DK101589A - 6-substituerede purinylpiperazinderivater - Google Patents
6-substituerede purinylpiperazinderivaterInfo
- Publication number
- DK101589A DK101589A DK101589A DK101589A DK101589A DK 101589 A DK101589 A DK 101589A DK 101589 A DK101589 A DK 101589A DK 101589 A DK101589 A DK 101589A DK 101589 A DK101589 A DK 101589A
- Authority
- DK
- Denmark
- Prior art keywords
- piperazine derivatives
- substituted purinyl
- purinyl piperazine
- derivatives
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/163,487 US4876257A (en) | 1988-03-03 | 1988-03-03 | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DK101589D0 DK101589D0 (da) | 1989-03-02 |
DK101589A true DK101589A (da) | 1989-09-04 |
Family
ID=22590215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK101589A DK101589A (da) | 1988-03-03 | 1989-03-02 | 6-substituerede purinylpiperazinderivater |
Country Status (20)
Country | Link |
---|---|
US (1) | US4876257A (pt) |
EP (1) | EP0331511B1 (pt) |
JP (1) | JPH0826019B2 (pt) |
KR (1) | KR940002822B1 (pt) |
CN (1) | CN1031056C (pt) |
AT (1) | ATE92067T1 (pt) |
AU (1) | AU614583B2 (pt) |
DE (1) | DE68907750T2 (pt) |
DK (1) | DK101589A (pt) |
ES (1) | ES2059724T3 (pt) |
FI (1) | FI92587C (pt) |
HU (1) | HU205760B (pt) |
IE (1) | IE63457B1 (pt) |
IL (1) | IL89458A (pt) |
MY (1) | MY104959A (pt) |
NO (1) | NO171500C (pt) |
NZ (1) | NZ228167A (pt) |
PH (1) | PH26971A (pt) |
PT (1) | PT89903B (pt) |
ZA (1) | ZA891623B (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057517A (en) * | 1987-07-20 | 1991-10-15 | Merck & Co., Inc. | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents |
US5021574A (en) * | 1988-03-03 | 1991-06-04 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
US4885300A (en) * | 1988-03-03 | 1989-12-05 | Ortho Pharmaceutical Corporation | 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives |
US5164390A (en) * | 1988-03-03 | 1992-11-17 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
AU648070B2 (en) * | 1990-04-23 | 1994-04-14 | Ortho Pharmaceutical Corporation | Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives |
NZ237766A (en) | 1990-04-23 | 1993-03-26 | Ortho Pharma Corp | Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates |
US5215987A (en) * | 1990-04-23 | 1993-06-01 | Ortho Pharmaceutical Corporation | Substituted benzhydryl 2-hydroxypropyl piperazine derivatives |
US5252569A (en) * | 1990-05-23 | 1993-10-12 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
NZ238122A (en) * | 1990-05-23 | 1994-01-26 | Ortho Pharma Corp | 6-substituted purinyl piperazine derivatives and pharmaceutical |
JP3357879B2 (ja) * | 1992-02-13 | 2002-12-16 | メレルダウファーマス−ティカルズ インコーポレイテッド | ピペリジニルチア環状誘導体類 |
WO1993023386A1 (en) * | 1992-05-15 | 1993-11-25 | Mitsui Toatsu Chemicals, Incorporated | Process for producing glycide derivative |
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
US6087512A (en) * | 1996-09-18 | 2000-07-11 | Daiso Co., Ltd. | Process for preparation of glycidyl ether |
WO1998012171A1 (fr) * | 1996-09-18 | 1998-03-26 | Daiso Co., Ltd. | Procede de preparation d'ethers 3-amino-2-hydroxy-1-propyliques |
DE69832715T2 (de) * | 1997-07-12 | 2007-01-11 | Cancer Research Technology Ltd. | Cyclin-abhängige-kinase inhibierende purinderivate |
KR20030025153A (ko) * | 2001-09-19 | 2003-03-28 | 이보섭 | 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물 |
AU2004209522A1 (en) * | 2003-01-17 | 2004-08-19 | Gilead Palo Alto, Inc. | Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases |
CA3068254A1 (en) | 2017-06-20 | 2018-12-27 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3238207A (en) * | 1960-03-01 | 1966-03-01 | Burroughs Wellcome Co | 6-oxyorganopurines and method of preparing them |
US3232937A (en) * | 1962-08-02 | 1966-02-01 | Burroughs Wellcome Co | 6-benzylmercaptopurines |
