DK0883602T3 - Lipidforbindelser - Google Patents

Lipidforbindelser

Info

Publication number
DK0883602T3
DK0883602T3 DK97904417T DK97904417T DK0883602T3 DK 0883602 T3 DK0883602 T3 DK 0883602T3 DK 97904417 T DK97904417 T DK 97904417T DK 97904417 T DK97904417 T DK 97904417T DK 0883602 T3 DK0883602 T3 DK 0883602T3
Authority
DK
Denmark
Prior art keywords
lipid compounds
novel lipid
biologically active
active substances
invention concerns
Prior art date
Application number
DK97904417T
Other languages
Danish (da)
English (en)
Inventor
Andrej Sourovoi
Guenther Jung
Original Assignee
Andrej Sourovoi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andrej Sourovoi filed Critical Andrej Sourovoi
Application granted granted Critical
Publication of DK0883602T3 publication Critical patent/DK0883602T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK97904417T 1996-02-13 1997-02-12 Lipidforbindelser DK0883602T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19605175A DE19605175A1 (de) 1996-02-13 1996-02-13 Lipidverbindungen und deren Verwendung
PCT/EP1997/000629 WO1997030024A2 (fr) 1996-02-13 1997-02-12 Composes lipidiques et leur utilisation, par exemple, dans des liposomes

Publications (1)

Publication Number Publication Date
DK0883602T3 true DK0883602T3 (da) 2003-01-06

Family

ID=7785229

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97904417T DK0883602T3 (da) 1996-02-13 1997-02-12 Lipidforbindelser

Country Status (11)

