DK0934301T3 - Aminothiophencarboxylsyreamider og anvendelse deraf som phosphodiesteraseinhibitorer - Google Patents

Aminothiophencarboxylsyreamider og anvendelse deraf som phosphodiesteraseinhibitorer

Info

Publication number
DK0934301T3
DK0934301T3 DK97912140T DK97912140T DK0934301T3 DK 0934301 T3 DK0934301 T3 DK 0934301T3 DK 97912140 T DK97912140 T DK 97912140T DK 97912140 T DK97912140 T DK 97912140T DK 0934301 T3 DK0934301 T3 DK 0934301T3
Authority
DK
Denmark
Prior art keywords
acid amides
phosphodiesterase inhibitors
aminothiophenecarboxylic
aminothiophenecarboxylic acid
phosphodiesterase
Prior art date
Application number
DK97912140T
Other languages
Danish (da)
English (en)
Inventor
Rochus Jonas
Pierre Schelling
Franz-Werner Kluxen
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0934301T3 publication Critical patent/DK0934301T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97912140T 1996-10-15 1997-10-08 Aminothiophencarboxylsyreamider og anvendelse deraf som phosphodiesteraseinhibitorer DK0934301T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19642451A DE19642451A1 (de) 1996-10-15 1996-10-15 Aminothiophencarbonsäureamide
PCT/EP1997/005531 WO1998016521A1 (de) 1996-10-15 1997-10-08 Aminothiophencarbonsäureamide und ihre verwendung als phosphodiesterase inhibitoren

Publications (1)

Publication Number Publication Date
DK0934301T3 true DK0934301T3 (da) 2001-10-08

Family

ID=7808775

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97912140T DK0934301T3 (da) 1996-10-15 1997-10-08 Aminothiophencarboxylsyreamider og anvendelse deraf som phosphodiesteraseinhibitorer

Country Status (26)

Country Link
US (1) US6143777A (ko)
EP (1) EP0934301B1 (ko)
JP (1) JP4243352B2 (ko)
KR (1) KR100479811B1 (ko)
CN (1) CN1110493C (ko)
AR (1) AR009985A1 (ko)
AT (1) ATE202347T1 (ko)
AU (1) AU725741B2 (ko)
BR (1) BR9712321A (ko)
CA (1) CA2268886C (ko)
CZ (1) CZ297253B6 (ko)
DE (2) DE19642451A1 (ko)
DK (1) DK0934301T3 (ko)
ES (1) ES2159851T3 (ko)
GR (1) GR3036341T3 (ko)
HK (1) HK1020724A1 (ko)
HU (1) HUP9904703A3 (ko)
NO (1) NO991776L (ko)
PL (1) PL192109B1 (ko)
PT (1) PT934301E (ko)
RU (1) RU2184731C2 (ko)
SI (1) SI0934301T1 (ko)
SK (1) SK283807B6 (ko)
TW (1) TW438791B (ko)
WO (1) WO1998016521A1 (ko)
ZA (1) ZA979199B (ko)

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US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7196207B2 (en) * 2002-07-24 2007-03-27 Mitsui Chemicals, Inc. Method for producing 2-alkyl-3-aminothiophene derivative
US7179836B2 (en) * 2002-09-20 2007-02-20 Smithkline Beecham Corporation Chemical compounds
FR2875807B1 (fr) 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TWI392673B (zh) * 2008-08-27 2013-04-11 Calcimedica Inc 調控細胞內鈣離子濃度之化合物
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
RU2503671C1 (ru) * 2012-07-31 2014-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" (Z)-2-[(3-КАРБАМОИЛ-4,5,6,7-ТЕТРАГИДРОБЕНЗО[b]ТИЕН-2-ИЛ)АМИНО]-4-(4-R-ФЕНИЛ)-4-ОКСОБУТ-2-ЕНОВЫЕ КИСЛОТЫ, ОБЛАДАЮЩИЕ АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТЬЮ
RU2501795C1 (ru) * 2012-10-01 2013-12-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" N-R-АМИДЫ (Z)-2[(3-ЭТОКСИКАРБОНИЛ)-4,5,6,7-ТЕТРАГИДРОБЕНЗО[b]ТИЕН-2-ИЛ)АМИНО]-4-ФЕНИЛ-4-ОКСОБУТ-2-ЕНОВЫХ КИСЛОТ, ОБЛАДАЮЩИЕ АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТЬЮ
JP6687550B2 (ja) 2014-06-23 2020-04-22 セルジーン コーポレイション 肝疾患又は肝機能異常を治療するためのアプレミラスト
RU2722176C1 (ru) * 2019-09-06 2020-05-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (z)-2((4-r1-5-r2-3-(этоксикарбонил)тиофен-2-ил)амино)-4-оксо-4-r3-бут-2-еновые кислоты, обладающие противомикробной активностью

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Also Published As

Publication number Publication date
AU725741B2 (en) 2000-10-19
BR9712321A (pt) 1999-08-31
HUP9904703A2 (hu) 2001-05-28
DE59703869D1 (de) 2001-07-26
CA2268886A1 (en) 1998-04-23
RU2184731C2 (ru) 2002-07-10
SK283807B6 (sk) 2004-02-03
TW438791B (en) 2001-06-07
AR009985A1 (es) 2000-05-17
PL192109B1 (pl) 2006-08-31
US6143777A (en) 2000-11-07
CN1110493C (zh) 2003-06-04
PT934301E (pt) 2001-10-31
CZ297253B6 (cs) 2006-10-11
PL332802A1 (en) 1999-10-11
WO1998016521A1 (de) 1998-04-23
NO991776D0 (no) 1999-04-14
EP0934301B1 (de) 2001-06-20
ATE202347T1 (de) 2001-07-15
HUP9904703A3 (en) 2001-06-28
DE19642451A1 (de) 1998-04-16
NO991776L (no) 1999-06-09
KR20000049154A (ko) 2000-07-25
AU4945197A (en) 1998-05-11
SI0934301T1 (en) 2001-12-31
ZA979199B (en) 1998-05-11
JP4243352B2 (ja) 2009-03-25
JP2001501957A (ja) 2001-02-13
GR3036341T3 (en) 2001-11-30
CA2268886C (en) 2008-05-20
ES2159851T3 (es) 2001-10-16
KR100479811B1 (ko) 2005-03-30
HK1020724A1 (en) 2000-05-19
CN1233246A (zh) 1999-10-27
SK43299A3 (en) 2000-04-10
CZ124099A3 (cs) 1999-07-14
EP0934301A1 (de) 1999-08-11

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