NO171500C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater

Info

Publication number
NO171500C
NO171500C NO890893A NO890893A NO171500C NO 171500 C NO171500 C NO 171500C NO 890893 A NO890893 A NO 890893A NO 890893 A NO890893 A NO 890893A NO 171500 C NO171500 C NO 171500C
Authority
NO
Norway
Prior art keywords
derivatives
substituted
purinylpiperazine
preparation
therapeutic active
Prior art date
Application number
NO890893A
Other languages
English (en)
Other versions
NO890893D0 (no
NO171500B (no
NO890893L (no
Inventor
Zoltan G Hajos
Ramesh M Kanojia
Jeffrey B Press
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of NO890893D0 publication Critical patent/NO890893D0/no
Publication of NO890893L publication Critical patent/NO890893L/no
Publication of NO171500B publication Critical patent/NO171500B/no
Publication of NO171500C publication Critical patent/NO171500C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO890893A 1988-03-03 1989-03-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater NO171500C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/163,487 US4876257A (en) 1988-03-03 1988-03-03 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

Publications (4)

Publication Number Publication Date
NO890893D0 NO890893D0 (no) 1989-03-02
NO890893L NO890893L (no) 1989-09-04
NO171500B NO171500B (no) 1992-12-14
NO171500C true NO171500C (no) 1993-03-24

Family

ID=22590215

Family Applications (1)

Application Number Title Priority Date Filing Date
NO890893A NO171500C (no) 1988-03-03 1989-03-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater

Country Status (20)

Country Link
US (1) US4876257A (no)
EP (1) EP0331511B1 (no)
JP (1) JPH0826019B2 (no)
KR (1) KR940002822B1 (no)
CN (1) CN1031056C (no)
AT (1) ATE92067T1 (no)
AU (1) AU614583B2 (no)
DE (1) DE68907750T2 (no)
DK (1) DK101589A (no)
ES (1) ES2059724T3 (no)
FI (1) FI92587C (no)
HU (1) HU205760B (no)
IE (1) IE63457B1 (no)
IL (1) IL89458A (no)
MY (1) MY104959A (no)
NO (1) NO171500C (no)
NZ (1) NZ228167A (no)
PH (1) PH26971A (no)
PT (1) PT89903B (no)
ZA (1) ZA891623B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
AU648070B2 (en) * 1990-04-23 1994-04-14 Ortho Pharmaceutical Corporation Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
US5215987A (en) * 1990-04-23 1993-06-01 Ortho Pharmaceutical Corporation Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
NZ237766A (en) 1990-04-23 1993-03-26 Ortho Pharma Corp Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates
US5252569A (en) * 1990-05-23 1993-10-12 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
NZ238122A (en) * 1990-05-23 1994-01-26 Ortho Pharma Corp 6-substituted purinyl piperazine derivatives and pharmaceutical
DE69330823T2 (de) * 1992-02-13 2002-05-02 Merrell Pharma Inc Thiacyclische piperidinylderivate
WO1993023386A1 (en) * 1992-05-15 1993-11-25 Mitsui Toatsu Chemicals, Incorporated Process for producing glycide derivative
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
AU4219897A (en) * 1996-09-18 1998-04-14 Daiso Co. Ltd. Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
DE69717653T2 (de) * 1996-09-18 2003-09-25 Daiso Co Ltd Verfahren zur herstellung von glycidylethern
DE69832715T2 (de) * 1997-07-12 2007-01-11 Cancer Research Technology Ltd. Cyclin-abhängige-kinase inhibierende purinderivate
KR20030025153A (ko) * 2001-09-19 2003-03-28 이보섭 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
JP2006515891A (ja) * 2003-01-17 2006-06-08 シーブイ・セラピューティクス・インコーポレイテッド 循環器疾患の処置に有効な置換ヘテロ環化合物
CA3068254A1 (en) 2017-06-20 2018-12-27 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238207A (en) * 1960-03-01 1966-03-01 Burroughs Wellcome Co 6-oxyorganopurines and method of preparing them
US3232937A (en) * 1962-08-02 1966-02-01 Burroughs Wellcome Co 6-benzylmercaptopurines
US3135754A (en) * 1962-08-09 1964-06-02 Burroughs Wellcome Co Purine derivatives
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) * 1966-11-25 1970-02-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
GB1289287A (no) * 1969-03-28 1972-09-13
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
US4189579A (en) * 1977-05-20 1980-02-19 The Dow Chemical Company Aminoalkylthiopurines
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
IT1161591B (it) * 1982-03-02 1987-03-18 Eisai Co Ltd Agenti antiflogistici/antipiretici/analgesici contenenti derivati di teobromina o teofillina come ingrediente attivo
DK157135C (da) * 1982-04-07 1990-04-02 Pfizer Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DE3703633A1 (de) * 1986-02-14 1987-08-20 Sandoz Ag Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4710572A (en) * 1986-07-30 1987-12-01 American Home Products Corporation Histamine H1 antagonists

