DK0408764T3 - Fremgangsmåde til fremstilling af alfa-amiderede peptider - Google Patents

Fremgangsmåde til fremstilling af alfa-amiderede peptider

Info

Publication number
DK0408764T3
DK0408764T3 DK90901896.2T DK90901896T DK0408764T3 DK 0408764 T3 DK0408764 T3 DK 0408764T3 DK 90901896 T DK90901896 T DK 90901896T DK 0408764 T3 DK0408764 T3 DK 0408764T3
Authority
DK
Denmark
Prior art keywords
peptide
gly
formula
protein
amino acid
Prior art date
Application number
DK90901896.2T
Other languages
English (en)
Inventor
Kazuhiro Ohsuye
Shoji Tanaka
Koji Magota
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of DK0408764T3 publication Critical patent/DK0408764T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003—Peptidylglycine monooxygenase (1.14.17.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK90901896.2T 1989-01-17 1990-01-17 Fremgangsmåde til fremstilling af alfa-amiderede peptider DK0408764T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1005879A JP2535398B2 (ja) 1989-01-17 1989-01-17 アミド化ペプチドの製造方法

Publications (1)

Publication Number Publication Date
DK0408764T3 true DK0408764T3 (da) 1995-07-17

Family

ID=11623192

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90901896.2T DK0408764T3 (da) 1989-01-17 1990-01-17 Fremgangsmåde til fremstilling af alfa-amiderede peptider

Country Status (10)

Country Link
EP (1) EP0408764B1 (da)
JP (1) JP2535398B2 (da)
KR (1) KR960013618B1 (da)
AT (1) ATE122099T1 (da)
AU (1) AU630150B2 (da)
CA (1) CA2025350C (da)
DE (1) DE69019077T2 (da)
DK (1) DK0408764T3 (da)
ES (1) ES2072422T3 (da)
WO (1) WO1990008194A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
DK67691D0 (da) * 1991-03-01 1991-04-15 Carlbiotech Ltd As Enzymatisk fremgangsmaade til c-terminal modificering af peptider og mellemprodukter til brug ved fremgangsmaaden
JP3531947B2 (ja) * 1991-08-19 2004-05-31 第一サントリーファーマ株式会社 ペプチドの製造方法
JPH0775593A (ja) * 1993-09-08 1995-03-20 Suntory Ltd 蛋白質の製造方法
AU4415796A (en) * 1994-12-07 1996-06-26 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
CN1069699C (zh) * 1997-04-16 2001-08-15 中国科学院上海生物化学研究所 一种活性重组酰胺化酶及其对多肽的酰胺化修饰应用
CN1100789C (zh) * 2000-01-13 2003-02-05 中国人民解放军第二军医大学 基因重组降钙素或降钙素类似物的制备方法
ES2583259T3 (es) 2009-12-01 2016-09-20 Novo Nordisk A/S Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH089639B2 (ja) * 1982-05-20 1996-01-31 サントリー株式会社 Ｃ末端アミド化ペプチドの前駆体およびその製造法
EP0134631B1 (en) * 1983-06-15 1991-04-03 Celltech Limited Peptides, pharmaceutical compositions, genes, vectors, host organisms, processes for their production and diagnostic reagents
JPS6229997A (ja) * 1985-04-08 1987-02-07 Sankyo Co Ltd Ｃ末端にプロリンアミドを有するペプチドの製法
GB8523156D0 (en) * 1985-09-19 1985-10-23 Celltech Ltd Polypeptide production
JPS62226998A (ja) * 1986-03-28 1987-10-05 Takara Shuzo Co Ltd ヒトカルシトニン前駆体ペプチド及びその製造方法
JPH0775541B2 (ja) * 1986-06-07 1995-08-16 壽之 松尾 Ｃ末端アミド化酵素及びその製造方法
US4987070A (en) * 1987-03-04 1991-01-22 Suntory Limited Use of a 97 amino acid leader sequence from the E. coli B-galactosidase gene for the production of hanp and hptc as fusion proteins
JP2598050B2 (ja) * 1987-07-17 1997-04-09 サントリー株式会社 Ｃ−末端α−アミド化酵素

Also Published As

Publication number Publication date
CA2025350C (en) 2000-08-01
CA2025350A1 (en) 1990-07-18
KR910700351A (ko) 1991-03-14
DE69019077T2 (de) 1995-08-31
JPH02190193A (ja) 1990-07-26
KR960013618B1 (ko) 1996-10-09
DE69019077D1 (de) 1995-06-08
ES2072422T3 (es) 1995-07-16
AU630150B2 (en) 1992-10-22
WO1990008194A1 (en) 1990-07-26
EP0408764A1 (en) 1991-01-23
ATE122099T1 (de) 1995-05-15
AU4948490A (en) 1990-08-13
EP0408764B1 (en) 1995-05-03
JP2535398B2 (ja) 1996-09-18

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