DK1043317T3 - Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddel - Google Patents
Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddelInfo
- Publication number
- DK1043317T3 DK1043317T3 DK98951732T DK98951732T DK1043317T3 DK 1043317 T3 DK1043317 T3 DK 1043317T3 DK 98951732 T DK98951732 T DK 98951732T DK 98951732 T DK98951732 T DK 98951732T DK 1043317 T3 DK1043317 T3 DK 1043317T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkoxyl
- active ingredient
- drugs containing
- pyridazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31813297 | 1997-11-19 | ||
JP31813397A JP3999861B2 (ja) | 1997-11-19 | 1997-11-19 | 新規ピリダジン誘導体及びこれを有効成分とする医薬 |
PCT/JP1998/005023 WO1999025697A1 (fr) | 1997-11-19 | 1998-11-09 | Nouveaux derives de pyridazine et medicaments contenant ces composes comme principe actif |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1043317T3 true DK1043317T3 (da) | 2009-07-06 |
Family
ID=26569260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98951732T DK1043317T3 (da) | 1997-11-19 | 1998-11-09 | Pyridazinderivater og medikamenter indeholdende dem som aktiv bestanddel |
Country Status (21)
Country | Link |
---|---|
US (11) | US6348468B1 (da) |
EP (2) | EP2017266A1 (da) |
KR (1) | KR100626605B1 (da) |
CN (1) | CN1142148C (da) |
AT (1) | ATE428700T1 (da) |
AU (1) | AU738595B2 (da) |
BR (1) | BR9813998A (da) |
CA (1) | CA2307111C (da) |
DE (1) | DE69840755D1 (da) |
DK (1) | DK1043317T3 (da) |
ES (1) | ES2324126T3 (da) |
HK (1) | HK1032969A1 (da) |
HU (1) | HUP0100059A3 (da) |
ID (1) | ID24166A (da) |
MX (1) | MXPA00004955A (da) |
NO (1) | NO316021B1 (da) |
NZ (1) | NZ504045A (da) |
PT (1) | PT1043317E (da) |
RU (1) | RU2209813C2 (da) |
TW (1) | TW502025B (da) |
WO (1) | WO1999025697A1 (da) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2017266A1 (en) * | 1997-11-19 | 2009-01-21 | Kowa Co., Ltd. | Pyridazine derivatives and medicines containing the same as effective ingredients |
TW587079B (en) | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
ES2162731B1 (es) * | 1999-06-04 | 2003-02-16 | Faes Fabrica Espanola De Produ | Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas. |
PE20011333A1 (es) | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2 |
US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
AU761191B2 (en) * | 2001-05-24 | 2003-05-29 | Pfizer Products Inc. | Therapies for tissue damage resulting from ischemia |
CN1304379C (zh) * | 2001-09-26 | 2007-03-14 | 兴和株式会社 | 水溶性苯基哒嗪衍生物及含有该衍生物的药物 |
MY128945A (en) * | 2002-04-16 | 2007-03-30 | Kowa Co | Solid dispersion composition |
US7074959B2 (en) * | 2002-08-01 | 2006-07-11 | New Mexico Highlands University | Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces |
WO2004078751A1 (ja) * | 2003-03-07 | 2004-09-16 | Kowa Co., Ltd. | ベンゾフラン誘導体 |
MXPA05009972A (es) | 2003-03-18 | 2005-11-04 | Kowa Co | Derivado de fenilpiridazina soluble en agua y medicina que contiene el mismo. |
MY147403A (en) * | 2003-04-29 | 2012-11-30 | Kowa Co | Composition containing medicine extremely slightly solube in water and method for preparation thereof |
JP4579825B2 (ja) * | 2003-04-29 | 2010-11-10 | 興和株式会社 | 溶出性に優れた超難水溶性薬物含有組成物及びその製造法 |
JPWO2005012259A1 (ja) * | 2003-07-30 | 2007-09-27 | 興和株式会社 | オステオポンチン産生抑制方法 |
EP1604988A1 (en) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
EP1797882A4 (en) * | 2004-09-29 | 2009-11-18 | Kowa Co | PROPHYLACTIC AND / OR THERAPEUTIC DRUGS FOR RHEUMATOID ARTHRITIS |
WO2006104172A1 (ja) * | 2005-03-29 | 2006-10-05 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療薬 |