Country Link
US (1) US6458381B1 (fr)
EP (1) EP0883602B1 (fr)
JP (1) JP3525393B2 (fr)
AT (1) ATE223374T1 (fr)
AU (1) AU713039B2 (fr)
CA (1) CA2246456C (fr)
DE (2) DE19605175A1 (fr)
DK (1) DK0883602T3 (fr)
ES (1) ES2183133T3 (fr)
PT (1) PT883602E (fr)
WO (1) WO1997030024A2 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050074747A1 (en) * 2000-09-08 2005-04-07 Wadih Arap Biopanning and rapid analysis of selective interactive ligands (brasil)
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
EP1418932A4 (fr) * 2001-07-18 2006-03-15 Univ Texas Etat anti-angiogene chez les souris et les etres humains souffrant d'une degenerescence cellulaire du photorecepteur retinien
US20040048243A1 (en) * 2001-09-07 2004-03-11 Wadih Arap Methods and compositions for in vitro targeting
US7671010B2 (en) * 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US8507445B2 (en) * 2001-09-07 2013-08-13 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
EP1497314A4 (fr) * 2001-09-07 2007-10-10 Univ Texas Compositions et procedes d'utilisation de peptides de ciblage contre les tissus adipeux et placentaires
FR2861392B1 (fr) * 2003-10-23 2006-02-03 Ts Pharma Nouveaux tensio -actifs et leurs applications
EP1708993A2 (fr) * 2003-10-23 2006-10-11 TS Pharma Nouveaux tensio-actifs et leurs applications
MXPA06010346A (es) * 2004-03-17 2007-04-23 7Tm Pharma As Agonistas de receptor selectivo de y2/y4 para intervenciones terapeuticas.
US20090186811A1 (en) * 2004-03-17 2009-07-23 Thue Schwartz Y2 Selective Receptor Agonists for Therapeutic Interventions
AU2005337116A1 (en) * 2005-09-21 2007-04-12 7Tm Pharma A/S Y4 selective receptor agonists for therapeutic interventions
JP2009508886A (ja) * 2005-09-21 2009-03-05 7ティーエム ファーマ エイ/エス 治療的介入のためのy2選択性レセプターアゴニスト
DE102007015377A1 (de) 2007-03-28 2008-10-02 Qiagen Gmbh Verfahren zur Herstellung einer transformierten Zelle
GB0708226D0 (en) * 2007-04-27 2007-06-06 7Tm Pharma As Y-receptor agonists
DK2494993T3 (en) * 2007-05-04 2018-11-12 Marina Biotech Inc Amino acid lipids and uses thereof
DE102008032594A1 (de) 2008-07-11 2010-01-14 Qiagen Gmbh Transfektionslösung
WO2010135714A2 (fr) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Méthodes de modulation de l'expression des adipocytes utilisant des compositions de micro-arn
WO2011071860A2 (fr) 2009-12-07 2011-06-16 Alnylam Pharmaceuticals, Inc. Compositions utilisées pour l'administration d'acides nucléiques
GB201008267D0 (en) 2010-05-18 2010-06-30 Univ Edinburgh Cationic lipids
AU2012347637B2 (en) 2011-12-07 2017-09-14 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
RS63848B1 (sr) 2014-06-25 2023-01-31 Acuitas Therapeutics Inc Novi lipidi i formulacije lipidnih nanočestica za isporuku nukleinskih kiselina
AU2016281685B2 (en) * 2015-06-24 2021-08-12 Nitto Denko Corporation Ionizable compounds and compositions and uses thereof
CN107922364B (zh) 2015-06-29 2021-12-31 爱康泰生治疗公司 用于递送核酸的脂质和脂质纳米颗粒制剂
JP7030690B2 (ja) 2015-10-28 2022-03-07 アキィタス・セラピューティクス・インコーポレイテッド 核酸のデリバリーのための新規脂質および脂質ナノ粒子製剤
US11357856B2 (en) 2017-04-13 2022-06-14 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
AU2018256877B2 (en) 2017-04-28 2022-06-02 Acuitas Therapeutics, Inc. Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2019036008A1 (fr) 2017-08-16 2019-02-21 Acuitas Therapeutics, Inc. Lipides destinés à être utilisés dans des formulations nanoparticulaires lipidiques
WO2019036028A1 (fr) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. Lipides destinés à être utilisés dans des formulations nanoparticulaires lipidiques
WO2019036030A1 (fr) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. Lipides destinés à être utilisés dans des formulations de nanoparticules lipidiques
WO2020146805A1 (fr) 2019-01-11 2020-07-16 Acuitas Therapeutics, Inc. Lipides pour l'administration de nanoparticules lipidiques d'agents actifs
EP4182297A1 (fr) 2020-07-16 2023-05-24 Acuitas Therapeutics, Inc. Lipides cationiques destinés à être utilisés dans des nanoparticules lipidiques

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621479A5 (fr) 1977-08-05 1981-02-13 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4241046A (en) 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS60228564A (ja) * 1984-04-27 1985-11-13 Tokuyama Soda Co Ltd 液晶性組成物
JPS6137892A (ja) 1984-07-31 1986-02-22 Tokuyama Soda Co Ltd 液晶組成物
US5208036A (en) * 1985-01-07 1993-05-04 Syntex (U.S.A.) Inc. N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
NZ214716A (en) 1985-01-07 1989-04-26 Syntex Inc 1,2-dialkoxy-omega-trialkylammonium cationic surfactants
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5049386A (en) * 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) * 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
DE3803225A1 (de) * 1988-02-04 1989-08-17 Hoechst Ag Aminosaeureamide mit psychotroper wirkung, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
AU3203489A (en) 1988-02-19 1989-09-22 Upjohn Company, The Lipophilic polyamines useful for treating hypercholesterolemia
JP2923296B2 (ja) 1988-11-14 1999-07-26 株式会社ビタミン研究所 細胞への遺伝子導入法
WO1991009837A1 (fr) * 1989-12-22 1991-07-11 Commonwealth Scientific And Industrial Research Organisation Acides amines, peptides ou leurs derives associes a des graisses
ES2221920T3 (es) 1992-04-03 2005-01-16 The Regents Of The University Of California Sistema de liberacion de polinucleotidos de autoensamblaje que comprende un peptido cationico anfipatico.
JPH06340598A (ja) 1993-05-28 1994-12-13 Lion Corp 新規なジエステルジアミン化合物、その中間体及びその製造方法と柔軟剤
US5674908A (en) * 1993-12-20 1997-10-07 Life Technologies, Inc. Highly packed polycationic ammonium, sulfonium and phosphonium lipids
FR2714830B1 (fr) * 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US5753613A (en) * 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells

Also Published As

Publication number Publication date
CA2246456A1 (fr) 1997-08-21
PT883602E (pt) 2003-01-31
EP0883602A2 (fr) 1998-12-16
DE19605175A1 (de) 1997-08-14
AU1724097A (en) 1997-09-02
ATE223374T1 (de) 2002-09-15
DE59708130D1 (de) 2002-10-10
AU713039B2 (en) 1999-11-18
ES2183133T3 (es) 2003-03-16
JPH11506795A (ja) 1999-06-15
WO1997030024A3 (fr) 1997-09-25
EP0883602B1 (fr) 2002-09-04
WO1997030024A2 (fr) 1997-08-21
CA2246456C (fr) 2004-07-20
JP3525393B2 (ja) 2004-05-10
US6458381B1 (en) 2002-10-01

Similar Documents

Publication Publication Date Title
DK0883602T3 (da) Lipidforbindelser
NO991942L (no) FremgangsmÕte for fremstilling av malonat metyliden nanopartikler, nanopartikler eventuelt inneholdende ett eller flere biologisk aktive molekyler
Weber et al. Antibiotics from basidiomycetes XXXII. Strobilurin E: A new cytostatic and antifungal (E)-β-methoxyacrylate antibiotic from Crepidotus fulvotomentosus Peck
ATE273320T1 (de) Fusogene liposomen
DE69906977D1 (de) In liposomen verkapselte nukleinsäurekomplexe
NO993709D0 (no) Stabilisert blanding omfattende fibrinogen
ATE286126T1 (de) Glialmitogene faktoren, ihre herstellung und verwendung
DE69637147D1 (de) Transportproteine und deren verwendungen
WO1999020766A3 (fr) SEQUENCES D'ACIDES NUCLEIQUES MODIFIES ET PROCEDES PERMETTANT D'ACCROITRE LES NIVEAUX D'ARNm ET L'EXPRESSION DES PROTEINES DANS LES SYSTEMES CELLULAIRES
AU9058091A (en) Preparation of nucleic acid samples
ATE316571T1 (de) Purifikation von viruspräparaten
CA2092866A1 (fr) Solutions de fixation et methode de coloration des cellules sans la destruction de la surface cellulaire
FI104177B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten oligonukleotidien valmistamiseksi
DE69942459D1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
FI885504A (fi) Vaskulaera antikoagulerande proteiner, dessa koderande dna, deras framstaellningsfoerfarande och deras anvaendning.
DE3884680D1 (de) Äusseres Membranprotein F von Pseudomonas aeruginosa.
DE19781038T1 (de) Keratinozytenwachstumsfaktor-2-Produkte
DE69524971D1 (de) Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen
DE69734596D1 (de) "smoothened" proteine aus wirbeltieren
WO1999064439A3 (fr) Procedes utiles pour accroitre la production de peptides antimicrobiens cationiques
ATE205538T1 (de) Genregulatorische sequenzen von cd4, welche spezifisch in reifen t-zellen exprimiert werden
DE69923595D1 (de) Herstellung von proteinen
Kaul et al. Evidence and nature of a novel thiol-oxidase in human platelets
AU1705097A (en) Bacterial donor cell useful in conjugation
DE59106119D1 (de) Stabilisatorkombinationen und ihre Verwendung zur Herstellung von stabilisierten, schlagzähmodifizierten Polyamiden.