DK1032370T3 - Porøse hydroxyapatitpartikler som bærere for lægemiddelstoffer - Google Patents

Porøse hydroxyapatitpartikler som bærere for lægemiddelstoffer

Info

Publication number
DK1032370T3
DK1032370T3 DK98957268T DK98957268T DK1032370T3 DK 1032370 T3 DK1032370 T3 DK 1032370T3 DK 98957268 T DK98957268 T DK 98957268T DK 98957268 T DK98957268 T DK 98957268T DK 1032370 T3 DK1032370 T3 DK 1032370T3
Authority
DK
Denmark
Prior art keywords
carriers
drug substances
hydroxyapatite particles
porous hydroxyapatite
porous
Prior art date
Application number
DK98957268T
Other languages
Danish (da)
English (en)
Inventor
Christer Karlsson
Per Johan Lundberg
Adam Rosinski
Malin Soederbom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1032370T3 publication Critical patent/DK1032370T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK98957268T 1997-11-28 1998-11-19 Porøse hydroxyapatitpartikler som bærere for lægemiddelstoffer DK1032370T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704400A SE9704400D0 (sv) 1997-11-28 1997-11-28 Porous inorganic particles as carriers for drug substances
PCT/SE1998/002089 WO1999027912A1 (en) 1997-11-28 1998-11-19 Porous hydroxyapatite particles as carriers for drug substances

Publications (1)

Publication Number Publication Date
DK1032370T3 true DK1032370T3 (da) 2004-03-15

Family

ID=20409177

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98957268T DK1032370T3 (da) 1997-11-28 1998-11-19 Porøse hydroxyapatitpartikler som bærere for lægemiddelstoffer

Country Status (26)

Country Link
US (1) US6558703B1 (es)
EP (1) EP1032370B1 (es)
JP (1) JP2001524513A (es)
KR (1) KR20010032557A (es)
CN (1) CN1280492A (es)
AR (1) AR016683A1 (es)
AT (1) ATE256453T1 (es)
AU (1) AU752044B2 (es)
BR (1) BR9814751A (es)
CA (1) CA2311780A1 (es)
DE (1) DE69820674T2 (es)
DK (1) DK1032370T3 (es)
ES (1) ES2210840T3 (es)
HU (1) HUP0100303A3 (es)
ID (1) ID24700A (es)
IL (1) IL136146A0 (es)
NO (1) NO20002719L (es)
NZ (1) NZ504353A (es)
PL (1) PL340927A1 (es)
PT (1) PT1032370E (es)
RU (1) RU2219907C2 (es)
SE (1) SE9704400D0 (es)
SK (1) SK6602000A3 (es)
TW (1) TW524694B (es)
WO (1) WO1999027912A1 (es)
ZA (1) ZA9810463B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924334D0 (en) * 1999-10-15 1999-12-15 Secr Defence Pharmaceutical products and methods of fabrication therefor
AU2001246883B2 (en) 2000-04-11 2004-08-12 Sankyo Company, Limited Stabilized pharmaceutical compositions containing calcium channel blockers
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
KR101207553B1 (ko) 2005-06-02 2012-12-03 (주)씨앤팜 금속 이중층 수산화물을 포함하는 생체 주사제용 약물 담체
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
JP5027410B2 (ja) * 2005-12-13 2012-09-19 株式会社サンギ ユビキノン含有組成物
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
GB0909460D0 (en) 2009-06-02 2009-07-15 Intrinsiq Materials Global Ltd Mesoporus material
EP2950923B1 (en) 2013-02-01 2022-03-09 W.R. Grace & CO. - CONN. Porous silica gel as a carrier for liquid technologies
JP6441940B2 (ja) 2013-09-20 2018-12-19 ティロッツ・ファルマ・アクチエンゲゼルシャフトＴｉｌｌｏｔｔｓ Ｐｈａｒｍａ Ａｇ 遅延放出製剤処方物
CN104133014B (zh) * 2014-07-16 2015-09-16 广州法尔麦兰药物技术有限公司 一种考察布洛伪麻缓释制剂释放度的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413191D0 (en) 1984-05-23 1984-06-27 Beecham Group Plc Pharmaceutical composition
GB8713263D0 (en) 1987-06-05 1987-07-08 Unilever Plc Spheroidal silica
US5055307A (en) 1988-12-29 1991-10-08 Asahi Kagaku Kogyo Kabushiki Kaisha Slow release drug delivery granules and process for production thereof
US5149523A (en) * 1989-06-20 1992-09-22 Aktiebolaget Hassle Polystyrenesulfonate-drug complex and solid dosage forms thereof
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6096324A (en) * 1995-06-13 2000-08-01 Laboratory Skin Care Methods of delivering materials into the skin, and compositions used therein

Also Published As

Publication number Publication date
JP2001524513A (ja) 2001-12-04
ES2210840T3 (es) 2004-07-01
SE9704400D0 (sv) 1997-11-28
ZA9810463B (en) 1999-05-21
NO20002719L (no) 2000-07-28
AU752044B2 (en) 2002-09-05
US6558703B1 (en) 2003-05-06
RU2219907C2 (ru) 2003-12-27
EP1032370B1 (en) 2003-12-17
ATE256453T1 (de) 2004-01-15
EP1032370A1 (en) 2000-09-06
AR016683A1 (es) 2001-07-25
HUP0100303A3 (en) 2004-03-29
PT1032370E (pt) 2004-05-31
CA2311780A1 (en) 1999-06-10
AU1356399A (en) 1999-06-16
HUP0100303A2 (hu) 2001-08-28
WO1999027912A1 (en) 1999-06-10
DE69820674T2 (de) 2004-09-30
BR9814751A (pt) 2000-10-03
PL340927A1 (en) 2001-03-12
CN1280492A (zh) 2001-01-17
IL136146A0 (en) 2001-05-20
DE69820674D1 (de) 2004-01-29
SK6602000A3 (en) 2001-01-18
NZ504353A (en) 2001-10-26
ID24700A (id) 2000-08-03
TW524694B (en) 2003-03-21
NO20002719D0 (no) 2000-05-26
KR20010032557A (ko) 2001-04-25

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