KR20080038339A (ko) * | 2005-08-31 | 2008-05-06 | 코와 가부시키가이샤 | 관절 류머티즘의 예방 및/또는 치료법 |
WO2007044796A2 (en) * | 2005-10-11 | 2007-04-19 | Nps Pharmaceuticals, Inc. | Pyridazinone compounds as calcilytics |
CN101296707A (zh) * | 2005-10-28 | 2008-10-29 | 兴和株式会社 | 类风湿性关节炎的预防和/或治疗方法 |
DE102005057924A1 (de) * | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
US20090203701A1 (en) * | 2006-06-29 | 2009-08-13 | Kowa Co., Ltd | Prophylactic and/or therapeutic agent for rheumatoid arthritis |
DE102006037478A1 (de) | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
US20100210649A1 (en) * | 2006-12-21 | 2010-08-19 | Sloan-Kettering Institute For Cancer Research | Pyridazinones and furan-containing compounds |
CN101600435A (zh) * | 2007-01-29 | 2009-12-09 | 兴和株式会社 | 多发性硬化症治疗剂 |
US20100120732A1 (en) * | 2007-03-09 | 2010-05-13 | Kowa Co., Ltd. | Agent for prevention and/or treatment of systemic lupus erythematosus |
DE102007025718A1 (de) | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007025717A1 (de) | 2007-06-01 | 2008-12-11 | Merck Patent Gmbh | Arylether-pyridazinonderivate |
DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007038957A1 (de) | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
DE102007041115A1 (de) | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | Thiadiazinonderivate |
DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008062826A1 (de) | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
DE102009004061A1 (de) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | Pyridazinonderivate |
CA2788355C (en) * | 2010-02-18 | 2018-03-06 | Devi Reddy Gohimukkula | Phenyl-heteroaryl derivatives and methods of use thereof |
WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
CN102603676B (zh) * | 2012-02-20 | 2014-02-12 | 徐江平 | 一种能避免呕吐反应的磷酸二酯酶4抑制剂 |
CN109071534B (zh) | 2016-04-15 | 2021-11-23 | 艾伯维公司 | 布罗莫结构域抑制剂 |
AU2017348186A1 (en) * | 2016-10-26 | 2019-05-16 | Proteostasis Therapeutics, Inc | Pyridazine derivatives, compositions and methods for modulating CFTR |
AU2021219788A1 (en) | 2020-02-14 | 2022-09-08 | Fmc Corporation | Substituted 5,6-diphenyl-3(2H)-pyridazinones for use as fungicides |
TW202222163A (zh) * | 2020-08-14 | 2022-06-16 | 瑞士商先正達農作物保護公司 | 化學方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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AR206496A1 (es) | 1972-07-03 | 1976-07-30 | Riker Laboratories Inc | Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas |
EP0088128A4 (en) * | 1981-09-11 | 1984-04-06 | Diamond Shamrock Corp | ANTI-IGNITION AND ANALGETIC 4-PYRIDYLPYRIDAZINE (2H) -3-ONE. |
JPH0753725B2 (ja) | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
JPH01258671A (ja) * | 1987-12-01 | 1989-10-16 | Morishita Pharmaceut Co Ltd | 5−(1h−イミダゾール−1−イル)−3(2h)−ピリダジノン誘導体 |
FI91062C (fi) | 1988-12-28 | 1994-05-10 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi |
WO1991017983A1 (en) * | 1990-05-15 | 1991-11-28 | E.I. Du Pont De Nemours And Company | Arthropodicidal tetrahydropyridazines |
IL104369A0 (en) | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
JPH08311032A (ja) * | 1995-05-18 | 1996-11-26 | Eisai Co Ltd | α,β−不飽和ケトン誘導体 |
EP0871444A4 (en) | 1995-08-10 | 1999-01-13 | Merck & Co Inc | 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF |
ATE271547T1 (de) | 1997-03-14 | 2004-08-15 | Merck Frosst Canada Inc | Pyridazinone als inhibitoren von cyclooxygenase-2 |
BR9812127A (pt) | 1997-08-22 | 2000-07-18 | Abbott Lab | Arilpiridazinonas como inibidores da biossìntese de prostagleina endoperóxido h sintase |
PT1005460E (pt) | 1997-08-22 | 2006-07-31 | Abbott Lab | Biossintese de inibidores de prostaglandina-endoperoxido h-sintase |
EP2017266A1 (en) * | 1997-11-19 | 2009-01-21 | Kowa Co., Ltd. | Pyridazine derivatives and medicines containing the same as effective ingredients |
TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
KR100666838B1 (ko) | 1998-10-27 | 2007-01-11 | 아보트 러보러터리즈 | 프로스타글란딘 엔도퍼옥사이드 h 신타제 생합성 억제제 및 이를 포함하는 약제학적 조성물 |
JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
US6664256B1 (en) * | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
-
1998
- 1998-11-09 EP EP08019558A patent/EP2017266A1/en not_active Withdrawn
- 1998-11-09 MX MXPA00004955A patent/MXPA00004955A/es not_active IP Right Cessation
- 1998-11-09 CA CA002307111A patent/CA2307111C/en not_active Expired - Fee Related
- 1998-11-09 AT AT98951732T patent/ATE428700T1/de not_active IP Right Cessation
- 1998-11-09 EP EP98951732A patent/EP1043317B1/en not_active Expired - Lifetime
- 1998-11-09 PT PT98951732T patent/PT1043317E/pt unknown
- 1998-11-09 US US09/530,949 patent/US6348468B1/en not_active Expired - Fee Related
- 1998-11-09 NZ NZ504045A patent/NZ504045A/en unknown
- 1998-11-09 DK DK98951732T patent/DK1043317T3/da active
- 1998-11-09 WO PCT/JP1998/005023 patent/WO1999025697A1/ja not_active Application Discontinuation
- 1998-11-09 ES ES98951732T patent/ES2324126T3/es not_active Expired - Lifetime
- 1998-11-09 HU HU0100059A patent/HUP0100059A3/hu unknown
- 1998-11-09 ID IDW20000931A patent/ID24166A/id unknown
- 1998-11-09 AU AU97626/98A patent/AU738595B2/en not_active Ceased
- 1998-11-09 CN CNB988113015A patent/CN1142148C/zh not_active Expired - Fee Related
- 1998-11-09 KR KR1020007004967A patent/KR100626605B1/ko not_active IP Right Cessation
- 1998-11-09 RU RU2000115577/04A patent/RU2209813C2/ru not_active IP Right Cessation
- 1998-11-09 BR BR9813998-3A patent/BR9813998A/pt active Search and Examination
- 1998-11-09 DE DE69840755T patent/DE69840755D1/de not_active Expired - Lifetime
- 1998-11-17 TW TW087119032A patent/TW502025B/zh not_active IP Right Cessation
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2000
- 2000-04-27 NO NO20002169A patent/NO316021B1/no not_active IP Right Cessation
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2001
- 2001-05-24 HK HK01103597A patent/HK1032969A1/xx not_active IP Right Cessation
- 2001-11-30 US US09/996,804 patent/US20020123496A1/en not_active Abandoned
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2004
- 2004-01-15 US US10/757,525 patent/US20040147516A1/en not_active Abandoned
- 2004-11-12 US US10/986,350 patent/US20050065155A1/en not_active Abandoned
-
2005
- 2005-08-15 US US11/203,174 patent/US20050267113A1/en not_active Abandoned
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2006
- 2006-03-22 US US11/385,995 patent/US20060160804A1/en not_active Abandoned
- 2006-11-01 US US11/590,811 patent/US20070049595A1/en not_active Abandoned
-
2007
- 2007-04-30 US US11/741,947 patent/US20070208025A1/en not_active Abandoned
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2008
- 2008-01-14 US US12/013,691 patent/US20080119474A1/en not_active Abandoned
- 2008-11-03 US US12/263,816 patent/US20090069332A1/en not_active Abandoned
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2009
- 2009-07-06 US US12/497,797 patent/US20090270399A1/en not_active Abandoned
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