DK1042305T3 - Inhibering af p38-kinase ved anvendelse af symmetriske og asymmetriske diphenylurinstoffer - Google Patents
Inhibering af p38-kinase ved anvendelse af symmetriske og asymmetriske diphenylurinstofferInfo
- Publication number
- DK1042305T3 DK1042305T3 DK98964221T DK98964221T DK1042305T3 DK 1042305 T3 DK1042305 T3 DK 1042305T3 DK 98964221 T DK98964221 T DK 98964221T DK 98964221 T DK98964221 T DK 98964221T DK 1042305 T3 DK1042305 T3 DK 1042305T3
- Authority
- DK
- Denmark
- Prior art keywords
- diphenylureas
- kinase
- asymmetric
- symmetric
- inhibition
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US99574997A | 1997-12-22 | 1997-12-22 | |
PCT/US1998/027265 WO1999032463A1 (fr) | 1997-12-22 | 1998-12-22 | INHIBITION DE LA KINASE p38 PAR DES DIPHENYL-UREES SYMETRIQUES ET DISSYMETRIQUES |
Publications (1)
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DK1042305T3 true DK1042305T3 (da) | 2005-09-19 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DK98964221T DK1042305T3 (da) | 1997-12-22 | 1998-12-22 | Inhibering af p38-kinase ved anvendelse af symmetriske og asymmetriske diphenylurinstoffer |
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Country | Link |
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EP (2) | EP1616865A1 (fr) |
JP (1) | JP3887769B2 (fr) |
AT (1) | ATE297383T1 (fr) |
AU (1) | AU1939999A (fr) |
CA (1) | CA2315715C (fr) |
DE (2) | DE69830513T2 (fr) |
DK (1) | DK1042305T3 (fr) |
ES (1) | ES2154252T3 (fr) |
HK (1) | HK1032050A1 (fr) |
IL (3) | IL136737A0 (fr) |
PT (1) | PT1042305E (fr) |
WO (1) | WO1999032463A1 (fr) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
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US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
ES2153809T3 (es) * | 1997-12-22 | 2005-07-16 | Bayer Pharmaceuticals Corporation | Inhibicion de la cinasa raf por uso de difnil-ureas sustituidas simetrica y asimetricamente. |
BR9914638A (pt) * | 1998-10-22 | 2001-07-03 | Neurosearch As | Composto, método para a preparação do mesmo, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio ou doença de um corpo de animal vivo |
US20020065296A1 (en) * | 1999-01-13 | 2002-05-30 | Bayer Corporation | Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors |
DK1690853T3 (da) * | 1999-01-13 | 2010-06-07 | Bayer Healthcare Llc | Omega-carboxyaryl-substituerede diphenylurinstoffer til anvendelse som raf-kinaseinhibitorer |
EP1140840B1 (fr) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf |
AU2004200566B2 (en) * | 1999-01-13 | 2006-08-17 | Bayer Pharmaceuticals Corporation | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1158985B1 (fr) * | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38 |
UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
MXPA01008440A (es) | 1999-02-22 | 2002-04-24 | Boehringer Ingelheim Pharma | Derivados heterociclicos policiclos como agentes anti-inflamatorios.. |
WO2000055152A1 (fr) * | 1999-03-12 | 2000-09-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Composes aromatiques heterocycliques utilises en tant qu'agents anti-inflammatoires |
ATE278674T1 (de) | 1999-03-12 | 2004-10-15 | Boehringer Ingelheim Pharma | Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel |
US6337418B1 (en) * | 1999-04-09 | 2002-01-08 | Eastman Chemical Co. | Preparation of C1-C5 alkyl esters of nitro or thioether substituted aromatic carboxylic acids |
ES2253233T3 (es) | 1999-07-09 | 2006-06-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Procedimiento para sintesis de compuestos de urea heteroaril sustituidos. |
US7030109B2 (en) | 1999-07-19 | 2006-04-18 | Pharmacia & Upjohn Company | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
MY122278A (en) * | 1999-07-19 | 2006-04-29 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
MXPA02004879A (es) | 1999-11-16 | 2002-08-30 | Boehringer Ingelheim Pharma | Derivados de urea como agentes antiinflamatorios. |
AU3003701A (en) * | 1999-11-19 | 2001-05-30 | Axxima Pharmaceuticals Ag | Inhibitors of helicobacter pylori induced gastrointestinal diseases |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
US6849409B2 (en) | 2000-10-16 | 2005-02-01 | Axxima Pharmaceuticals Ag | Cellular kinases involved in Cytomegalovirus infection and their inhibition |
WO2002044156A2 (fr) | 2000-11-29 | 2002-06-06 | Glaxo Group Limited | Composes chimiques |
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- 1998-12-22 WO PCT/US1998/027265 patent/WO1999032463A1/fr active Application Filing
- 1998-12-22 PT PT98964221T patent/PT1042305E/pt unknown
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- 1998-12-22 DK DK98964221T patent/DK1042305T3/da active
- 1998-12-22 DE DE69830513T patent/DE69830513T2/de not_active Expired - Lifetime
- 1998-12-22 DE DE1042305T patent/DE1042305T1/de active Pending
- 1998-12-22 EP EP05012144A patent/EP1616865A1/fr not_active Ceased
- 1998-12-22 EP EP98964221A patent/EP1042305B1/fr not_active Expired - Lifetime
- 1998-12-22 JP JP2000525400A patent/JP3887769B2/ja not_active Expired - Fee Related
- 1998-12-22 AU AU19399/99A patent/AU1939999A/en not_active Abandoned
- 1998-12-22 IL IL13673798A patent/IL136737A0/xx active IP Right Grant
- 1998-12-22 AT AT98964221T patent/ATE297383T1/de active
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CA2315715C (fr) | 2010-06-22 |
PT1042305E (pt) | 2005-10-31 |
DE69830513D1 (de) | 2005-07-14 |
EP1042305A1 (fr) | 2000-10-11 |
DE69830513T2 (de) | 2006-03-16 |
IL136737A (en) | 2006-12-10 |
EP1042305B1 (fr) | 2005-06-08 |
EP1042305A4 (fr) | 2003-05-14 |
WO1999032463A1 (fr) | 1999-07-01 |
EP1616865A1 (fr) | 2006-01-18 |
JP3887769B2 (ja) | 2007-02-28 |
HK1032050A1 (en) | 2001-07-06 |
ATE297383T1 (de) | 2005-06-15 |
ES2154252T1 (es) | 2001-04-01 |
ES2154252T3 (es) | 2005-12-01 |
DE1042305T1 (de) | 2001-04-19 |
AU1939999A (en) | 1999-07-12 |
IL170235A (en) | 2010-04-15 |
IL136737A0 (en) | 2001-06-14 |
CA2315715A1 (fr) | 1999-07-01 |
JP2001526276A (ja) | 2001-12-18 |
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