IL89458A - 4-piperazinyl and 4-piperidinylmethylaryl derivatives substituted in the 1-position by a propyl group substituted by a 6-purinyl-containing moiety, their preparation and pharmaceutical compositions containing them - Google Patents

4-piperazinyl and 4-piperidinylmethylaryl derivatives substituted in the 1-position by a propyl group substituted by a 6-purinyl-containing moiety, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL89458A
IL89458A IL89458A IL8945889A IL89458A IL 89458 A IL89458 A IL 89458A IL 89458 A IL89458 A IL 89458A IL 8945889 A IL8945889 A IL 8945889A IL 89458 A IL89458 A IL 89458A
Authority
IL
Israel
Prior art keywords
piperidinylmethylaryl
purinyl
piperazinyl
preparation
substituted
Prior art date
Application number
IL89458A
Other languages
English (en)
Other versions
IL89458A0 (en
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of IL89458A0 publication Critical patent/IL89458A0/xx
Publication of IL89458A publication Critical patent/IL89458A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL89458A 1988-03-03 1989-03-02 4-piperazinyl and 4-piperidinylmethylaryl derivatives substituted in the 1-position by a propyl group substituted by a 6-purinyl-containing moiety, their preparation and pharmaceutical compositions containing them IL89458A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/163,487 US4876257A (en) 1988-03-03 1988-03-03 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

Publications (2)

Publication Number Publication Date
IL89458A0 IL89458A0 (en) 1989-09-10
IL89458A true IL89458A (en) 1993-07-08

Family

ID=22590215

Family Applications (1)

Application Number Title Priority Date Filing Date
IL89458A IL89458A (en) 1988-03-03 1989-03-02 4-piperazinyl and 4-piperidinylmethylaryl derivatives substituted in the 1-position by a propyl group substituted by a 6-purinyl-containing moiety, their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4876257A (de)
EP (1) EP0331511B1 (de)
JP (1) JPH0826019B2 (de)
KR (1) KR940002822B1 (de)
CN (1) CN1031056C (de)
AT (1) ATE92067T1 (de)
AU (1) AU614583B2 (de)
DE (1) DE68907750T2 (de)
DK (1) DK101589A (de)
ES (1) ES2059724T3 (de)
FI (1) FI92587C (de)
HU (1) HU205760B (de)
IE (1) IE63457B1 (de)
IL (1) IL89458A (de)
MY (1) MY104959A (de)
NO (1) NO171500C (de)
NZ (1) NZ228167A (de)
PH (1) PH26971A (de)
PT (1) PT89903B (de)
ZA (1) ZA891623B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
AU648070B2 (en) * 1990-04-23 1994-04-14 Ortho Pharmaceutical Corporation Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
NZ237766A (en) 1990-04-23 1993-03-26 Ortho Pharma Corp Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates
US5215987A (en) * 1990-04-23 1993-06-01 Ortho Pharmaceutical Corporation Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
US5252569A (en) * 1990-05-23 1993-10-12 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
NZ238122A (en) * 1990-05-23 1994-01-26 Ortho Pharma Corp 6-substituted purinyl piperazine derivatives and pharmaceutical
DK0626968T3 (da) * 1992-02-13 2001-12-31 Merrell Pharma Inc Thiacykliske piperidinylderivater
EP0603404B1 (de) * 1992-05-15 1999-03-17 Mitsui Chemicals, Inc. Verfahren zur herstellung von glycidderivaten
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
EP0930291B1 (de) * 1996-09-18 2002-08-14 Daiso Co., Ltd. Verfahren zur herstellung von 3-amino-2-hydroxy-1-propylethern
DE69717653T2 (de) * 1996-09-18 2003-09-25 Daiso Co., Ltd. Verfahren zur herstellung von glycidylethern
AU744986B2 (en) * 1997-07-12 2002-03-07 Cancer Research Technology Limited Cyclin dependent kinase inhibiting purine derivatives
KR20030025153A (ko) * 2001-09-19 2003-03-28 이보섭 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
CA2513529A1 (en) * 2003-01-17 2004-08-19 Cv Therapeutics Inc. Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases
KR102704242B1 (ko) 2017-06-20 2024-09-09 임브리아 파마슈티칼스, 인크. 심장 대사의 효율을 증가시키기 위한 조성물 및 방법
US12318382B2 (en) 2018-10-17 2025-06-03 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
WO2020243120A1 (en) 2019-05-31 2020-12-03 Imbria Pharmaceuticals, Inc. Methods of treating fibrosis using compounds that promote glucose oxidation
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238207A (en) * 1960-03-01 1966-03-01 Burroughs Wellcome Co 6-oxyorganopurines and method of preparing them
US3232937A (en) * 1962-08-02 1966-02-01 Burroughs Wellcome Co 6-benzylmercaptopurines
US3135754A (en) * 1962-08-09 1964-06-02 Burroughs Wellcome Co Purine derivatives
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) * 1966-11-25 1970-02-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
ES377662A1 (es) * 1969-03-28 1973-01-01 Walter Bestian Procedimiento para la preparacion de nuevos compuestos de derivados de dialcohil-xantina.
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
US4189579A (en) * 1977-05-20 1980-02-19 The Dow Chemical Company Aminoalkylthiopurines
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3307395A1 (de) * 1982-03-02 1983-09-08 Eisai Co., Ltd., Tokyo Arzneimittel zur behandlung von schmerzen, fieber, gewebe- und/oder knochen- und gelenkentzuendungen mit einem gehalt an theobromin- oder theophyllinderivaten als aktivem bestandteil
DK157135C (da) * 1982-04-07 1990-04-02 Pfizer Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DE3703633A1 (de) * 1986-02-14 1987-08-20 Sandoz Ag Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4710572A (en) * 1986-07-30 1987-12-01 American Home Products Corporation Histamine H1 antagonists

Also Published As

Publication number Publication date
FI92587C (fi) 1994-12-12
IE63457B1 (en) 1995-04-19
JPH01279887A (ja) 1989-11-10
PT89903B (pt) 1994-05-31
EP0331511B1 (de) 1993-07-28
US4876257A (en) 1989-10-24
NO890893L (no) 1989-09-04
JPH0826019B2 (ja) 1996-03-13
DE68907750T2 (de) 1994-01-05
NZ228167A (en) 1991-08-27
NO890893D0 (no) 1989-03-02
NO171500C (no) 1993-03-24
CN1036765A (zh) 1989-11-01
DE68907750D1 (de) 1993-09-02
FI891003A0 (fi) 1989-03-02
NO171500B (no) 1992-12-14
ZA891623B (en) 1990-11-28
DK101589D0 (da) 1989-03-02
PT89903A (pt) 1989-11-10
DK101589A (da) 1989-09-04
ATE92067T1 (de) 1993-08-15
PH26971A (en) 1992-12-28
FI92587B (fi) 1994-08-31
KR890014538A (ko) 1989-10-24
EP0331511A1 (de) 1989-09-06
MY104959A (en) 1994-07-30
HUT49352A (en) 1989-09-28
HU205760B (en) 1992-06-29
ES2059724T3 (es) 1994-11-16
FI891003A7 (fi) 1989-09-04
AU614583B2 (en) 1991-09-05
IE890684L (en) 1989-09-03
IL89458A0 (en) 1989-09-10
CN1031056C (zh) 1996-02-21
KR940002822B1 (ko) 1994-04-04
AU3088289A (en) 1989-09-07

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