DK0873123T3 - Inhibitorer af protein-isoprenyltransferaser - Google Patents

Inhibitorer af protein-isoprenyltransferaser

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Publication number
DK0873123T3
DK0873123T3 DK96938647T DK96938647T DK0873123T3 DK 0873123 T3 DK0873123 T3 DK 0873123T3 DK 96938647 T DK96938647 T DK 96938647T DK 96938647 T DK96938647 T DK 96938647T DK 0873123 T3 DK0873123 T3 DK 0873123T3
Authority
DK
Denmark
Prior art keywords
heterocyclic
formula
inhibitors
protein isoprenyl
transferases
Prior art date
Application number
DK96938647T
Other languages
Danish (da)
English (en)
Inventor
Said M Sebti
Andrew D Hamilton
Saul H Rosenberg
David J Augeri
Kenneth J Barr
Bernard G Donner
Stephen A Fakhhoury
David A Janowick
Douglas M Kalvin
John J Larsen
Gang Liu
Stephen J O'connor
Wang Shen
Rolf E Swenson
Bryan K Sorenson
Gerard M Sullivan
Bruce Szczepankiewicz
Andrew S Tasker
James T Wasicak
Martin Winn
Original Assignee
Univ Pittsburgh
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Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Application granted granted Critical
Publication of DK0873123T3 publication Critical patent/DK0873123T3/da

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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DK96938647T 1995-11-06 1996-11-05 Inhibitorer af protein-isoprenyltransferaser DK0873123T3 (da)

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US724795P 1995-11-06 1995-11-06
PCT/US1996/017092 WO1997017070A1 (en) 1995-11-06 1996-11-05 Inhibitors of protein isoprenyl transferases

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EP (1) EP0873123B1 (ja)
JP (1) JP4533466B2 (ja)
AT (1) ATE236632T1 (ja)
AU (1) AU7597596A (ja)
CA (1) CA2235986C (ja)
DE (1) DE69627377T2 (ja)
DK (1) DK0873123T3 (ja)
ES (1) ES2196186T3 (ja)
MX (1) MX9803589A (ja)
PT (1) PT873123E (ja)
WO (1) WO1997017070A1 (ja)
ZA (1) ZA969273B (ja)

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EP0873123A4 (en) 1999-02-03
PT873123E (pt) 2003-08-29
AU7597596A (en) 1997-05-29
CA2235986C (en) 2006-09-12
MX9803589A (es) 1998-11-30
JP4533466B2 (ja) 2010-09-01
ES2196186T3 (es) 2003-12-16
WO1997017070A1 (en) 1997-05-15
DE69627377T2 (de) 2004-02-05
JP2000500745A (ja) 2000-01-25
EP0873123A1 (en) 1998-10-28
ATE236632T1 (de) 2003-04-15
ZA969273B (en) 1998-05-05
CA2235986A1 (en) 1997-05-15
EP0873123B1 (en) 2003-04-09
DE69627377D1 (de) 2003-05-15

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