DK0909312T3 - Fremgangsmåde til fremstilling af polypeptider - Google Patents

Fremgangsmåde til fremstilling af polypeptider

Info

Publication number
DK0909312T3
DK0909312T3 DK97928141T DK97928141T DK0909312T3 DK 0909312 T3 DK0909312 T3 DK 0909312T3 DK 97928141 T DK97928141 T DK 97928141T DK 97928141 T DK97928141 T DK 97928141T DK 0909312 T3 DK0909312 T3 DK 0909312T3
Authority
DK
Denmark
Prior art keywords
yeast cells
glucagon
genetically modified
short chain
polypeptides
Prior art date
Application number
DK97928141T
Other languages
Danish (da)
English (en)
Inventor
Michi Egel-Mitani
Jakob Brandt
Knud Vad
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK0909312T3 publication Critical patent/DK0909312T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK97928141T 1996-07-05 1997-07-04 Fremgangsmåde til fremstilling af polypeptider DK0909312T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK74996 1996-07-05
PCT/DK1997/000298 WO1998001535A1 (en) 1996-07-05 1997-07-04 Method for the production of polypeptides

Publications (1)

Publication Number Publication Date
DK0909312T3 true DK0909312T3 (da) 2003-03-17

Family

ID=8097103

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97928141T DK0909312T3 (da) 1996-07-05 1997-07-04 Fremgangsmåde til fremstilling af polypeptider

Country Status (11)

Country Link
EP (1) EP0909312B1 (es)
JP (1) JP3998717B2 (es)
CN (1) CN1150313C (es)
AT (1) ATE229068T1 (es)
AU (1) AU3255497A (es)
CA (1) CA2258307C (es)
DE (1) DE69717629T2 (es)
DK (1) DK0909312T3 (es)
ES (1) ES2187782T3 (es)
IL (1) IL127583A0 (es)
WO (1) WO1998001535A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891669A (en) * 1997-03-17 1999-04-06 Novo Nordisk A/S, Novoalle, Methods for producing polypeptides in respiratory-deficient cells
AU2241699A (en) * 1998-01-27 1999-08-09 Board Of Regents Of The University And Community College System Of Nevada, The Expression of proteolytically-sensitive peptides
US6190883B1 (en) 1998-09-09 2001-02-20 Novo Nordisk A/S Method for the production of heterologous polypeptides in transformed yeast cells
US7371721B2 (en) 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
EP1970072A1 (en) 2000-09-18 2008-09-17 Sanos Bioscience A/S Use of GLP-2 peptides for the treatment of hyperparathyroidism
US7595172B2 (en) 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
AU2003237061A1 (en) * 2002-06-29 2004-01-19 Bioholdings Co., Ltd Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
JP2007532096A (ja) 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ アシル化されたインスリンの製造方法
WO2007020256A1 (en) 2005-08-16 2007-02-22 Novo Nordisk A/S Method for making mature insulin polypeptides
WO2007148345A2 (en) 2006-06-21 2007-12-27 Biocon Limited A method of producing biologically active polypeptide having insulinotropic activity
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
KR101812400B1 (ko) 2007-04-03 2017-12-27 옥시레인 유케이 리미티드 분자의 글리코실화
KR101005821B1 (ko) * 2007-12-28 2011-01-05 (주)바이오버드 배트록소빈의 변이 뉴클레오타이드 서열, α－인자 분비 시그널 서열 변이체 및 이를 이용한 재조합 단백질의 제조방법및 이를 이용한 배트록소빈의 제조방법
US9598682B2 (en) 2009-09-29 2017-03-21 Vib Vzw Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
JP2013511272A (ja) 2009-11-19 2013-04-04 オキシレイン ユーケー リミテッド 哺乳類様複合ｎ−グリカンを生成する酵母株
WO2011064282A1 (en) * 2009-11-25 2011-06-03 Novo Nordisk A/S Method for making polypeptides
JP6151183B2 (ja) 2010-09-29 2017-06-21 オキシレイン ユーケー リミテッド マンノース−１−ホスホ−６−マンノース結合からキャップを外すことおよびリン酸化ｎ−グリカンを脱マンノシル化することができるマンノシダーゼならびに哺乳動物細胞による糖タンパク質の取り込みを促進する方法
WO2012042387A2 (en) 2010-09-29 2012-04-05 Oxyrane Uk Limited De-mannosylation of phosphorylated n-glycans
CA2859303A1 (en) * 2011-12-30 2013-07-04 Oxyrane Uk Limited Methods and materials for reducing degradation of recombinant proteins
KR20190114003A (ko) 2012-03-15 2019-10-08 옥시레인 유케이 리미티드 폼페병의 치료를 위한 방법 및 물질
WO2014138371A1 (en) * 2013-03-06 2014-09-12 Glaxosmithkline Llc Host cells and methods of use
EP3110834B1 (en) * 2014-02-28 2018-11-07 Novo Nordisk A/S Mating factor alpha pro-peptide variants
JP7487951B2 (ja) * 2019-02-24 2024-05-21 オンコシミス バイオテック プライベート リミテッド 細菌による組換えｇｌｐ－１ペプチドの連続生産方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404270D0 (en) * 1994-03-05 1994-04-20 Delta Biotechnology Ltd Yeast strains and modified albumins

Also Published As

Publication number Publication date
JP3998717B2 (ja) 2007-10-31
DE69717629D1 (de) 2003-01-16
JP2000513941A (ja) 2000-10-24
EP0909312B1 (en) 2002-12-04
CA2258307A1 (en) 1998-01-15
IL127583A0 (en) 1999-10-28
AU3255497A (en) 1998-02-02
CN1225126A (zh) 1999-08-04
ATE229068T1 (de) 2002-12-15
EP0909312A1 (en) 1999-04-21
DE69717629T2 (de) 2003-09-11
WO1998001535A1 (en) 1998-01-15
CA2258307C (en) 2008-02-12
CN1150313C (zh) 2004-05-19
ES2187782T3 (es) 2003-06-16

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