DK (1) DK1053304T3 (da)
ES (1) ES2293718T3 (da)
HU (1) HUP0101596A1 (da)
IL (3) IL163513A0 (da)
NO (1) NO20003687L (da)
NZ (1) NZ505959A (da)
WO (1) WO1999040182A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406901B1 (en) 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
WO2002033118A2 (en) * 2000-08-03 2002-04-25 The Texas A & M University System Isocitrate lyase enzyme from mycobacterium tuberculosis and inhibitory agents to combat persistent infection
US7138264B1 (en) 2002-05-24 2006-11-21 Schering Corporation Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof
WO2005073400A2 (en) * 2004-01-26 2005-08-11 University Of Massachusetts Method of identifying amp- activated protein kinase (ampk) modulators and uses therefor
TWI516274B (zh) * 2013-11-27 2016-01-11 財團法人工業技術研究院 應用於生髮之方法及醫藥組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
US5702935A (en) * 1994-04-28 1997-12-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method and compounds for inhibiting lipid biosynthesis of bacteria and plants
ATE274346T1 (de) * 1995-06-08 2004-09-15 Immunex Corp Tnf-alpha konvertierendes enzym
KR19990063585A (ko) * 1995-08-30 1999-07-26 데이비드 엘. 버스테인 결정상 ｚａｐ계 단백질
WO1997015588A1 (en) * 1995-10-26 1997-05-01 St. Jude Children's Research Hospital Protective protein/cathepsin a and precursor: crystallization, x-ray diffraction, three-dimensional structure determination and rational drug design
CA2249985A1 (en) * 1996-03-26 1997-10-02 Glaxo Group Limited Tumour necrosis factor alpha convertase

Also Published As

Publication number Publication date
CA2319040A1 (en) 1999-08-12
IL163513A0 (en) 2005-12-18
HUP0101596A1 (hu) 2001-08-28
DE69936445D1 (de) 2007-08-16
AU2574099A (en) 1999-08-23
AR024804A1 (es) 2002-10-23
JP2004503202A (ja) 2004-02-05
AR015513A1 (es) 2001-05-02
DE69936445T2 (de) 2008-04-10
WO1999040182A3 (en) 1999-10-07
IL137557A0 (en) 2001-07-24
NZ505959A (en) 2003-05-30
ATE366303T1 (de) 2007-07-15
IL163513A (en) 2007-03-08
NO20003687L (no) 2000-09-19
ES2293718T3 (es) 2008-03-16
EP1053304A2 (en) 2000-11-22
CN1342200A (zh) 2002-03-27
WO1999040182A2 (en) 1999-08-12
NO20003687D0 (no) 2000-07-18
EP1053304B1 (en) 2007-07-04

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