DK1047445T3 - Modificerede enzymer og anvendelse heraf til peptidsyntese - Google Patents
Modificerede enzymer og anvendelse heraf til peptidsynteseInfo
- Publication number
- DK1047445T3 DK1047445T3 DK99903318.6T DK99903318T DK1047445T3 DK 1047445 T3 DK1047445 T3 DK 1047445T3 DK 99903318 T DK99903318 T DK 99903318T DK 1047445 T3 DK1047445 T3 DK 1047445T3
- Authority
- DK
- Denmark
- Prior art keywords
- application
- peptide synthesis
- modified enzymes
- enzymes
- modified
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7235198P | 1998-01-23 | 1998-01-23 | |
US7226598P | 1998-01-23 | 1998-01-23 | |
PCT/US1999/001413 WO1999037324A1 (en) | 1998-01-23 | 1999-01-21 | Modified enzymes and their use for peptide synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1047445T3 true DK1047445T3 (da) | 2013-11-11 |
Family
ID=26753173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99903318.6T DK1047445T3 (da) | 1998-01-23 | 1999-01-21 | Modificerede enzymer og anvendelse heraf til peptidsyntese |
Country Status (9)
Country | Link |
---|---|
US (2) | US6395532B1 (da) |
EP (1) | EP1047445B1 (da) |
JP (2) | JP2002500874A (da) |
KR (1) | KR20010040397A (da) |
AU (1) | AU739432C (da) |
CA (1) | CA2321169C (da) |
DK (1) | DK1047445T3 (da) |
NZ (1) | NZ506346A (da) |
WO (1) | WO1999037324A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9909130A (pt) | 1998-03-26 | 2000-12-19 | Procter & Gamble | Variantes de protease de serina tendo substituições de amino-ácido |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
AU749383B2 (en) | 1998-07-02 | 2002-06-27 | Genencor International, Inc. | Chemically modified proteins with a carbohydrate moiety |
JP4932990B2 (ja) * | 1998-11-10 | 2012-05-16 | ダニスコ・ユーエス・インコーポレイテッド | 化学修飾突然変異体セリンヒドロラーゼは改良された触媒活性およびキラル選択性を示す |
KR20020057797A (ko) * | 1999-04-28 | 2002-07-12 | 더 거버닝 카운실 오브 더 유니버시티 오브 토론토 | 특이적으로 표적화된 촉매적 안타고니스트 및 그 용도 |
US6627744B2 (en) | 1999-07-02 | 2003-09-30 | Genencor International, Inc. | Synthesis of glycodendrimer reagents |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
CN1373802A (zh) | 1999-07-22 | 2002-10-09 | 宝洁公司 | 在特定表位区域具有氨基酸缺失和取代的枯草杆菌蛋白酶变体 |
EP1210415A2 (en) | 1999-07-22 | 2002-06-05 | The Procter & Gamble Company | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
KR20020021396A (ko) * | 1999-07-22 | 2002-03-20 | 데이비드 엠 모이어 | 입체적으로 보호된 에피토프 영역을 갖는 프로테아제콘쥬게이트 |
CZ2002171A3 (cs) | 1999-07-22 | 2002-06-12 | The Procter & Gamble Company | Proteinázový konjugát, čistící prostředek a prostředek osobní péče |
EP1569953B1 (en) * | 2002-11-25 | 2010-09-29 | Zealand Pharma A/S | Peptide gap junction modulators |
US7087438B2 (en) * | 2004-07-26 | 2006-08-08 | Infineon Technologies Ag | Encapsulation of conductive lines of semiconductor devices |
CN103052704A (zh) | 2010-07-22 | 2013-04-17 | 荷兰联合利华有限公司 | 用于提高清洁的鼠李糖脂和酶的组合物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58144105A (ja) * | 1982-02-12 | 1983-08-27 | Kurabo Ind Ltd | スケ−ル除去獣毛繊維の製法 |
US5244791A (en) | 1984-05-29 | 1993-09-14 | Genecor International, Inc. | Methods of ester hydrolysis |
US5155033A (en) | 1989-01-06 | 1992-10-13 | Genencor, Inc. | Subtilisins modified at position 225 resulting in a shift in catalytic activity |
US5037741A (en) * | 1986-08-18 | 1991-08-06 | The Coca Cola Company | Enzymatic method for the synthesis and separation of peptides |
PT89702B (pt) | 1988-02-11 | 1994-04-29 | Gist Brocades Nv | Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem |
DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
WO1992002615A1 (en) * | 1990-08-09 | 1992-02-20 | Genentech, Inc. | Serine protease variants having peptide ligase activity |
US5629173A (en) * | 1990-08-09 | 1997-05-13 | Genentech, Inc. | Methods of use of serine protease variants having peptide ligase activity |
US5316935A (en) | 1992-04-06 | 1994-05-31 | California Institute Of Technology | Subtilisin variants suitable for hydrolysis and synthesis in organic media |
GB9416841D0 (en) * | 1994-08-19 | 1994-10-12 | Finnfeeds Int Ltd | An enzyme feed additive and animal feed including it |
US5837516A (en) | 1995-03-03 | 1998-11-17 | Genentech, Inc. | Subtilisin variants capable of cleaving substrates containing basic residues |
-
1999
- 1999-01-21 KR KR1020007008073A patent/KR20010040397A/ko not_active Application Discontinuation
- 1999-01-21 DK DK99903318.6T patent/DK1047445T3/da active
- 1999-01-21 US US09/234,957 patent/US6395532B1/en not_active Expired - Lifetime
- 1999-01-21 CA CA2321169A patent/CA2321169C/en not_active Expired - Fee Related
- 1999-01-21 AU AU23371/99A patent/AU739432C/en not_active Ceased
- 1999-01-21 NZ NZ506346A patent/NZ506346A/xx not_active IP Right Cessation
- 1999-01-21 WO PCT/US1999/001413 patent/WO1999037324A1/en not_active Application Discontinuation
- 1999-01-21 JP JP2000528304A patent/JP2002500874A/ja active Pending
- 1999-01-21 EP EP99903318.6A patent/EP1047445B1/en not_active Expired - Lifetime
-
2002
- 2002-02-13 US US10/075,895 patent/US6576454B2/en not_active Expired - Lifetime
-
2009
- 2009-09-14 JP JP2009211777A patent/JP2010029195A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1999037324A1 (en) | 1999-07-29 |
US6576454B2 (en) | 2003-06-10 |
AU2337199A (en) | 1999-08-09 |
AU739432C (en) | 2002-05-16 |
US6395532B1 (en) | 2002-05-28 |
JP2010029195A (ja) | 2010-02-12 |
CA2321169C (en) | 2011-08-02 |
AU739432B2 (en) | 2001-10-11 |
US20020137177A1 (en) | 2002-09-26 |
NZ506346A (en) | 2003-06-30 |
JP2002500874A (ja) | 2002-01-15 |
EP1047445B1 (en) | 2013-08-28 |
KR20010040397A (ko) | 2001-05-15 |
EP1047445A4 (en) | 2001-09-12 |
CA2321169A1 (en) | 1999-07-29 |
EP1047445A1 (en) | 2000-11-02 |
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