DK0937068T3 - Fremgangsmåde til krystallisation af losartan - Google Patents

Fremgangsmåde til krystallisation af losartan

Info

Publication number
DK0937068T3
DK0937068T3 DK97913800T DK97913800T DK0937068T3 DK 0937068 T3 DK0937068 T3 DK 0937068T3 DK 97913800 T DK97913800 T DK 97913800T DK 97913800 T DK97913800 T DK 97913800T DK 0937068 T3 DK0937068 T3 DK 0937068T3
Authority
DK
Denmark
Prior art keywords
losartan
crystallization
Prior art date
Application number
DK97913800T
Other languages
Danish (da)
English (en)
Inventor
Patrick Breen
Erik A Dienemann
Albert D Epstein
Karen A Larson
Michael T Kennedy
Hari Mahadevan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625804.1A external-priority patent/GB9625804D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0937068T3 publication Critical patent/DK0937068T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DK97913800T 1996-10-29 1997-10-24 Fremgangsmåde til krystallisation af losartan DK0937068T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2932696P 1996-10-29 1996-10-29
GBGB9625804.1A GB9625804D0 (en) 1996-12-12 1996-12-12 Process for the crystallization of losartan
PCT/US1997/019442 WO1998018787A1 (en) 1996-10-29 1997-10-24 Process for the crystallization of losartan

Publications (1)

Publication Number Publication Date
DK0937068T3 true DK0937068T3 (da) 2002-05-21

Family

ID=26310606

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97913800T DK0937068T3 (da) 1996-10-29 1997-10-24 Fremgangsmåde til krystallisation af losartan

Country Status (18)

Country Link
US (1) US5859258A (hr)
EP (1) EP0937068B1 (hr)
JP (1) JP3249827B2 (hr)
CN (1) CN1101393C (hr)
AR (1) AR010256A1 (hr)
AT (1) ATE214388T1 (hr)
AU (1) AU5089898A (hr)
BR (1) BR9712390A (hr)
CZ (1) CZ291672B6 (hr)
DE (1) DE69711068T2 (hr)
DK (1) DK0937068T3 (hr)
EA (1) EA001046B1 (hr)
ES (1) ES2173433T3 (hr)
HR (1) HRP970565B1 (hr)
PT (1) PT937068E (hr)
SK (1) SK282875B6 (hr)
TW (1) TW411338B (hr)
WO (1) WO1998018787A1 (hr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
JP2002080354A (ja) * 2000-09-05 2002-03-19 Kao Corp 血圧降下剤組成物
BR0102252B1 (pt) * 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
SI21236A (sl) * 2001-05-18 2003-12-31 Aurobindo Pharma Limited Postopek kristalizacije losartan kalija
US7429238B2 (en) * 2001-10-15 2008-09-30 The Regents Of The University Of Michigan Systems and methods for the generation of crystalline polymorphs
CA2464561A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
EP1634880A3 (en) 2002-04-29 2006-04-12 Teva Pharmaceutical Industries Ltd. Processes for preparing losartan and losartan potassium
US20040097568A1 (en) * 2002-07-29 2004-05-20 Dr. Reddy's Laboratories Limited Crystalline form of losartan potassium
EP1471908B1 (en) * 2002-10-17 2007-08-08 Teva Pharmaceutical Industries Ltd. Process for preparing losartan potassium with improved flowability
US20060241305A1 (en) * 2002-10-31 2006-10-26 Yatendra Kumar Amorphous form of losartan potassium
WO2004066997A2 (en) * 2003-01-30 2004-08-12 Lek Pharmaceuticals D.D. Preparation of new pharmaceutically suitable salt of losartan and forms thereof with new purification and isolation methods
WO2004076442A1 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Polymorphs of losartan
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
ITMI20032472A1 (it) * 2003-12-16 2005-06-17 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di losartan potassio cristallino
WO2005066158A2 (en) * 2004-01-06 2005-07-21 Ipca Laboratories Limited An improved process for the synthesis of losartan potassium
BRPI0512379A (pt) * 2004-06-23 2008-03-11 Solvay Pharm Gmbh composições farmacêuticas compreendendo inibidores de nep, inibidores do sistema de produção de endotelina endógena e antagonista do receptor at1
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
ITMI20050551A1 (it) * 2005-04-01 2006-10-02 Dipharma Spa Forma cristallina alfa di losartan potassio
EP2081892A4 (en) 2006-11-17 2014-03-05 Donald F Weaver COMPOUNDS AND METHOD FOR THE TREATMENT OF PROTEIN DISAPPEARANCE
ES2315141B1 (es) * 2006-11-23 2009-12-22 Quimica Sintetica, S.A Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
DE69233208T2 (de) * 1991-11-18 2004-07-08 E.I. Du Pont De Nemours And Co., Wilmington Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
EP0736021A4 (en) * 1993-12-23 1997-04-02 Merck & Co Inc LOSARTANE POLYMORPHS AND PROCESS FOR THE PREPARATION OF FORM II OF LOSARTANE

Also Published As

Publication number Publication date
PT937068E (pt) 2002-07-31
JP2000504343A (ja) 2000-04-11
CN1101393C (zh) 2003-02-12
CN1241186A (zh) 2000-01-12
ATE214388T1 (de) 2002-03-15
EP0937068B1 (en) 2002-03-13
DE69711068T2 (de) 2002-09-12
DE69711068D1 (de) 2002-04-18
JP3249827B2 (ja) 2002-01-21
BR9712390A (pt) 1999-08-31
SK57099A3 (en) 2000-02-14
CZ151599A3 (cs) 1999-10-13
AU5089898A (en) 1998-05-22
EP0937068A1 (en) 1999-08-25
HRP970565B1 (en) 2003-02-28
US5859258A (en) 1999-01-12
EA199900427A1 (ru) 1999-10-28
CZ291672B6 (cs) 2003-04-16
SK282875B6 (sk) 2003-01-09
AR010256A1 (es) 2000-06-07
TW411338B (en) 2000-11-11
HRP970565A2 (en) 1998-08-31
WO1998018787A1 (en) 1998-05-07
ES2173433T3 (es) 2002-10-16
EA001046B1 (ru) 2000-08-28

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