ATE271547T1 - Pyridazinone als inhibitoren von cyclooxygenase-2 - Google Patents

Pyridazinone als inhibitoren von cyclooxygenase-2

Info

Publication number
ATE271547T1
ATE271547T1 AT98910544T AT98910544T ATE271547T1 AT E271547 T1 ATE271547 T1 AT E271547T1 AT 98910544 T AT98910544 T AT 98910544T AT 98910544 T AT98910544 T AT 98910544T AT E271547 T1 ATE271547 T1 AT E271547T1
Authority
AT
Austria
Prior art keywords
cyclooxygenase
formula
pyridazinones
inhibitors
compounds
Prior art date
Application number
AT98910544T
Other languages
English (en)
Inventor
Chun Sing Li
Petpiboon Prasit
Jacques Y Gauthier
Cheuk K Lau
Michel Therien
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9707487.6A external-priority patent/GB9707487D0/en
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE271547T1 publication Critical patent/ATE271547T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98910544T 1997-03-14 1998-03-12 Pyridazinone als inhibitoren von cyclooxygenase-2 ATE271547T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4079197P 1997-03-14 1997-03-14
GBGB9707487.6A GB9707487D0 (en) 1997-04-14 1997-04-14 Pyridazinones as inhibitors of cyclooxygenase-2
PCT/CA1998/000233 WO1998041511A1 (en) 1997-03-14 1998-03-12 Pyridazinones as inhibitors of cyclooxygenase-2

Publications (1)

Publication Number Publication Date
ATE271547T1 true ATE271547T1 (de) 2004-08-15

Family

ID=26311369

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98910544T ATE271547T1 (de) 1997-03-14 1998-03-12 Pyridazinone als inhibitoren von cyclooxygenase-2

Country Status (8)

Country Link
EP (1) EP0975604B1 (de)
JP (1) JP2001514669A (de)
AT (1) ATE271547T1 (de)
AU (1) AU738727B2 (de)
CA (1) CA2283399C (de)
DE (1) DE69825154T2 (de)
ES (1) ES2224366T3 (de)
WO (1) WO1998041511A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) * 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
AU773237B2 (en) * 1997-08-22 2004-05-20 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
SK286972B6 (sk) * 1997-08-22 2009-08-06 Abbott Laboratories Arylpyridazinóny ako inhibítory biosyntézy prostaglandín endoperoxid H syntázy, ich použitie a farmaceutická kompozícia s ich obsahom
PT1043317E (pt) 1997-11-19 2009-05-11 Kowa Co Novos derivados de piridazina e fármacos que os contêm como ingrediente activo
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
SK286806B6 (sk) * 1998-10-27 2009-05-07 Abbott Laboratories Pyridazinónové zlúčeniny ako inhibítory cyklooxygenázy, farmaceutická kompozícia s ich obsahom a ich použitie
US6465509B2 (en) * 2000-06-30 2002-10-15 Merck Frosst Canada & Co. Pyrones as inhibitors of cyclooxygenase-2
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
PT1303265E (pt) 2000-07-20 2007-10-09 Lauras As ''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
WO2003059891A1 (en) * 2002-01-18 2003-07-24 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
JPWO2004083188A1 (ja) 2003-03-18 2006-06-22 興和株式会社 水溶性フェニルピリダジン誘導体及びこれを含有する医薬
EP1534305B9 (de) 2003-05-07 2007-03-07 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
DE10322844A1 (de) * 2003-05-19 2004-12-16 Clariant Gmbh Verfahren zur Herstellung von Pyridin-2-boronsäureestern
WO2005007632A1 (en) * 2003-07-18 2005-01-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
EP1916240A1 (de) * 2006-10-25 2008-04-30 Syngeta Participations AG Neue Pyridazin-Derivate
MX2012001645A (es) 2009-08-07 2012-03-21 Du Pont Piridacinas sustituidas con difenilo como fungicidas.
FR2969606B1 (fr) * 2010-12-22 2013-01-11 Pf Medicament Derives de diarylpyridazinones, leur preparation et leur application en therapeutique humaine
EA034868B1 (ru) * 2013-09-12 2020-03-31 Янссен Байофарма, Инк. Пиридазиноновые соединения и их применение
WO2021186458A1 (en) * 2020-03-19 2021-09-23 Abida 6-oxo-3-phenylpyridazine based cyclooxygenase-2 inhibitors for the treatment of inflammatory diseases
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease
CN113735804B (zh) * 2021-10-08 2023-07-18 浙江大学 一种丁烯内酯类化合物的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983000863A1 (en) * 1981-09-11 1983-03-17 Diamond Shamrock Corp Antiinflammatory and analgetic 4-pyridylpyridazin(2h)-3-ones
JPH02256668A (ja) * 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
AU1269495A (en) * 1994-01-10 1995-08-01 Merck Frosst Canada Inc. Phenyl heterocycles as cox-2 inhibitors
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5686470A (en) * 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
WO1996041645A1 (en) * 1995-06-12 1996-12-27 G.D. Searle & Co. Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
US6136839A (en) * 1995-06-12 2000-10-24 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
SI0912518T1 (en) * 1996-07-18 2003-12-31 Merck Frosst Canada & Co. Substituted pyridines as selective cyclooxygenase-2 inhibitors

Also Published As

Publication number Publication date
DE69825154D1 (de) 2004-08-26
AU738727B2 (en) 2001-09-27
CA2283399A1 (en) 1998-09-24
DE69825154T2 (de) 2005-07-21
JP2001514669A (ja) 2001-09-11
EP0975604A1 (de) 2000-02-02
WO1998041511A1 (en) 1998-09-24
ES2224366T3 (es) 2005-03-01
CA2283399C (en) 2006-02-21
AU6491398A (en) 1998-10-12
EP0975604B1 (de) 2004-07-21

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