Also Published As

Publication number Publication date
JPH0826019B2 (ja) 1996-03-13
KR940002822B1 (ko) 1994-04-04
IL89458A (en) 1993-07-08
FI891003A0 (fi) 1989-03-02
CN1031056C (zh) 1996-02-21
IE63457B1 (en) 1995-04-19
NZ228167A (en) 1991-08-27
AU614583B2 (en) 1991-09-05
DK101589D0 (da) 1989-03-02
US4876257A (en) 1989-10-24
AU3088289A (en) 1989-09-07
NO890893D0 (no) 1989-03-02
CN1036765A (zh) 1989-11-01
DK101589A (da) 1989-09-04
JPH01279887A (ja) 1989-11-10
FI92587C (fi) 1994-12-12
EP0331511B1 (en) 1993-07-28
DE68907750D1 (de) 1993-09-02
IE890684L (en) 1989-09-03
PT89903A (pt) 1989-11-10
FI92587B (fi) 1994-08-31
PH26971A (en) 1992-12-28
KR890014538A (ko) 1989-10-24
FI891003A (fi) 1989-09-04
DE68907750T2 (de) 1994-01-05
EP0331511A1 (en) 1989-09-06
PT89903B (pt) 1994-05-31
ZA891623B (en) 1990-11-28
IL89458A0 (en) 1989-09-10
HUT49352A (en) 1989-09-28
ES2059724T3 (es) 1994-11-16
ATE92067T1 (de) 1993-08-15
NO171500B (no) 1992-12-14
MY104959A (en) 1994-07-30
NO890893L (no) 1989-09-04
HU205760B (en) 1992-06-29

Similar Documents

Publication Publication Date Title
NO171500C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater
ATE116310T1 (de) Benzo(5,6)cycloheptapyridine, zusammensetzungen und verwendung.
ATE114650T1 (de) Heterocyclische n-oxid-derivate substituierter benzo(5,6>cycloheptapyridine, zusammensetzungen und methoden der verwendung.
NO172801C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinuklidin-derivater
NO167142C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater.
NO169839C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa, alfa -(iminobis(metylen))bis(3,4-dihydro-2h-1-benzopyran-2-metanol)derivater
NO162514C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinonderivater.
NO170629C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater
NO169014C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive distamycinderivater
NO165922C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.
NO901008L (no) Fremgangsmaate for fremstilling av (3-(c16-c18)alkansulfinyl- og sulfonyl-2-methoxymethyl-propyl)-(2-trimethylaminio-ethyl)-fosfater.
NO171412C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
NO171909C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater
NO168299C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater
DE3688721D1 (de) Verwendung von porphyrinderivaten bei der entdeckung und behandlung von tumoren.
NO172490C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-disubstituerte piperazinderivater
NO171857C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater
NO169069C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-alkoksy-2-aminopropylaminderivater
NO169648C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater
NO171847C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzenderivater
NO171211C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner
ES2061481T3 (es) Derivados de 3,4-dihidrobenzoazina opticamente activos y procedimiento para la preparacion de los mismos.
NO168103C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive aralkylimidazolderivater
NO164650C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-(acetylaminofenyl)-2-aminopropanon-derivater.
MY104804A (en) Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives