DK0918776T3 - Totalsyntese af antitumor acylfulvener - Google Patents

Totalsyntese af antitumor acylfulvener

Info

Publication number
DK0918776T3
DK0918776T3 DK97934366T DK97934366T DK0918776T3 DK 0918776 T3 DK0918776 T3 DK 0918776T3 DK 97934366 T DK97934366 T DK 97934366T DK 97934366 T DK97934366 T DK 97934366T DK 0918776 T3 DK0918776 T3 DK 0918776T3
Authority
DK
Denmark
Prior art keywords
acylfulvenes
antitumor
total synthesis
synthesis
total
Prior art date
Application number
DK97934366T
Other languages
Danish (da)
English (en)
Inventor
Trevor C Mcmorris
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK0918776T3 publication Critical patent/DK0918776T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/37—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/737—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
DK97934366T 1996-08-08 1997-08-05 Totalsyntese af antitumor acylfulvener DK0918776T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/689,461 US5723632A (en) 1996-08-08 1996-08-08 Total synthesis of antitumor acylfulvenes

Publications (1)

Publication Number Publication Date
DK0918776T3 true DK0918776T3 (da) 2004-07-12

Family

ID=24768581

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97934366T DK0918776T3 (da) 1996-08-08 1997-08-05 Totalsyntese af antitumor acylfulvener

Country Status (12)

Country Link
US (6) US5723632A (US06252093-20010626-C00021.png)
EP (2) EP0918776B1 (US06252093-20010626-C00021.png)
JP (1) JP4267702B2 (US06252093-20010626-C00021.png)
AT (1) ATE263771T1 (US06252093-20010626-C00021.png)
AU (1) AU3744397A (US06252093-20010626-C00021.png)
CA (1) CA2262648A1 (US06252093-20010626-C00021.png)
DE (1) DE69728544T2 (US06252093-20010626-C00021.png)
DK (1) DK0918776T3 (US06252093-20010626-C00021.png)
ES (1) ES2215234T3 (US06252093-20010626-C00021.png)
HK (1) HK1019878A1 (US06252093-20010626-C00021.png)
PT (1) PT918776E (US06252093-20010626-C00021.png)
WO (1) WO1998005669A1 (US06252093-20010626-C00021.png)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6025328A (en) * 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents
US6635490B1 (en) * 2000-05-25 2003-10-21 Noble Laboratories Procedure for the simultaneous quantitative and qualitative analysis of both flavonoid glycosides and steroidal glycosides
EP1330459B1 (en) * 2000-10-02 2006-08-02 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
US7015247B2 (en) * 2000-10-12 2006-03-21 Alvin Guttag Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs
US6436916B1 (en) 2000-10-12 2002-08-20 Alvin Guttag Ibuprofen-aspirin and hydroxymethylacylfulvene analogs
ATE487744T1 (de) * 2001-06-22 2010-11-15 Borealis Tech Oy Metallocenkatalysatoren mit einer in 4-, 5-, 6- oder 7-stellung mit siloxy oder germyloxy substitutierten indenylgruppe
US7718385B2 (en) * 2003-10-17 2010-05-18 The Johns Hopkins University Bioactivation of alkylating agents for cancer treatment
ATE527998T1 (de) * 2005-08-03 2011-10-15 Univ California Illudin-analoga als krebsmittel
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
CA2685726A1 (en) * 2007-05-03 2008-11-13 Emory University Fulvene and fulvalene analogs and their use in treating cancers
GB0715576D0 (en) * 2007-08-09 2007-09-19 Syngenta Ltd Novel herbicides
WO2009089285A2 (en) * 2008-01-07 2009-07-16 Emory University Branched diepoxide compounds for the treatment of inflammatory disorders
US10285955B2 (en) 2014-04-10 2019-05-14 Af Chemicals, Llc Affinity medicant conjugate
US11135182B2 (en) 2014-04-10 2021-10-05 Af Chemicals, Llc Affinity medicant conjugates
JP2017518359A (ja) 2014-04-10 2017-07-06 エイエフ ケミカルス, エルエルシーAf Chemicals, Llc 親和性薬物コンジュゲート
CN104650160A (zh) * 2015-01-13 2015-05-27 济南大学 卡培他滨关键中间体1,2,3-o-三乙酰基-5-脱氧-d-核糖的合成新方法
BR112021006710A2 (pt) 2018-09-04 2021-08-10 Lantern Pharma Inc. composto análogos de iludina, usos dos mesmos e métodos para sintetizar os mesmos
EP3667323A1 (en) 2018-12-11 2020-06-17 Kelner, Michael Methods, compositions and devices for treating cancer with illudofulvenes
US11591295B2 (en) 2019-11-25 2023-02-28 Af Chemicals Llc Affinity illudofulvene conjugates

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) * 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
JPS62234040A (ja) * 1986-04-02 1987-10-14 Kyowa Hakko Kogyo Co Ltd Ｄｃ１０４３物質
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JPH05503077A (ja) * 1989-10-03 1993-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗腫瘍剤としてのイルージンアナログ
US5439936A (en) * 1989-10-03 1995-08-08 The Regents Of The University Of California Method of treating certain tumors using illudin analogs
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
KR100331667B1 (ko) * 1993-04-27 2002-11-08 스미스클라인 비참 코포레이션 엔도텔린수용체길항제
US5708163A (en) * 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
US6303120B1 (en) * 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US6025328A (en) 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents

Also Published As

Publication number Publication date
DE69728544T2 (de) 2004-09-16
US6717017B2 (en) 2004-04-06
US6469184B2 (en) 2002-10-22
US5856580A (en) 1999-01-05
US6252093B1 (en) 2001-06-26
ES2215234T3 (es) 2004-10-01
WO1998005669A1 (en) 1998-02-12
ATE263771T1 (de) 2004-04-15
US5723632A (en) 1998-03-03
CA2262648A1 (en) 1998-02-12
AU3744397A (en) 1998-02-25
EP1454890A2 (en) 2004-09-08
US20010029303A1 (en) 2001-10-11
EP0918776B1 (en) 2004-04-07
PT918776E (pt) 2004-07-30
HK1019878A1 (en) 2000-03-03
EP0918776A1 (en) 1999-06-02
US20030050495A1 (en) 2003-03-13
JP2000515552A (ja) 2000-11-21
DE69728544D1 (de) 2004-05-13
EP1454890A3 (en) 2004-11-10
JP4267702B2 (ja) 2009-05-27
US6160184A (en) 2000-12-12
EP1454890A8 (en) 2004-11-03

Similar Documents

Publication Publication Date Title
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
BE2018C008I2 (US06252093-20010626-C00021.png)
HK1001963A1 (en) Use of compounds in the preparation of a medicament for the inhibition of a pathological condition
DE69811117D1 (de) Tetrahydrothiopyran-phenyloxazolidinon-s-oxide
PE34996A1 (es) Nuevo derivado de pirrocarbazol
ATE232528T1 (de) Pyrimidinylpyrazolderivate
ATE248814T1 (de) 16-ene-vitamin d derivate
DE69612967D1 (en) Optisch aktive thiazolidinonderivate
DK0850646T3 (da) Liposompræparater af indolocarbazol-derivater
MY130817A (en) Herbicides
DK0963998T3 (da) Azasteroidforbindelse til behandling eller prævention af prostatacancer
CA2419463A1 (en) Primary intermediates for oxidative coloration of hair
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
DE69615814D1 (de) Uch-15-verbindungen