DK0971898T3 - Substituerede isoquinoliner som ultrakortvirkende neuromuskulære blokeringsmidler - Google Patents

Substituerede isoquinoliner som ultrakortvirkende neuromuskulære blokeringsmidler

Info

Publication number
DK0971898T3
DK0971898T3 DK98912494T DK98912494T DK0971898T3 DK 0971898 T3 DK0971898 T3 DK 0971898T3 DK 98912494 T DK98912494 T DK 98912494T DK 98912494 T DK98912494 T DK 98912494T DK 0971898 T3 DK0971898 T3 DK 0971898T3
Authority
DK
Denmark
Prior art keywords
ultra
short
blocking agents
neuromuscular blocking
substituted isoquinolines
Prior art date
Application number
DK98912494T
Other languages
Danish (da)
English (en)
Inventor
Eric Cleveland Bigham
Grady Evan Boswell
Roy Archibald Swaringen Jr
Sanjay Shashikant Patel
Eric Eugene Boros
Robert Anthony Mook Jr
Vincente Samano
John Joseph Cornell R Savarese
Original Assignee
Avera Pharmaceuticals Inc
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9706117.0A external-priority patent/GB9706117D0/en
Priority claimed from GBGB9724987.4A external-priority patent/GB9724987D0/en
Application filed by Avera Pharmaceuticals Inc, Cornell Res Foundation Inc filed Critical Avera Pharmaceuticals Inc
Application granted granted Critical
Publication of DK0971898T3 publication Critical patent/DK0971898T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals
    • C07D217/20Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK98912494T 1997-03-25 1998-03-23 Substituerede isoquinoliner som ultrakortvirkende neuromuskulære blokeringsmidler DK0971898T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9706117.0A GB9706117D0 (en) 1997-03-25 1997-03-25 Ultra-short acting neuromuscular blockers
GBGB9724987.4A GB9724987D0 (en) 1997-11-27 1997-11-27 Ultra-short acting neuromuscular blockers
PCT/EP1998/001652 WO1998042675A1 (en) 1997-03-25 1998-03-23 Substituted isoquinolines as ultra short acting neuromuscular blockers
EP98912494A EP0971898B1 (de) 1997-03-25 1998-03-23 Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker

Publications (1)

Publication Number Publication Date
DK0971898T3 true DK0971898T3 (da) 2005-09-05

Family

ID=26311255

Family Applications (2)

Application Number Title Priority Date Filing Date
DK98922626T DK0975599T3 (da) 1997-03-25 1998-03-23 Substituerede isoquinoliner som ultrakort virkende neuromuskulære blokkere
DK98912494T DK0971898T3 (da) 1997-03-25 1998-03-23 Substituerede isoquinoliner som ultrakortvirkende neuromuskulære blokeringsmidler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK98922626T DK0975599T3 (da) 1997-03-25 1998-03-23 Substituerede isoquinoliner som ultrakort virkende neuromuskulære blokkere

Country Status (37)

Country Link
US (2) US6187789B1 (de)
EP (4) EP1526130A1 (de)
JP (3) JP4112016B2 (de)
KR (2) KR100554601B1 (de)
CN (1) CN1203061C (de)
AP (1) AP1797A (de)
AR (1) AR012156A1 (de)
AT (3) ATE295351T1 (de)
AU (2) AU745382B2 (de)
BR (1) BR9808422B1 (de)
CA (1) CA2284802C (de)
CO (1) CO4940499A1 (de)
CZ (1) CZ293786B6 (de)
DE (3) DE69840816D1 (de)
DK (2) DK0975599T3 (de)
EA (1) EA002224B1 (de)
EE (1) EE04113B1 (de)
ES (2) ES2210757T3 (de)
HK (1) HK1023342A1 (de)
HR (1) HRP980157B1 (de)
HU (1) HU228230B1 (de)
ID (1) ID22901A (de)
IL (1) IL131918A (de)
IS (2) IS2346B (de)
MA (1) MA26476A1 (de)
MY (1) MY121316A (de)
NO (1) NO314726B1 (de)
NZ (1) NZ337797A (de)
PE (1) PE68399A1 (de)
PL (1) PL190860B1 (de)
PT (2) PT975599E (de)
RS (1) RS49869B (de)
SI (1) SI0975599T1 (de)
TR (1) TR199902330T2 (de)
TW (1) TW505635B (de)
UY (1) UY24933A1 (de)
WO (2) WO1998042674A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2284802C (en) * 1997-03-25 2009-06-16 Cornell Research Foundation, Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
US6911455B2 (en) * 1999-12-22 2005-06-28 Smithkline Beecham Corporation Methods for preparing pharmaceutical formulations
US6844904B2 (en) * 2002-12-07 2005-01-18 Cubic Corporation Fast PDLC device
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US8148398B2 (en) * 2006-12-06 2012-04-03 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
WO2008132746A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
WO2008132748A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US20100256381A1 (en) * 2007-07-09 2010-10-07 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
BRPI0816519A2 (pt) 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en) * 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2014005122A2 (en) * 2012-06-29 2014-01-03 Savarese John J Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
WO2014210369A2 (en) * 2013-06-28 2014-12-31 Cornell University Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents
CN108375644B (zh) * 2016-12-07 2021-11-30 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的分析方法
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN110776481B (zh) * 2018-07-24 2023-06-16 四川大学华西医院 一类双阳离子化合物及其制备方法和用途
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN111662230A (zh) * 2019-03-06 2020-09-15 四川道珍科技有限公司 一类苄基异喹啉化合物、制备方法和用途
CN110117297A (zh) * 2019-04-10 2019-08-13 珠海市赛纬电子材料股份有限公司 一种2-磷酸盐基硫酸丙烯酯的制备方法
TW202128628A (zh) * 2019-12-11 2021-08-01 大陸商江蘇恆瑞醫藥股份有限公司 神經肌肉阻滯劑及其製備方法
CN111471013B (zh) * 2020-05-26 2021-04-30 朗天药业(湖北)有限公司 一种米库氯铵及其注射液的制备方法
CN111909089B (zh) * 2020-08-14 2023-04-14 广东嘉博制药有限公司 一种米库氯铵对照品的制备方法
CN114057642B (zh) * 2021-12-10 2023-03-28 广东嘉博制药有限公司 一种米库氯铵中间体的合成方法
CN115073373A (zh) * 2022-07-08 2022-09-20 广东嘉博制药有限公司 一种不对称合成(r)-5’-甲氧基劳丹素的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
ZA784331B (en) * 1977-08-01 1979-12-27 Massachusetts Gen Hospital Neuromuscular blocking agents
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
GB9015473D0 (en) * 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
JPH04112016A (ja) * 1990-09-03 1992-04-14 Fuji Electric Co Ltd トランスファ成形金型用プランジャ及びトランスファ成形装置
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
CA2284802C (en) * 1997-03-25 2009-06-16 Cornell Research Foundation, Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers

Also Published As

Publication number Publication date
EA002224B1 (ru) 2002-02-28
IS2346B (is) 2008-03-15
WO1998042674A1 (en) 1998-10-01
CN1257483A (zh) 2000-06-21
TR199902330T2 (xx) 2000-02-21
TW505635B (en) 2002-10-11
DE69819703T2 (de) 2004-09-30
EP0975599A1 (de) 2000-02-02
PL190860B1 (pl) 2006-02-28
HUP0001556A2 (hu) 2001-04-28
ATE295351T1 (de) 2005-05-15
DE69840816D1 (de) 2009-06-18
IL131918A0 (en) 2001-03-19
KR20010005621A (ko) 2001-01-15
JP4112015B2 (ja) 2008-07-02
EP0971898B1 (de) 2005-05-11
DE69830157T2 (de) 2006-05-11
ES2242275T3 (es) 2005-11-01
DK0975599T3 (da) 2004-03-15
WO1998042675A1 (en) 1998-10-01
MA26476A1 (fr) 2004-12-20
CA2284802C (en) 2009-06-16
NO314726B1 (no) 2003-05-12
AU6730598A (en) 1998-10-20
CZ340499A3 (cs) 2000-04-12
HU228230B1 (en) 2013-02-28
DE69830157D1 (de) 2005-06-16
PT975599E (pt) 2004-03-31
IS8717A (is) 2008-03-03
EP0975599B1 (de) 2003-11-12
EA199900756A1 (ru) 2000-08-28
BR9808422A (pt) 2000-05-23
HRP980157A2 (en) 1999-02-28
AP9901658A0 (en) 1999-09-30
AU745382B2 (en) 2002-03-21
AP1797A (en) 2007-11-15
RS49869B (sr) 2008-08-07
CA2284802A1 (en) 1998-10-01
JP2002503220A (ja) 2002-01-29
AU7521098A (en) 1998-10-20
IS5185A (is) 1999-09-17
NO994680D0 (no) 1999-09-24
PE68399A1 (es) 1999-07-23
NO994680L (no) 1999-11-24
SI0975599T1 (en) 2004-04-30
HRP980157B1 (en) 2004-10-31
EE04113B1 (et) 2003-08-15
JP4112016B2 (ja) 2008-07-02
EP0971898A1 (de) 2000-01-19
PL335885A1 (en) 2000-05-22
IL131918A (en) 2005-09-25
HUP0001556A3 (en) 2002-01-28
ATE254107T1 (de) 2003-11-15
EP1380573B1 (de) 2009-05-06
EP1526130A1 (de) 2005-04-27
MY121316A (en) 2006-01-28
DE69819703D1 (de) 2003-12-18
EP1380573A2 (de) 2004-01-14
US6177445B1 (en) 2001-01-23
BR9808422B1 (pt) 2010-08-24
EP1380573A3 (de) 2004-01-21
JP2008019272A (ja) 2008-01-31
AR012156A1 (es) 2000-09-27
US6187789B1 (en) 2001-02-13
CZ293786B6 (cs) 2004-07-14
EE9900424A (et) 2000-04-17
CO4940499A1 (es) 2000-07-24
ID22901A (id) 1999-12-16
PT971898E (pt) 2005-07-29
ES2210757T3 (es) 2004-07-01
NZ337797A (en) 2001-03-30
KR100554601B1 (ko) 2006-03-03
KR100578443B1 (ko) 2006-05-11
HK1023342A1 (en) 2000-09-08
JP2002517168A (ja) 2002-06-11
KR20050103984A (ko) 2005-11-01
YU48399A (sh) 2002-06-19
ATE430734T1 (de) 2009-05-15
UY24933A1 (es) 2000-12-29
CN1203061C (zh) 2005-05-25

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