US3135754A (en) * | 1962-08-09 | 1964-06-02 | Burroughs Wellcome Co | Purine derivatives |
GB1133989A (en) * | 1964-12-08 | 1968-11-20 | Chugai Pharmaceutical Co Ltd | Theophylline derivatives, their salts and process for preparing the same |
DE1620576A1 (de) * | 1966-11-25 | 1970-02-26 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen |
ES377662A1 (es) * | 1969-03-28 | 1973-01-01 | Walter Bestian | Procedimiento para la preparacion de nuevos compuestos de derivados de dialcohil-xantina. |
DE2334009A1 (de) * | 1973-07-04 | 1975-01-23 | Boehringer Mannheim Gmbh | Purin-derivate sowie verfahren zu ihrer herstellung |
US4189579A (en) * | 1977-05-20 | 1980-02-19 | The Dow Chemical Company | Aminoalkylthiopurines |
US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
EP0087810B1 (en) * | 1982-03-02 | 1986-06-25 | Eisai Co., Ltd. | Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient |
DK157135C (da) * | 1982-04-07 | 1990-04-02 | Pfizer | Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf |
DE3703633A1 (de) * | 1986-02-14 | 1987-08-20 | Sandoz Ag | Purin-derivate, ihre herstellung und sie enthaltende arzneimittel |
US4710572A (en) * | 1986-07-30 | 1987-12-01 | American Home Products Corporation | Histamine H1 antagonists |
-
1988
- 1988-03-03 US US07/163,487 patent/US4876257A/en not_active Expired - Fee Related
-
1989
- 1989-02-28 NZ NZ228167A patent/NZ228167A/xx unknown
- 1989-03-01 AU AU30882/89A patent/AU614583B2/en not_active Ceased
- 1989-03-02 DK DK101589A patent/DK101589A/da unknown
- 1989-03-02 IE IE68489A patent/IE63457B1/en not_active IP Right Cessation
- 1989-03-02 IL IL89458A patent/IL89458A/xx not_active IP Right Cessation
- 1989-03-02 NO NO890893A patent/NO171500C/no unknown
- 1989-03-02 ZA ZA891623A patent/ZA891623B/xx unknown
- 1989-03-02 MY MYPI89000259A patent/MY104959A/en unknown
- 1989-03-02 FI FI891003A patent/FI92587C/fi not_active IP Right Cessation
- 1989-03-03 HU HU891033A patent/HU205760B/hu not_active IP Right Cessation
- 1989-03-03 PT PT89903A patent/PT89903B/pt not_active IP Right Cessation
- 1989-03-03 ES ES89302141T patent/ES2059724T3/es not_active Expired - Lifetime
- 1989-03-03 DE DE89302141T patent/DE68907750T2/de not_active Expired - Fee Related
- 1989-03-03 AT AT89302141T patent/ATE92067T1/de not_active IP Right Cessation
- 1989-03-03 EP EP89302141A patent/EP0331511B1/en not_active Expired - Lifetime
- 1989-03-03 JP JP1051804A patent/JPH0826019B2/ja not_active Expired - Lifetime
- 1989-03-03 PH PH38279A patent/PH26971A/en unknown
- 1989-03-03 KR KR1019890002603A patent/KR940002822B1/ko not_active IP Right Cessation
- 1989-03-03 CN CN89102516A patent/CN1031056C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE68907750T2 (de) | 1994-01-05 |
JPH01279887A (ja) | 1989-11-10 |
AU3088289A (en) | 1989-09-07 |
US4876257A (en) | 1989-10-24 |
IE63457B1 (en) | 1995-04-19 |
KR890014538A (ko) | 1989-10-24 |
IL89458A (en) | 1993-07-08 |
JPH0826019B2 (ja) | 1996-03-13 |
PT89903A (pt) | 1989-11-10 |
DE68907750D1 (de) | 1993-09-02 |
NZ228167A (en) | 1991-08-27 |
NO171500C (no) | 1993-03-24 |
PH26971A (en) | 1992-12-28 |
AU614583B2 (en) | 1991-09-05 |
DK101589D0 (da) | 1989-03-02 |
IL89458A0 (en) | 1989-09-10 |
FI891003A (fi) | 1989-09-04 |
KR940002822B1 (ko) | 1994-04-04 |
HUT49352A (en) | 1989-09-28 |
ATE92067T1 (de) | 1993-08-15 |
ZA891623B (en) | 1990-11-28 |
NO171500B (no) | 1992-12-14 |
FI92587C (fi) | 1994-12-12 |
IE890684L (en) | 1989-09-03 |
CN1031056C (zh) | 1996-02-21 |
NO890893D0 (no) | 1989-03-02 |
HU205760B (en) | 1992-06-29 |
FI92587B (fi) | 1994-08-31 |
PT89903B (pt) | 1994-05-31 |
NO890893L (no) | 1989-09-04 |
ES2059724T3 (es) | 1994-11-16 |
MY104959A (en) | 1994-07-30 |
EP0331511A1 (en) | 1989-09-06 |
FI891003A0 (fi) | 1989-03-02 |
CN1036765A (zh) | 1989-11-01 |
EP0331511B1 (en) | 1993-07-28 |
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