DK0885230T3 - Camptothecinderivater og deres anvendelse som antitumormidler - Google Patents
Camptothecinderivater og deres anvendelse som antitumormidlerInfo
- Publication number
- DK0885230T3 DK0885230T3 DK97905057T DK97905057T DK0885230T3 DK 0885230 T3 DK0885230 T3 DK 0885230T3 DK 97905057 T DK97905057 T DK 97905057T DK 97905057 T DK97905057 T DK 97905057T DK 0885230 T3 DK0885230 T3 DK 0885230T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- camptothecin derivatives
- antitumor agents
- date aug
- sec
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
- -1 4,5-dihydrooxazol-2-yl Chemical group 0.000 abstract 1
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000338A IT1282673B1 (it) | 1996-02-23 | 1996-02-23 | Derivati della camptotecina e loro uso come agenti antitumorali |
| PCT/EP1997/000786 WO1997031003A1 (en) | 1996-02-23 | 1997-02-19 | Camptothecin derivatives and the use thereof as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0885230T3 true DK0885230T3 (da) | 2002-11-18 |
Family
ID=11373368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97905057T DK0885230T3 (da) | 1996-02-23 | 1997-02-19 | Camptothecinderivater og deres anvendelse som antitumormidler |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6130227A (OSRAM) |
| EP (1) | EP0885230B1 (OSRAM) |
| JP (1) | JP4171527B2 (OSRAM) |
| KR (1) | KR100497906B1 (OSRAM) |
| CN (1) | CN1107677C (OSRAM) |
| AT (1) | ATE221071T1 (OSRAM) |
| AU (1) | AU718361B2 (OSRAM) |
| BR (1) | BR9707622B1 (OSRAM) |
| CZ (1) | CZ289268B6 (OSRAM) |
| DE (1) | DE69714220T2 (OSRAM) |
| DK (1) | DK0885230T3 (OSRAM) |
| EE (1) | EE03529B1 (OSRAM) |
| ES (1) | ES2180932T3 (OSRAM) |
| HU (1) | HUP9900987A3 (OSRAM) |
| IL (1) | IL125856A (OSRAM) |
| IT (1) | IT1282673B1 (OSRAM) |
| NZ (1) | NZ331126A (OSRAM) |
| PT (1) | PT885230E (OSRAM) |
| RU (1) | RU2165935C2 (OSRAM) |
| SK (1) | SK283217B6 (OSRAM) |
| UA (1) | UA49005C2 (OSRAM) |
| WO (1) | WO1997031003A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000000238A1 (en) * | 1998-06-26 | 2000-01-06 | Quanam Medical Corporation | Topoisomerase inhibitors for prevention of restenosis |
| DK1044977T3 (da) * | 1999-03-09 | 2002-07-08 | Sigma Tau Ind Farmaceuti | Camptothecinderivater med antitumoraktivitet |
| US7105492B2 (en) | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| WO2002083938A2 (en) * | 2001-04-11 | 2002-10-24 | Emerald Biostructures, Inc. | Screening methods for identifying ligands |
| RU2319482C2 (ru) * | 2001-11-23 | 2008-03-20 | Чугаи Сейяку Кабусики Кайся | Способ идентификации противоопухолевых целевых ферментов |
| AU2003215594A1 (en) * | 2002-03-01 | 2003-09-16 | Pharmacia Italia S.P.A. | Crystalline polymorphic form of irinotecan hydrochloride |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| AR046579A1 (es) * | 2003-11-12 | 2005-12-14 | Smithkline Beecham Corp | Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica |
| EP1962850B1 (en) * | 2005-12-21 | 2012-03-07 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Treatment of drug-resistant tumors |
| WO2007095389A2 (en) * | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
| CN101033230B (zh) | 2006-03-10 | 2010-12-08 | 中国科学院上海药物研究所 | 一类喜树碱衍生物及其应用 |
| ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
| CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
| US20240376120A1 (en) * | 2021-09-01 | 2024-11-14 | Shanghai Best-Link Bioscience, Llc | Camptothecin compound, preparation method therefor and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
| US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| WO1998007727A1 (en) * | 1996-08-19 | 1998-02-26 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
-
1996
- 1996-02-23 IT IT96MI000338A patent/IT1282673B1/it active IP Right Grant
-
1997
- 1997-02-19 PT PT97905057T patent/PT885230E/pt unknown
- 1997-02-19 US US09/125,512 patent/US6130227A/en not_active Expired - Fee Related
- 1997-02-19 DE DE69714220T patent/DE69714220T2/de not_active Expired - Lifetime
- 1997-02-19 NZ NZ331126A patent/NZ331126A/en not_active IP Right Cessation
- 1997-02-19 DK DK97905057T patent/DK0885230T3/da active
- 1997-02-19 AU AU18753/97A patent/AU718361B2/en not_active Ceased
- 1997-02-19 CN CN97192493A patent/CN1107677C/zh not_active Expired - Fee Related
- 1997-02-19 KR KR1019980706498A patent/KR100497906B1/ko not_active Expired - Fee Related
- 1997-02-19 JP JP52979197A patent/JP4171527B2/ja not_active Expired - Fee Related
- 1997-02-19 RU RU98117449/04A patent/RU2165935C2/ru not_active IP Right Cessation
- 1997-02-19 ES ES97905057T patent/ES2180932T3/es not_active Expired - Lifetime
- 1997-02-19 EP EP97905057A patent/EP0885230B1/en not_active Expired - Lifetime
- 1997-02-19 HU HU9900987A patent/HUP9900987A3/hu unknown
- 1997-02-19 AT AT97905057T patent/ATE221071T1/de not_active IP Right Cessation
- 1997-02-19 EE EE9800259A patent/EE03529B1/xx not_active IP Right Cessation
- 1997-02-19 WO PCT/EP1997/000786 patent/WO1997031003A1/en not_active Application Discontinuation
- 1997-02-19 CZ CZ19982652A patent/CZ289268B6/cs not_active IP Right Cessation
- 1997-02-19 UA UA98084449A patent/UA49005C2/uk unknown
- 1997-02-19 IL IL12585697A patent/IL125856A/xx not_active IP Right Cessation
- 1997-02-19 SK SK1127-98A patent/SK283217B6/sk not_active IP Right Cessation
- 1997-02-19 BR BRPI9707622-8A patent/BR9707622B1/pt not_active IP Right Cessation
-
2000
- 2000-08-22 US US09/643,256 patent/US6306868B1/en not_active Expired - Fee Related
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