AR015513A1 - Metodo para identificar un compuesto que se asocia con la enzima conversora de alfa-tnf - Google Patents
Metodo para identificar un compuesto que se asocia con la enzima conversora de alfa-tnfInfo
- Publication number
- AR015513A1 AR015513A1 ARP990100476A ARP990100476A AR015513A1 AR 015513 A1 AR015513 A1 AR 015513A1 AR P990100476 A ARP990100476 A AR P990100476A AR P990100476 A ARP990100476 A AR P990100476A AR 015513 A1 AR015513 A1 AR 015513A1
- Authority
- AR
- Argentina
- Prior art keywords
- tace
- compound
- polypeptide
- identifying
- tnf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se revela un método para identificar un compuesto que se asocia con la enzima conversora de alfa-TNF (TACE). Un polipéptido de la enzima conversora dealfa-TNF se produce en forma cristalina en una unica composicion. El polipéptido preferentemente comprende el dominio catalítico de la TACE. También puedecomprender los dominios pro y catalíticos de la TACE. El polipéptido puede ser codificado por los residuos de aminoácidos 1-477 de la TACE, puede tambiénincluir cambios simples de aminoácidos y secuencias fusionadas adicionales de Gly-Ser(His)6 en el C terminal. Un socio en la union durante la co-cristalizacioncon el polipéptido de TACE puede incluirse en la composicion. El Cristal en la composicion tiene preferentemente una estructura cristalina que difracta a 2.0Angstrom. Las coordenadas de difraccion por rayos X de la estructura cristalina también se revelan. El compuesto se designa de acuerdo a estas coordenadas demanera que forme un enlace con TACE. El compuesto es subsecuentementesintetizado y se determina su capacidad de asociacion con TACE.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7370998P | 1998-02-04 | 1998-02-04 | |
| US5008398A | 1998-03-30 | 1998-03-30 | |
| US11747699P | 1999-01-27 | 1999-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015513A1 true AR015513A1 (es) | 2001-05-02 |
Family
ID=27367666
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100476A AR015513A1 (es) | 1998-02-04 | 1999-02-04 | Metodo para identificar un compuesto que se asocia con la enzima conversora de alfa-tnf |
| ARP000103727A AR024804A1 (es) | 1998-02-04 | 2000-07-19 | Un medio de lectura en computadora que tiene grabado datos de coordenadas cristalograficas de rx de una enzima conversora de a-tnf. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103727A AR024804A1 (es) | 1998-02-04 | 2000-07-19 | Un medio de lectura en computadora que tiene grabado datos de coordenadas cristalograficas de rx de una enzima conversora de a-tnf. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1053304B1 (es) |
| JP (1) | JP2004503202A (es) |
| CN (1) | CN1342200A (es) |
| AR (2) | AR015513A1 (es) |
| AT (1) | ATE366303T1 (es) |
| AU (1) | AU2574099A (es) |
| CA (1) | CA2319040A1 (es) |
| DE (1) | DE69936445T2 (es) |
| DK (1) | DK1053304T3 (es) |
| ES (1) | ES2293718T3 (es) |
| HU (1) | HUP0101596A1 (es) |
| IL (3) | IL137557A0 (es) |
| NO (1) | NO20003687L (es) |
| NZ (1) | NZ505959A (es) |
| WO (1) | WO1999040182A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406901B1 (en) | 1995-06-08 | 2002-06-18 | Immunex Corporation | TNF-a converting enzyme |
| US20030018166A1 (en) * | 2000-08-03 | 2003-01-23 | Sacchettini James C. | Structure of isocitrate lyase enzyme from mycobacterium tuberculosis and inhibitory agents to combat persistent infection |
| US7138264B1 (en) | 2002-05-24 | 2006-11-21 | Schering Corporation | Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof |
| US20060035301A1 (en) * | 2004-01-26 | 2006-02-16 | University Of Massachusetts | Method of identifying protein kinase modulators and uses therefore |
| CN104667257B (zh) * | 2013-11-27 | 2017-09-12 | 财团法人工业技术研究院 | 应用生发胜肽的方法及医药组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5594106A (en) * | 1993-08-23 | 1997-01-14 | Immunex Corporation | Inhibitors of TNF-α secretion |
| US5702935A (en) * | 1994-04-28 | 1997-12-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method and compounds for inhibiting lipid biosynthesis of bacteria and plants |
| DK0830130T3 (da) * | 1995-06-08 | 2004-12-20 | Immunex Corp | TNF-alfa-omdannende enzym |
| CA2226963A1 (en) * | 1995-08-30 | 1997-03-06 | Xiaode Lu | Crystalline zap family proteins |
| WO1997015588A1 (en) * | 1995-10-26 | 1997-05-01 | St. Jude Children's Research Hospital | Protective protein/cathepsin a and precursor: crystallization, x-ray diffraction, three-dimensional structure determination and rational drug design |
| CA2249985A1 (en) * | 1996-03-26 | 1997-10-02 | Glaxo Group Limited | Tumour necrosis factor alpha convertase |
-
1999
- 1999-02-03 HU HU0101596A patent/HUP0101596A1/hu unknown
- 1999-02-03 EP EP99905615A patent/EP1053304B1/en not_active Expired - Lifetime
- 1999-02-03 JP JP2000530596A patent/JP2004503202A/ja active Pending
- 1999-02-03 DK DK99905615T patent/DK1053304T3/da active
- 1999-02-03 CN CN99804893.3A patent/CN1342200A/zh active Pending
- 1999-02-03 AT AT99905615T patent/ATE366303T1/de not_active IP Right Cessation
- 1999-02-03 AU AU25740/99A patent/AU2574099A/en not_active Abandoned
- 1999-02-03 NZ NZ505959A patent/NZ505959A/en unknown
- 1999-02-03 DE DE69936445T patent/DE69936445T2/de not_active Expired - Fee Related
- 1999-02-03 WO PCT/US1999/002185 patent/WO1999040182A2/en active IP Right Grant
- 1999-02-03 ES ES99905615T patent/ES2293718T3/es not_active Expired - Lifetime
- 1999-02-03 IL IL13755799A patent/IL137557A0/xx not_active IP Right Cessation
- 1999-02-03 CA CA002319040A patent/CA2319040A1/en not_active Abandoned
- 1999-02-03 IL IL16351399A patent/IL163513A0/xx active IP Right Grant
- 1999-02-04 AR ARP990100476A patent/AR015513A1/es not_active Application Discontinuation
-
2000
- 2000-07-18 NO NO20003687A patent/NO20003687L/no not_active Application Discontinuation
- 2000-07-19 AR ARP000103727A patent/AR024804A1/es unknown
-
2004
- 2004-08-12 IL IL163513A patent/IL163513A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004503202A (ja) | 2004-02-05 |
| IL163513A0 (en) | 2005-12-18 |
| NO20003687D0 (no) | 2000-07-18 |
| HUP0101596A1 (hu) | 2001-08-28 |
| AU2574099A (en) | 1999-08-23 |
| CN1342200A (zh) | 2002-03-27 |
| ES2293718T3 (es) | 2008-03-16 |
| DE69936445T2 (de) | 2008-04-10 |
| AR024804A1 (es) | 2002-10-23 |
| DE69936445D1 (de) | 2007-08-16 |
| ATE366303T1 (de) | 2007-07-15 |
| EP1053304A2 (en) | 2000-11-22 |
| EP1053304B1 (en) | 2007-07-04 |
| IL137557A0 (en) | 2001-07-24 |
| CA2319040A1 (en) | 1999-08-12 |
| DK1053304T3 (da) | 2007-11-05 |
| IL163513A (en) | 2007-03-08 |
| NZ505959A (en) | 2003-05-30 |
| WO1999040182A2 (en) | 1999-08-12 |
| NO20003687L (no) | 2000-09-19 |
| WO1999040182A3 (en) | 1999-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE44533T1 (de) | Hemmen von enzymen. | |
| AR053946A2 (es) | Variante de alfa-amilasa de bacillus stearothermophilus original | |
| BR9407047A (pt) | Processo para separaçao de uma proteina de uma soluçao aquosa de proteinas | |
| CY1112833T1 (el) | Καινοφανης προσδετης της κυτοκινης ζcυτοr17 | |
| DE69434817D1 (de) | Protease varianten | |
| DK0502089T4 (da) | Silicasoler, en fremgangsmåde til fremstilling af silicasoler og anvendelse af solerne | |
| ATE342962T1 (de) | Zusammensetzungen und verfahren für verbesserte zellkultur | |
| DK0765343T3 (da) | Monoklonale antistoffer imod CD44v6 | |
| ATE169678T1 (de) | Stabilisierte enzyme | |
| DK39693D0 (da) | Enzym | |
| NO20001668D0 (no) | Anvendelse av et DNA-fragment, samt komplementære kjeder, derivater og deler derav | |
| DE59208300D1 (de) | Verwendung von halogenkohlenwasserstoff-freien reinigungsmitteln zur fluxentfernung von elektronischen und elektrischen baugruppen | |
| AR015513A1 (es) | Metodo para identificar un compuesto que se asocia con la enzima conversora de alfa-tnf | |
| ATE426028T1 (de) | Zellvolumenregulierte humane kinase h-sgk | |
| IL200132A0 (en) | Method for cell adhesion and wound healing | |
| EP0498784A3 (en) | Inhibitors of retroviral protease | |
| DK0458937T3 (da) | Varianter af PAI-2 | |
| NO895002D0 (no) | Enzymhemmende aminosyrederivater. | |
| ATE170631T1 (de) | Verfahren und zusammensetzung zur verminderung der effekte von endogener alkalischer phosphatase | |
| ATE211719T1 (de) | Korrosionsinhibitoren enthaltender injektionszement | |
| ATE374824T1 (de) | Lösliche notch basierte substrate für gamma secretase, methoden, zusammensetzungen und verwendungen davon | |
| DK0876610T3 (da) | Fremgangsmåde og anvendelse af polypeptid i sædcelle-æg-binding til at foröge eller mindske fertilitet | |
| ATE180679T1 (de) | Neue verbesserungen hinsichtlich der radiomarkierung von proteinen | |
| DE59811521D1 (de) | Verfahren zur herstellung einer elektrode für entladungslampen | |
| DE60125386D1 (de) | Verfahren zur Prävention einer durch Gefrieren induzierten Abnahme der Aktivität eines Proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |