DE68907750D1 - 6-substituierte purinylpiperazinderivate. - Google Patents

6-substituierte purinylpiperazinderivate.

Info

Publication number
DE68907750D1
DE68907750D1 DE8989302141T DE68907750T DE68907750D1 DE 68907750 D1 DE68907750 D1 DE 68907750D1 DE 8989302141 T DE8989302141 T DE 8989302141T DE 68907750 T DE68907750 T DE 68907750T DE 68907750 D1 DE68907750 D1 DE 68907750D1
Authority
DE
Germany
Prior art keywords
piperazine derivatives
substituted purinyl
purinyl piperazine
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989302141T
Other languages
English (en)
Other versions
DE68907750T2 (de
Inventor
Zoltan G Hajos
Ramesh M Kanojia
Jeffrey B Press
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of DE68907750D1 publication Critical patent/DE68907750D1/de
Application granted granted Critical
Publication of DE68907750T2 publication Critical patent/DE68907750T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE89302141T 1988-03-03 1989-03-03 6-Substituierte Purinylpiperazinderivate. Expired - Fee Related DE68907750T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/163,487 US4876257A (en) 1988-03-03 1988-03-03 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

Publications (2)

Publication Number Publication Date
DE68907750D1 true DE68907750D1 (de) 1993-09-02
DE68907750T2 DE68907750T2 (de) 1994-01-05

Family

ID=22590215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89302141T Expired - Fee Related DE68907750T2 (de) 1988-03-03 1989-03-03 6-Substituierte Purinylpiperazinderivate.

Country Status (20)

Country Link
US (1) US4876257A (de)
EP (1) EP0331511B1 (de)
JP (1) JPH0826019B2 (de)
KR (1) KR940002822B1 (de)
CN (1) CN1031056C (de)
AT (1) ATE92067T1 (de)
AU (1) AU614583B2 (de)
DE (1) DE68907750T2 (de)
DK (1) DK101589A (de)
ES (1) ES2059724T3 (de)
FI (1) FI92587C (de)
HU (1) HU205760B (de)
IE (1) IE63457B1 (de)
IL (1) IL89458A (de)
MY (1) MY104959A (de)
NO (1) NO171500C (de)
NZ (1) NZ228167A (de)
PH (1) PH26971A (de)
PT (1) PT89903B (de)
ZA (1) ZA891623B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
AU648070B2 (en) * 1990-04-23 1994-04-14 Ortho Pharmaceutical Corporation Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
US5215987A (en) * 1990-04-23 1993-06-01 Ortho Pharmaceutical Corporation Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
NZ237766A (en) 1990-04-23 1993-03-26 Ortho Pharma Corp Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates
NZ238122A (en) * 1990-05-23 1994-01-26 Ortho Pharma Corp 6-substituted purinyl piperazine derivatives and pharmaceutical
US5252569A (en) * 1990-05-23 1993-10-12 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
WO1993023386A1 (en) * 1992-05-15 1993-11-25 Mitsui Toatsu Chemicals, Incorporated Process for producing glycide derivative
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
US6057476A (en) * 1996-09-18 2000-05-02 Daiso Co., Ltd. Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
AU4219997A (en) * 1996-09-18 1998-04-14 Daiso Co. Ltd. Process for the preparation of glycidyl ethers
AU744986B2 (en) * 1997-07-12 2002-03-07 Cancer Research Technology Limited Cyclin dependent kinase inhibiting purine derivatives
KR20030025153A (ko) * 2001-09-19 2003-03-28 이보섭 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
CA2513529A1 (en) * 2003-01-17 2004-08-19 Cv Therapeutics Inc. Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases
ES2919779T3 (es) 2017-06-20 2022-07-28 Imbria Pharmaceuticals Inc Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238207A (en) * 1960-03-01 1966-03-01 Burroughs Wellcome Co 6-oxyorganopurines and method of preparing them
US3232937A (en) * 1962-08-02 1966-02-01 Burroughs Wellcome Co 6-benzylmercaptopurines
US3135754A (en) * 1962-08-09 1964-06-02 Burroughs Wellcome Co Purine derivatives
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) * 1966-11-25 1970-02-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
ES377662A1 (es) * 1969-03-28 1973-01-01 Walter Bestian Procedimiento para la preparacion de nuevos compuestos de derivados de dialcohil-xantina.
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
US4189579A (en) * 1977-05-20 1980-02-19 The Dow Chemical Company Aminoalkylthiopurines
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3307395A1 (de) * 1982-03-02 1983-09-08 Eisai Co., Ltd., Tokyo Arzneimittel zur behandlung von schmerzen, fieber, gewebe- und/oder knochen- und gelenkentzuendungen mit einem gehalt an theobromin- oder theophyllinderivaten als aktivem bestandteil
DK157135C (da) * 1982-04-07 1990-04-02 Pfizer Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DE3703633A1 (de) * 1986-02-14 1987-08-20 Sandoz Ag Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4710572A (en) * 1986-07-30 1987-12-01 American Home Products Corporation Histamine H1 antagonists

Also Published As

Publication number Publication date
NO890893L (no) 1989-09-04
EP0331511A1 (de) 1989-09-06
IE890684L (en) 1989-09-03
CN1031056C (zh) 1996-02-21
NO171500B (no) 1992-12-14
CN1036765A (zh) 1989-11-01
MY104959A (en) 1994-07-30
JPH0826019B2 (ja) 1996-03-13
PH26971A (en) 1992-12-28
NZ228167A (en) 1991-08-27
JPH01279887A (ja) 1989-11-10
FI891003A (fi) 1989-09-04
NO890893D0 (no) 1989-03-02
PT89903A (pt) 1989-11-10
DK101589D0 (da) 1989-03-02
FI92587B (fi) 1994-08-31
IE63457B1 (en) 1995-04-19
KR940002822B1 (ko) 1994-04-04
IL89458A (en) 1993-07-08
PT89903B (pt) 1994-05-31
KR890014538A (ko) 1989-10-24
ATE92067T1 (de) 1993-08-15
IL89458A0 (en) 1989-09-10
ZA891623B (en) 1990-11-28
DK101589A (da) 1989-09-04
FI891003A0 (fi) 1989-03-02
FI92587C (fi) 1994-12-12
AU3088289A (en) 1989-09-07
HU205760B (en) 1992-06-29
AU614583B2 (en) 1991-09-05
HUT49352A (en) 1989-09-28
DE68907750T2 (de) 1994-01-05
NO171500C (no) 1993-03-24
US4876257A (en) 1989-10-24
ES2059724T3 (es) 1994-11-16
EP0331511B1 (de) 1993-07-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee