DE69936445D1 - Kristallines tnf-alpha-konvertierendes enzym und verwendung davon - Google Patents

Kristallines tnf-alpha-konvertierendes enzym und verwendung davon

Info

Publication number
DE69936445D1
DE69936445D1 DE69936445T DE69936445T DE69936445D1 DE 69936445 D1 DE69936445 D1 DE 69936445D1 DE 69936445 T DE69936445 T DE 69936445T DE 69936445 T DE69936445 T DE 69936445T DE 69936445 D1 DE69936445 D1 DE 69936445D1
Authority
DE
Germany
Prior art keywords
tnf
crystalline
converting enzyme
alpha converting
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69936445T
Other languages
English (en)
Other versions
DE69936445T2 (de
Inventor
Roy A Black
Raymond James Paxton
Wolfram Bode
Klaus Maskos
Carlos Fernandez-Catalan
James Ming Chen
Jeremy Ian Levin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Institut fuer Biochemie
Wyeth LLC
Immunex Corp
Original Assignee
Max Planck Institut fuer Biochemie
Wyeth LLC
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Institut fuer Biochemie, Wyeth LLC, Immunex Corp filed Critical Max Planck Institut fuer Biochemie
Publication of DE69936445D1 publication Critical patent/DE69936445D1/de
Application granted granted Critical
Publication of DE69936445T2 publication Critical patent/DE69936445T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69936445T 1998-02-04 1999-02-03 Kristallines tnf-alpha-konvertierendes enzym und verwendung davon Expired - Fee Related DE69936445T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US7370998P 1998-02-04 1998-02-04
US73709P 1998-02-04
US5008398A 1998-03-30 1998-03-30
US50083 1998-03-30
US11747699P 1999-01-27 1999-01-27
US117476P 1999-01-27
PCT/US1999/002185 WO1999040182A2 (en) 1998-02-04 1999-02-03 CRYSTALLINE TNF-α-CONVERTING ENZYME AND USES THEREOF

Publications (2)

Publication Number Publication Date
DE69936445D1 true DE69936445D1 (de) 2007-08-16
DE69936445T2 DE69936445T2 (de) 2008-04-10

Family

ID=27367666

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936445T Expired - Fee Related DE69936445T2 (de) 1998-02-04 1999-02-03 Kristallines tnf-alpha-konvertierendes enzym und verwendung davon

Country Status (15)

Country Link
EP (1) EP1053304B1 (de)
JP (1) JP2004503202A (de)
CN (1) CN1342200A (de)
AR (2) AR015513A1 (de)
AT (1) ATE366303T1 (de)
AU (1) AU2574099A (de)
CA (1) CA2319040A1 (de)
DE (1) DE69936445T2 (de)
DK (1) DK1053304T3 (de)
ES (1) ES2293718T3 (de)
HU (1) HUP0101596A1 (de)
IL (3) IL137557A0 (de)
NO (1) NO20003687L (de)
NZ (1) NZ505959A (de)
WO (1) WO1999040182A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406901B1 (en) 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
AU2002233916A1 (en) * 2000-08-03 2002-04-29 Albert Einstein College Of Medicine Isocitrate lyase enzyme from mycobacterium tuberculosis and inhibitory agents to combat persistent infection
US7138264B1 (en) * 2002-05-24 2006-11-21 Schering Corporation Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof
WO2005073400A2 (en) * 2004-01-26 2005-08-11 University Of Massachusetts Method of identifying amp- activated protein kinase (ampk) modulators and uses therefor
TWI516274B (zh) * 2013-11-27 2016-01-11 財團法人工業技術研究院 應用於生髮之方法及醫藥組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
US5702935A (en) * 1994-04-28 1997-12-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method and compounds for inhibiting lipid biosynthesis of bacteria and plants
EP0830130B9 (de) * 1995-06-08 2004-12-29 Immunex Corporation Tnf-alpha konvertierendes enzym
AU6960696A (en) * 1995-08-30 1997-03-19 Ariad Pharmaceuticals, Inc. Crystalline zap family proteins
AU1115797A (en) * 1995-10-26 1997-05-15 Alessandra D'azzo Protective protein/cathepsin a and precursor: crystallization, x-ray diffraction, three-dimensional structure determination and rational drug design
CA2249985A1 (en) * 1996-03-26 1997-10-02 Glaxo Group Limited Tumour necrosis factor alpha convertase

Also Published As

Publication number Publication date
NO20003687D0 (no) 2000-07-18
DK1053304T3 (da) 2007-11-05
CA2319040A1 (en) 1999-08-12
ES2293718T3 (es) 2008-03-16
IL163513A0 (en) 2005-12-18
AR015513A1 (es) 2001-05-02
NO20003687L (no) 2000-09-19
EP1053304A2 (de) 2000-11-22
DE69936445T2 (de) 2008-04-10
ATE366303T1 (de) 2007-07-15
AR024804A1 (es) 2002-10-23
JP2004503202A (ja) 2004-02-05
EP1053304B1 (de) 2007-07-04
CN1342200A (zh) 2002-03-27
AU2574099A (en) 1999-08-23
IL163513A (en) 2007-03-08
IL137557A0 (en) 2001-07-24
NZ505959A (en) 2003-05-30
WO1999040182A3 (en) 1999-10-07
HUP0101596A1 (hu) 2001-08-28
WO1999040182A2 (en) 1999-08-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee