DK0929567T3 - Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese - Google Patents

Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese

Info

Publication number
DK0929567T3
DK0929567T3 DK97939974T DK97939974T DK0929567T3 DK 0929567 T3 DK0929567 T3 DK 0929567T3 DK 97939974 T DK97939974 T DK 97939974T DK 97939974 T DK97939974 T DK 97939974T DK 0929567 T3 DK0929567 T3 DK 0929567T3
Authority
DK
Denmark
Prior art keywords
synthesis
phase peptide
solid phase
enhanced solid
peptide synthesis
Prior art date
Application number
DK97939974T
Other languages
Danish (da)
English (en)
Inventor
Arne Holm
Bjarne Due Larsen
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Application granted granted Critical
Publication of DK0929567T3 publication Critical patent/DK0929567T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
DK97939974T 1996-09-09 1997-09-09 Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese DK0929567T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK97196 1996-09-09
PCT/DK1997/000375 WO1998011125A1 (en) 1996-09-09 1997-09-09 Improved solid-phase peptide synthesis and agent for use in such synthesis
EP97939974A EP0929567B1 (en) 1996-09-09 1997-09-09 Solid-phase peptide synthesis

Publications (1)

Publication Number Publication Date
DK0929567T3 true DK0929567T3 (da) 2005-06-27

Family

ID=8099561

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97939974T DK0929567T3 (da) 1996-09-09 1997-09-09 Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese

Country Status (14)

Country Link
US (1) US7348404B2 (cs)
EP (1) EP0929567B1 (cs)
JP (1) JP4405594B2 (cs)
AT (1) ATE290014T1 (cs)
AU (1) AU723268B2 (cs)
CA (1) CA2265900C (cs)
CZ (1) CZ295838B6 (cs)
DE (1) DE69732640T2 (cs)
DK (1) DK0929567T3 (cs)
ES (1) ES2239364T3 (cs)
HU (1) HU230354B1 (cs)
IL (1) IL128829A (cs)
PT (1) PT929567E (cs)
WO (1) WO1998011125A1 (cs)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1950223A3 (en) * 1998-03-09 2009-05-13 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
US7550425B2 (en) 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
EP2295451A1 (en) 2005-05-04 2011-03-16 Zealand Pharma A/S Glucagon-like-peptide (GLP-2) analogues
GB0514071D0 (en) 2005-07-07 2005-08-17 Zealand Pharma As N- or C- terminally modified small peptides
EP1975142A4 (en) * 2005-11-22 2009-12-02 Univ Nihon AUTOMATED SOLID PHASE SYNTHESIS OF PYRROL-IMIDAZOLE POLYAMIDE
PL1966130T3 (pl) 2005-12-23 2014-05-30 Zealand Pharma As Zmodyfikowane związki mimetyczne lizyny
US20100168034A1 (en) * 2006-02-20 2010-07-01 Ewha University-Industry Collaboration Foundation Peptide having cell membrane penetrating activity
DK2000474T3 (en) * 2006-03-29 2018-01-22 Glytech Inc PROCEDURE FOR PRODUCING A PEPTID THIOESTER COMPOUND
BRPI0718566A2 (pt) 2006-11-08 2014-03-11 Zealand Pharma As Peptídeo, análogo do mesmo, composição farmacêutica, usos de um análogo de peptídeo, e de uma molécula de ácido nucléico, de um vetor de expressão, ou de uma célula hospedeira, molécula de ácido nucléico, vetor de expressão, célula hospedeira, métodos para produzir o análogo de peptídeo-2 tipo-glucagon (glp-2), e, kit terapêutico.
WO2008152403A1 (en) 2007-06-15 2008-12-18 Zealand Pharma A/S Glucagon analogues
CN102292348B (zh) 2008-12-15 2015-07-08 西兰制药公司 胰高血糖素类似物
ES2439499T3 (es) 2008-12-15 2014-01-23 Zealand Pharma A/S Análogos de glucagón
MY160219A (en) 2008-12-15 2017-02-28 Zealand Pharma As Glucagon analogues
AU2008365556A1 (en) 2008-12-15 2011-07-21 Zealand Pharma A/S Glucagon analogues
SI2454282T1 (sl) 2009-07-13 2015-06-30 Zealand Pharma A/S Acilirani glukagonski analogi
AU2011247452B2 (en) 2010-04-27 2016-03-17 Zealand Pharma A/S Peptide conjugates of GLP-1 receptor agonists and gastrin and their use
AR081975A1 (es) 2010-06-23 2012-10-31 Zealand Pharma As Analogos de glucagon
JP6023048B2 (ja) 2010-06-24 2016-11-09 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
TW201247702A (en) 2011-01-20 2012-12-01 Zealand Pharma As Use of acylated glucagon analogues
CN104144704B (zh) 2011-11-03 2018-03-23 西兰制药公司 Glp‑1受体激动剂肽胃泌素缀合物
WO2013092703A2 (en) 2011-12-23 2013-06-27 Zealand Pharma A/S Glucagon analogues
WO2013098408A1 (en) 2011-12-30 2013-07-04 Zealand Pharma A/S Glucagon and cck receptor agonist peptide conjugates
EP2809339A2 (en) 2012-02-03 2014-12-10 Zealand Pharma A/S Ghrelin analogues
US9453064B2 (en) 2012-05-03 2016-09-27 Zealand Pharma A/S Glucagon-like-peptide-2 (GLP-2) analogues
HK1208232A1 (en) 2012-05-03 2016-02-26 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
US10442847B2 (en) 2012-07-23 2019-10-15 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
SI2970487T1 (sl) 2013-03-12 2020-07-31 Molecular Templates, Inc. Citotoksični proteini, ki obsegajo celico-ciljajoče vezavne regije in podenotske regije Shiga toksina A, za selektivno ubijanje specifičnih celičnih tipov
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
SG11201506885UA (en) 2013-03-21 2015-09-29 Sanofi Aventis Deutschland Synthesis of cyclic imide containing peptide products
CN119119235A (zh) 2013-10-17 2024-12-13 西兰制药公司 酰化胰高血糖素类似物
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
CN105849122B (zh) 2013-11-06 2021-04-30 西兰制药公司 Gip-glp-1双重激动剂化合物及方法
KR102310392B1 (ko) 2013-11-06 2021-10-13 질랜드 파마 에이/에스 글루카곤-glp-1-gip 삼원 효능제 화합물
WO2015100246A1 (en) 2013-12-24 2015-07-02 Ossianix, Inc. Baff selective binding compounds and related methods
KR102514910B1 (ko) 2014-01-27 2023-03-29 몰레큘러 템플레이츠, 인코퍼레이션. 폴리펩티드를 전달하는 mhc 클래스 i 항원결정기
JP6935195B2 (ja) 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素aサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
PT3604333T (pt) 2014-03-11 2021-06-07 Molecular Templates Inc Proteínas compreendendo regiões efetoras da subunidade a da toxina shiga próximas de amino-terminais e regiões de ligação do tipo imunoglobulina de direcionamento celular capazes de se ligarem especificamente a cd38
JP6735237B2 (ja) 2014-06-11 2020-08-05 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. プロテアーゼ切断耐性、志賀毒素aサブユニットエフェクターポリペプチド及びそれを含む細胞標的化分子
CA2953569A1 (en) 2014-06-26 2015-12-30 Ossianix, Inc. Semi-synthetic nurse shark vnar libraries for making and using selective binding compounds
TWI705973B (zh) 2014-10-29 2020-10-01 丹麥商西蘭製藥公司 Gip促效劑化合物及方法
CA2967830A1 (en) 2014-11-14 2016-05-19 Ossianix, Inc. Tfr selective binding compounds and related methods
WO2016126950A1 (en) 2015-02-05 2016-08-11 Molecular Templates, Inc. Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
EP3271381B1 (en) 2015-03-18 2021-09-08 Zealand Pharma A/S Amylin analogues
GB201506380D0 (en) 2015-04-15 2015-05-27 Serodus Asa Materials and methods for treatment of pulmonary hypertension
BR112017022009A2 (pt) 2015-04-16 2018-07-03 Zealand Pharma A/S ?composto, método de produção e síntese do mesmo e seu uso, composição e conjunto terapêutico?
LT3303373T (lt) 2015-05-30 2020-07-10 Molecular Templates, Inc. Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės
MX2018001208A (es) 2015-07-26 2018-03-26 Molecular Templates Inc Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.
EP3350197A4 (en) 2015-09-17 2019-04-24 Massachusetts Institute of Technology PROCESS AND SYSTEMS FOR SOLID PHASE PEPTIDE SYNTHESIS
EP3494216B1 (en) 2016-08-06 2025-10-15 Ossianix, Inc. In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use
TWI784968B (zh) 2016-09-09 2022-12-01 丹麥商西蘭製藥公司 澱粉素類似物
WO2018104560A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Glp-1/glp-2 dual agonists
WO2018104558A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
WO2018104559A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Glp-1/glp-2 dual agonists
WO2018103868A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
DK3551651T3 (da) 2016-12-09 2024-05-13 Zealand Pharma As Acylerede glp-1/glp-2-dobbeltagonister
KR102590672B1 (ko) 2017-01-25 2023-10-18 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
IL271245B2 (en) 2017-06-16 2023-10-01 Zealand Pharma As Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues
WO2019089395A1 (en) 2017-11-02 2019-05-09 Ossianix, Inc. Improved tfr-selective binding peptides capable of crossing the blood brain barrier
SG11202008177WA (en) 2018-02-27 2020-09-29 Zp Spv 3 K/S Compstatin analogues and their medical uses
MX2019009726A (es) 2018-04-17 2020-02-05 Molecular Templates Inc Moleculas con direccion hacia her2 que comprenden andamiajes de la sub-unidad a de la toxina shiga desinmunizados.
US12258414B2 (en) 2018-06-22 2025-03-25 Ossianix, Inc. Anti-CD98hc VNARs for crossing the blood brain barrier and type IV VNAR libraries
KR20210052389A (ko) 2018-08-27 2021-05-10 리제너론 파마슈티칼스 인코포레이티드 다운스트림 정제에서의 라만 분광법의 사용
US12351642B2 (en) 2018-09-14 2025-07-08 Ossianix, Inc. TFR-specific binding moieties and transcytosis method to select VNARs that cross cellular barriers
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
EP3914358A1 (en) 2019-01-23 2021-12-01 Millennium Pharmaceuticals, Inc. Anti-cd38 antibodies
US11713347B2 (en) 2019-01-23 2023-08-01 Millennium Pharmaceuticals, Inc. CD38-binding proteins comprising de-immunized Shiga toxin A subunit effectors
US20220202704A1 (en) 2019-06-14 2022-06-30 Zealand Pharma A/S Pharmaceutical parenteral composition of dual glp1/2 agonist
KR20220066287A (ko) 2019-08-27 2022-05-24 제트피 에스피브이 3 케이/에스 콤프스타틴 유사체 및 이의 의약 용도
US11918649B2 (en) 2019-09-18 2024-03-05 Molecular Templates, Inc. PD-L1-binding molecules comprising Shiga toxin a subunit scaffolds
TW202116350A (zh) 2019-09-20 2021-05-01 丹麥商西蘭製藥公司 Kv1.3阻斷劑
US20210155671A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents
WO2021198195A1 (en) 2020-03-30 2021-10-07 Zealand Pharma A/S Agonist combination
EP4126003A1 (en) 2020-03-30 2023-02-08 Zealand Pharma A/S Glp-1/glp-2 dual agonists
MX2023000679A (es) 2020-07-16 2023-04-18 Zp Spv 3 K/S Inhibidores del factor c3 del complemento y sus usos medicos.
WO2022103769A1 (en) 2020-11-11 2022-05-19 Ossianix, Inc. High affinity human and monkey specific tfr-1 vnars
US20240024425A1 (en) 2020-12-16 2024-01-25 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
AU2021399904B2 (en) 2020-12-16 2024-09-05 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
EP4262746A1 (en) 2020-12-16 2023-10-25 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
EP4294424A1 (en) 2021-02-18 2023-12-27 Zealand Pharma A/S Composition for treating short bowel syndrome
CA3213295A1 (en) 2021-03-17 2022-09-22 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
WO2022200374A1 (en) 2021-03-23 2022-09-29 Zealand Pharma A/S Kv1.3 blockers
WO2022260877A1 (en) 2021-06-07 2022-12-15 Ossianix, Inc. Shark vnars for treating covid-19
KR20240022551A (ko) 2021-06-18 2024-02-20 베이징 투오 지에 바이오파마수티컬 컴퍼니 리미티드 글루카곤 유사체 및 이의 의학적 용도
US20250122298A1 (en) 2021-08-17 2025-04-17 Ossianix, Inc. Deimmunized vnar domains and scaffolds
WO2023031380A1 (en) 2021-09-03 2023-03-09 Zealand Pharma A/S Dosage regime
EP4440592A1 (en) 2021-12-01 2024-10-09 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2024068848A1 (en) 2022-09-28 2024-04-04 Zealand Pharma A/S Methods for treating obesity
JP2025534884A (ja) 2022-10-18 2025-10-20 ジーランド ファーマ エー/エス 阻害剤
WO2024168411A1 (pt) * 2023-02-15 2024-08-22 Proteimax Bio Technology Israel Ltd Aditivo de alimento e/ou suplemento alimentar, processo de obtenção, formulação de alimento funcional e/ou suplemento alimentar, uso
EP4471048A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
EP4471049A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2025056677A1 (en) 2023-09-15 2025-03-20 Zealand Pharma A/S Dasiglucagon for use in the treatment of congenital hyperinsulinism
WO2025120001A1 (en) 2023-12-04 2025-06-12 Zealand Pharma A/S Amylin analogues for reducing consumption of high-fat food
WO2025120002A1 (en) 2023-12-04 2025-06-12 Zealand Pharma A/S Petrelintide for reducing weight whilst preserving lean mass

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116666A (cs) * 1974-07-30 1976-02-10 Shionogi Seiyaku Kk
US5021550A (en) * 1986-10-07 1991-06-04 Thomas Jefferson University Method for preventing deletion sequences in solid phase synthesis
JP2807287B2 (ja) * 1989-10-13 1998-10-08 株式会社医学生物学研究所 ペプチドおよびその用途
JP3929484B2 (ja) * 1993-09-14 2007-06-13 ジェネンテック・インコーポレーテッド エコチンおよびその同族体を含む医薬的組成物
US7176282B1 (en) * 1996-09-09 2007-02-13 Zealand Pharma A/S Solid-phase peptide synthesis and agent for use in such synthesis
EP1950223A3 (en) * 1998-03-09 2009-05-13 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis

Also Published As

Publication number Publication date
CA2265900C (en) 2007-07-31
CZ295838B6 (cs) 2005-11-16
EP0929567A1 (en) 1999-07-21
DE69732640T2 (de) 2006-01-12
HU230354B1 (hu) 2016-02-29
HUP0102900A3 (en) 2002-02-28
PT929567E (pt) 2005-07-29
IL128829A0 (en) 2000-01-31
ES2239364T3 (es) 2005-09-16
JP4405594B2 (ja) 2010-01-27
ATE290014T1 (de) 2005-03-15
JP2001500134A (ja) 2001-01-09
US7348404B2 (en) 2008-03-25
CA2265900A1 (en) 1998-03-19
CZ80399A3 (cs) 1999-08-11
IL128829A (en) 2005-08-31
DE69732640D1 (de) 2005-04-07
EP0929567B1 (en) 2005-03-02
US20070004905A1 (en) 2007-01-04
AU4199397A (en) 1998-04-02
WO1998011125A1 (en) 1998-03-19
AU723268B2 (en) 2000-08-24
HUP0102900A2 (hu) 2002-01-28

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