DK0985032T4 - Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner - Google Patents

Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Info

Publication number
DK0985032T4
DK0985032T4 DK98924468T DK98924468T DK0985032T4 DK 0985032 T4 DK0985032 T4 DK 0985032T4 DK 98924468 T DK98924468 T DK 98924468T DK 98924468 T DK98924468 T DK 98924468T DK 0985032 T4 DK0985032 T4 DK 0985032T4
Authority
DK
Denmark
Prior art keywords
complexes
protein
peptide
mrna
antibody
Prior art date
Application number
DK98924468T
Other languages
Danish (da)
English (en)
Other versions
DK0985032T3 (da
Inventor
Michael John Taussig
Mingyue He
Original Assignee
Crescendo Biolog Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0985032(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9710829.4A external-priority patent/GB9710829D0/en
Priority claimed from GBGB9724850.4A external-priority patent/GB9724850D0/en
Priority claimed from GBGB9804195.7A external-priority patent/GB9804195D0/en
Application filed by Crescendo Biolog Ltd filed Critical Crescendo Biolog Ltd
Application granted granted Critical
Publication of DK0985032T3 publication Critical patent/DK0985032T3/da
Publication of DK0985032T4 publication Critical patent/DK0985032T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1041Ribosome/Polysome display, e.g. SPERT, ARM
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK98924468T 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner DK0985032T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710829.4A GB9710829D0 (en) 1997-05-28 1997-05-28 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9724850.4A GB9724850D0 (en) 1997-11-26 1997-11-26 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9804195.7A GB9804195D0 (en) 1998-02-28 1998-02-28 Selection particles for in vitro display and evolution of antibody combining sites
PCT/GB1998/001564 WO1998054312A1 (en) 1997-05-28 1998-05-28 Ribosome complexes as selection particles for in vitro display and evolution of proteins

Publications (2)

Publication Number Publication Date
DK0985032T3 DK0985032T3 (da) 2004-02-02
DK0985032T4 true DK0985032T4 (da) 2009-08-31

Family

ID=27268863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98924468T DK0985032T4 (da) 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Country Status (10)

Country Link
US (1) US6620587B1 (es)
EP (1) EP0985032B2 (es)
JP (1) JP4060892B2 (es)
AT (1) ATE250668T1 (es)
CA (1) CA2291721C (es)
DE (1) DE69818458T3 (es)
DK (1) DK0985032T4 (es)
ES (1) ES2209145T5 (es)
PT (1) PT985032E (es)
WO (1) WO1998054312A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4854999A (en) * 1998-07-02 2000-01-24 Invitro Diagnostics, Inc. Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
DE19932688B4 (de) * 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
GB9917027D0 (en) * 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
SG121902A1 (en) * 2000-01-11 2006-05-26 Maxygen Inc Integrated systems for diversity generation and screening
EP1652919A1 (en) * 2000-03-31 2006-05-03 Cambridge Antibody Technology LTD Improvements to ribosome display
CA2402452A1 (en) * 2000-03-31 2001-10-11 Cambridge Antibody Technology Limited Improvements to ribosome display
US7129326B2 (en) 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
ATE455304T1 (de) 2000-04-14 2010-01-15 Genencor Int Verfahren zur selektiven zielen
CA2440649A1 (en) 2001-03-07 2002-09-19 Children's Medical Center Corporation Method to screen peptide display libraries using minicell display
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
DE10145226A1 (de) * 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
WO2003078626A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of transferring a functional entity
EP1487978B1 (en) 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
WO2003078446A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
AU2003253069A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c bond upon reaction
EP1539980B1 (en) * 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004022746A1 (en) * 2002-09-06 2004-03-18 Isogenica Limited In vitro peptide expression libraray
AU2003273792B2 (en) 2002-10-30 2011-07-07 Nuevolution A/S Method for the synthesis of a bifunctional complex
EP1572723B1 (en) 2002-11-25 2013-02-27 Danisco US Inc. Skin binding peptides
EP2175019A3 (en) * 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US7572577B2 (en) * 2003-03-19 2009-08-11 Crescendo Biologics Limited Methods for recovery of DNA from mRNA in ribosome display complexes
WO2004083427A2 (en) * 2003-03-20 2004-09-30 Nuevolution A/S Ligational encoding of small molecules
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
GB0316314D0 (en) * 2003-07-12 2003-08-13 Univ Belfast Method
DE602004023960D1 (de) * 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
EP1730277B1 (en) * 2004-03-22 2009-10-28 Nuevolution A/S Ligational encoding using building block oligonucleotides
US20050250112A1 (en) * 2004-05-07 2005-11-10 Padmabandu Gothami A Nucleic acids, compositions, methods, and kits for detecting mycoplasma and acholeplasma species
US9006393B1 (en) 2004-08-26 2015-04-14 Patricia L. Clark Molecular constructs and uses thereof in ribosomal translational events
DE102004049479A1 (de) 2004-10-11 2006-04-13 Scil Proteins Gmbh Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
WO2007062664A2 (en) 2005-12-01 2007-06-07 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US7777002B2 (en) * 2006-06-29 2010-08-17 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7816101B2 (en) * 2006-06-29 2010-10-19 The Invention Science Fund I, Llc Apparatus for arbitrary peptide synthesis
US7879975B2 (en) * 2006-06-29 2011-02-01 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7923533B2 (en) * 2006-06-29 2011-04-12 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7910695B2 (en) 2006-06-29 2011-03-22 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
US8865179B2 (en) * 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
CN102177438A (zh) * 2008-07-25 2011-09-07 理查德·W·瓦格纳 蛋白筛选方法
CA2737035A1 (en) * 2008-09-30 2010-04-08 Abbott Laboratories Improved method of rna display
EP2379581B1 (en) 2009-12-14 2013-10-09 Scil Proteins GmbH A method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands
EP2546342A4 (en) 2010-03-11 2013-12-04 Riken METHOD FOR SELECTION OF A POLYPEPTIDE SEQUENCE, METAL OXIDE OR SILICON WITH A BONDING SPEPTIDE AND USE THEREOF
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
EP2627781B1 (en) 2010-10-15 2017-02-22 Olink Bioscience AB Dynamic range methods
EP2466310A1 (en) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Means and methods for detecting double-strand breaks
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
WO2012161227A1 (ja) 2011-05-23 2012-11-29 独立行政法人理化学研究所 核酸構築物、核酸-蛋白質複合体、及びその利用
WO2012172055A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Dimeric binding proteins based on modified ubiquitins
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
WO2015120058A2 (en) 2014-02-05 2015-08-13 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
EP3209776A1 (en) * 2014-10-22 2017-08-30 Crescendo Biologics Limited Human vh domain scaffolds
EP3253785B1 (en) 2015-02-06 2019-04-10 Navigo Proteins Gmbh Novel egfr binding proteins
EP3322721B1 (en) 2015-07-16 2021-12-08 Navigo Proteins Gmbh Novel immunoglobulin-binding proteins and their use in affinity purification
CA2991815A1 (en) 2015-07-20 2017-01-26 Navigo Proteins Gmbh Novel binding proteins based on di-ubiquitin muteins and methods for generation
AU2016326737B2 (en) 2015-09-24 2023-01-12 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
WO2018057051A1 (en) 2016-09-24 2018-03-29 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
CA3022751A1 (en) 2016-05-04 2017-11-09 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
CN109476712B (zh) 2016-08-11 2022-08-02 纳维格蛋白质有限公司 新型对碱稳定的免疫球蛋白结合蛋白
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
US20210040472A1 (en) 2019-08-09 2021-02-11 Nutcracker Therapeutics, Inc. Methods and apparatuses for manufacturing for removing material from a therapeutic composition
EP4382534A1 (en) 2022-12-06 2024-06-12 Biomérieux Synthetic peptide for use in an immunomolecular assay
WO2024156899A1 (en) 2023-01-27 2024-08-02 Biomerieux Modified immuno-molecular assay for faster biomarker detection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06178688A (ja) 1992-12-11 1994-06-28 Mitsui Toatsu Chem Inc E型緑膿菌を抗原とするヒト抗体をコードする遺伝子
WO1995011922A1 (en) 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
CA2402452A1 (en) 2000-03-31 2001-10-11 Cambridge Antibody Technology Limited Improvements to ribosome display

Also Published As

Publication number Publication date
DE69818458T3 (de) 2009-12-17
CA2291721A1 (en) 1998-12-03
ES2209145T3 (es) 2004-06-16
US6620587B1 (en) 2003-09-16
DE69818458T2 (de) 2004-07-08
JP2002500514A (ja) 2002-01-08
DE69818458D1 (de) 2003-10-30
JP4060892B2 (ja) 2008-03-12
ATE250668T1 (de) 2003-10-15
EP0985032A1 (en) 2000-03-15
WO1998054312A1 (en) 1998-12-03
EP0985032B2 (en) 2009-06-03
CA2291721C (en) 2011-08-09
AU7666698A (en) 1998-12-30
ES2209145T5 (es) 2009-10-30
EP0985032B1 (en) 2003-09-24
PT985032E (pt) 2004-02-27
AU725957B2 (en) 2000-10-26
DK0985032T3 (da) 2004-02-02

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