DK0970957T3 - Diaza-spiro[3.5]nonan-derivativer - Google Patents

Diaza-spiro[3.5]nonan-derivativer

Info

Publication number
DK0970957T3
DK0970957T3 DK99110943T DK99110943T DK0970957T3 DK 0970957 T3 DK0970957 T3 DK 0970957T3 DK 99110943 T DK99110943 T DK 99110943T DK 99110943 T DK99110943 T DK 99110943T DK 0970957 T3 DK0970957 T3 DK 0970957T3
Authority
DK
Denmark
Prior art keywords
diazaspiro
nonane derivatives
nonane
derivatives
Prior art date
Application number
DK99110943T
Other languages
Danish (da)
English (en)
Inventor
Geo Adam
Andrea Cesura
Francois Jenck
Sabine Kolczewski
Stephan Roever
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0970957T3 publication Critical patent/DK0970957T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DK99110943T 1998-06-12 1999-06-07 Diaza-spiro[3.5]nonan-derivativer DK0970957T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (1)

Publication Number Publication Date
DK0970957T3 true DK0970957T3 (da) 2001-12-03

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99110943T DK0970957T3 (da) 1998-06-12 1999-06-07 Diaza-spiro[3.5]nonan-derivativer

Country Status (28)

Country Link
US (1) US6113527A (fr)
EP (1) EP0970957B1 (fr)
JP (1) JP3286268B2 (fr)
KR (1) KR100344732B1 (fr)
CN (1) CN1107066C (fr)
AR (1) AR019859A1 (fr)
AT (1) ATE204279T1 (fr)
AU (1) AU743983B2 (fr)
BR (1) BR9902651A (fr)
CA (1) CA2274202A1 (fr)
DE (1) DE69900220T2 (fr)
DK (1) DK0970957T3 (fr)
ES (1) ES2162503T3 (fr)
HR (1) HRP990188A2 (fr)
HU (1) HU220894B1 (fr)
ID (1) ID23304A (fr)
IL (1) IL130377A0 (fr)
MA (1) MA26644A1 (fr)
NO (1) NO312590B1 (fr)
NZ (1) NZ336189A (fr)
PE (1) PE20000548A1 (fr)
PL (1) PL333695A1 (fr)
PT (1) PT970957E (fr)
SG (1) SG79259A1 (fr)
SI (1) SI0970957T1 (fr)
TR (1) TR199901381A2 (fr)
YU (1) YU26499A (fr)
ZA (1) ZA993852B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004034A1 (fr) * 2001-07-02 2003-01-16 Omeros Corporation Procede visant a induire une analgesie, qui comprend l'administration alternee d'un agoniste de recepteur d'opioides et d'un agoniste de recepteur 1 du type recepteur d'opioides, et pompe a perfusion implantable
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
ES2392340T3 (es) * 2002-03-29 2012-12-07 Mitsubishi Tanabe Pharma Corporation Remedio para los trastornos del sueño
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
SI1519939T1 (sl) 2002-07-05 2010-04-30 Targacept Inc N-aril diazaspiracikliŽŤne spojine in postopki za njihovo pripravo in njihova uporaba
BR0306309A (pt) * 2002-09-09 2004-10-19 Janssen Pharmaceutica Nv Derivados de 1,3,8-triazaespiro[4.5]decan-4-ona substituìda com hidroxialquila úteis para o tratamento de distúrbios mediados pelo receptor orl-1
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
WO2005060947A2 (fr) * 2003-12-19 2005-07-07 Sri International Ligands agonistes et antagonistes du recepteur de la nociceptine
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
WO2006023630A2 (fr) * 2004-08-20 2006-03-02 Targacept, Inc. Utilisation de composes diazaspiracycliques n-aryle dans le traitement de la toxicomanie
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
CN101622254B (zh) * 2006-11-28 2013-05-29 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101679430B (zh) * 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
WO2023122662A1 (fr) * 2021-12-22 2023-06-29 The Regents Of The University Of California Inhibiteurs de liaison covalente des mutants g12s, g12d et/ou g12e de k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
NZ336189A (en) 2000-10-27
PL333695A1 (en) 1999-12-20
PE20000548A1 (es) 2000-07-15
HRP990188A2 (en) 2000-02-29
AU3498799A (en) 1999-12-23
HU9901911D0 (en) 1999-08-30
TR199901381A3 (tr) 2000-01-21
ZA993852B (en) 1999-12-13
DE69900220T2 (de) 2002-05-08
CN1242366A (zh) 2000-01-26
AR019859A1 (es) 2002-03-20
KR100344732B1 (ko) 2002-07-19
PT970957E (pt) 2002-02-28
TR199901381A2 (xx) 2000-01-21
SI0970957T1 (fr) 2001-12-31
JP2000053679A (ja) 2000-02-22
IL130377A0 (en) 2000-06-01
US6113527A (en) 2000-09-05
JP3286268B2 (ja) 2002-05-27
NO992873L (no) 1999-12-13
EP0970957B1 (fr) 2001-08-16
CA2274202A1 (fr) 1999-12-12
HU220894B1 (en) 2002-06-29
BR9902651A (pt) 2000-05-16
MA26644A1 (fr) 2004-12-20
ES2162503T3 (es) 2001-12-16
YU26499A (sh) 2002-09-19
NO312590B1 (no) 2002-06-03
EP0970957A1 (fr) 2000-01-12
NO992873D0 (no) 1999-06-11
HUP9901911A1 (hu) 2000-05-28
SG79259A1 (en) 2001-03-20
ID23304A (id) 2000-04-05
KR20000006060A (ko) 2000-01-25
AU743983B2 (en) 2002-02-14
ATE204279T1 (de) 2001-09-15
DE69900220D1 (de) 2001-09-20
CN1107066C (zh) 2003-04-30

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