IL125856A - 7-substituted camptothecin derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
7-substituted camptothecin derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL125856A IL125856A IL12585697A IL12585697A IL125856A IL 125856 A IL125856 A IL 125856A IL 12585697 A IL12585697 A IL 12585697A IL 12585697 A IL12585697 A IL 12585697A IL 125856 A IL125856 A IL 125856A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- camptothecin derivatives
- pharmaceutical compositions
- pct
- compositions containing
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 4,5-dihydrooxazol-2-yl Chemical group 0.000 abstract 1
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000338A IT1282673B1 (it) | 1996-02-23 | 1996-02-23 | Derivati della camptotecina e loro uso come agenti antitumorali |
| PCT/EP1997/000786 WO1997031003A1 (en) | 1996-02-23 | 1997-02-19 | Camptothecin derivatives and the use thereof as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125856A0 IL125856A0 (en) | 1999-04-11 |
| IL125856A true IL125856A (en) | 2001-08-26 |
Family
ID=11373368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12585697A IL125856A (en) | 1996-02-23 | 1997-02-19 | 7-substituted camptothecin derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6130227A (OSRAM) |
| EP (1) | EP0885230B1 (OSRAM) |
| JP (1) | JP4171527B2 (OSRAM) |
| KR (1) | KR100497906B1 (OSRAM) |
| CN (1) | CN1107677C (OSRAM) |
| AT (1) | ATE221071T1 (OSRAM) |
| AU (1) | AU718361B2 (OSRAM) |
| BR (1) | BR9707622B1 (OSRAM) |
| CZ (1) | CZ289268B6 (OSRAM) |
| DE (1) | DE69714220T2 (OSRAM) |
| DK (1) | DK0885230T3 (OSRAM) |
| EE (1) | EE03529B1 (OSRAM) |
| ES (1) | ES2180932T3 (OSRAM) |
| HU (1) | HUP9900987A3 (OSRAM) |
| IL (1) | IL125856A (OSRAM) |
| IT (1) | IT1282673B1 (OSRAM) |
| NZ (1) | NZ331126A (OSRAM) |
| PT (1) | PT885230E (OSRAM) |
| RU (1) | RU2165935C2 (OSRAM) |
| SK (1) | SK283217B6 (OSRAM) |
| UA (1) | UA49005C2 (OSRAM) |
| WO (1) | WO1997031003A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69900689T2 (de) * | 1998-06-26 | 2002-08-29 | Quanam Medical Corp., Santa Clara | Topoisomerase inhibitoren zur restenose-prevention |
| US7105492B2 (en) | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| DK1044977T3 (da) | 1999-03-09 | 2002-07-08 | Sigma Tau Ind Farmaceuti | Camptothecinderivater med antitumoraktivitet |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| US6950757B2 (en) * | 2001-04-11 | 2005-09-27 | Emerald Biostructures, Inc. | Screening methods for identifying ligands |
| RU2319482C2 (ru) * | 2001-11-23 | 2008-03-20 | Чугаи Сейяку Кабусики Кайся | Способ идентификации противоопухолевых целевых ферментов |
| BR0308133A (pt) * | 2002-03-01 | 2005-01-04 | Pharmacia Italia Spa | Forma polimórfica cristalina de cloridrato de irinotecan |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
| BRPI0620209A2 (pt) | 2005-12-21 | 2011-11-01 | Sigma Tau Ind Famaceutiche Riunite S P A | tratamento de tumores resistentes a fármacos |
| WO2007095389A2 (en) * | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
| CN101033230B (zh) * | 2006-03-10 | 2010-12-08 | 中国科学院上海药物研究所 | 一类喜树碱衍生物及其应用 |
| ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
| CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
| WO2023030364A1 (zh) * | 2021-09-01 | 2023-03-09 | 上海弼领生物技术有限公司 | 一种喜树碱类化合物、其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
| US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| WO1998007727A1 (en) * | 1996-08-19 | 1998-02-26 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
-
1996
- 1996-02-23 IT IT96MI000338A patent/IT1282673B1/it active IP Right Grant
-
1997
- 1997-02-19 BR BRPI9707622-8A patent/BR9707622B1/pt not_active IP Right Cessation
- 1997-02-19 NZ NZ331126A patent/NZ331126A/en not_active IP Right Cessation
- 1997-02-19 SK SK1127-98A patent/SK283217B6/sk not_active IP Right Cessation
- 1997-02-19 IL IL12585697A patent/IL125856A/xx not_active IP Right Cessation
- 1997-02-19 US US09/125,512 patent/US6130227A/en not_active Expired - Fee Related
- 1997-02-19 AT AT97905057T patent/ATE221071T1/de not_active IP Right Cessation
- 1997-02-19 PT PT97905057T patent/PT885230E/pt unknown
- 1997-02-19 RU RU98117449/04A patent/RU2165935C2/ru not_active IP Right Cessation
- 1997-02-19 DE DE69714220T patent/DE69714220T2/de not_active Expired - Lifetime
- 1997-02-19 DK DK97905057T patent/DK0885230T3/da active
- 1997-02-19 WO PCT/EP1997/000786 patent/WO1997031003A1/en not_active Application Discontinuation
- 1997-02-19 CZ CZ19982652A patent/CZ289268B6/cs not_active IP Right Cessation
- 1997-02-19 HU HU9900987A patent/HUP9900987A3/hu unknown
- 1997-02-19 ES ES97905057T patent/ES2180932T3/es not_active Expired - Lifetime
- 1997-02-19 KR KR1019980706498A patent/KR100497906B1/ko not_active Expired - Fee Related
- 1997-02-19 CN CN97192493A patent/CN1107677C/zh not_active Expired - Fee Related
- 1997-02-19 AU AU18753/97A patent/AU718361B2/en not_active Ceased
- 1997-02-19 UA UA98084449A patent/UA49005C2/uk unknown
- 1997-02-19 EE EE9800259A patent/EE03529B1/xx not_active IP Right Cessation
- 1997-02-19 EP EP97905057A patent/EP0885230B1/en not_active Expired - Lifetime
- 1997-02-19 JP JP52979197A patent/JP4171527B2/ja not_active Expired - Fee Related
-
2000
- 2000-08-22 US US09/643,256 patent/US6306868B1/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |