DK0873123T3 - Inhibitorer af protein-isoprenyltransferaser - Google Patents
Inhibitorer af protein-isoprenyltransferaserInfo
- Publication number
- DK0873123T3 DK0873123T3 DK96938647T DK96938647T DK0873123T3 DK 0873123 T3 DK0873123 T3 DK 0873123T3 DK 96938647 T DK96938647 T DK 96938647T DK 96938647 T DK96938647 T DK 96938647T DK 0873123 T3 DK0873123 T3 DK 0873123T3
- Authority
- DK
- Denmark
- Prior art keywords
- heterocyclic
- formula
- inhibitors
- protein isoprenyl
- transferases
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/62—Oxygen or sulfur atoms
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- C07D213/72—Nitrogen atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US724795P | 1995-11-06 | 1995-11-06 | |
PCT/US1996/017092 WO1997017070A1 (en) | 1995-11-06 | 1996-11-05 | Inhibitors of protein isoprenyl transferases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0873123T3 true DK0873123T3 (da) | 2003-08-04 |
Family
ID=21725070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96938647T DK0873123T3 (da) | 1995-11-06 | 1996-11-05 | Inhibitorer af protein-isoprenyltransferaser |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0873123B1 (ja) |
JP (1) | JP4533466B2 (ja) |
AT (1) | ATE236632T1 (ja) |
AU (1) | AU7597596A (ja) |
CA (1) | CA2235986C (ja) |
DE (1) | DE69627377T2 (ja) |
DK (1) | DK0873123T3 (ja) |
ES (1) | ES2196186T3 (ja) |
MX (1) | MX9803589A (ja) |
PT (1) | PT873123E (ja) |
WO (1) | WO1997017070A1 (ja) |
ZA (1) | ZA969273B (ja) |
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Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT72440A (en) * | 1994-03-31 | 1996-04-29 | Bristol Myers Squibb Co | Imidazole-containing inhibitors of farnesyl protein transferase and pharmaceutical compositions containing them |
-
1996
- 1996-11-05 JP JP51820897A patent/JP4533466B2/ja not_active Expired - Lifetime
- 1996-11-05 DE DE69627377T patent/DE69627377T2/de not_active Expired - Lifetime
- 1996-11-05 AU AU75975/96A patent/AU7597596A/en not_active Abandoned
- 1996-11-05 ES ES96938647T patent/ES2196186T3/es not_active Expired - Lifetime
- 1996-11-05 AT AT96938647T patent/ATE236632T1/de active
- 1996-11-05 CA CA002235986A patent/CA2235986C/en not_active Expired - Lifetime
- 1996-11-05 DK DK96938647T patent/DK0873123T3/da active
- 1996-11-05 EP EP96938647A patent/EP0873123B1/en not_active Expired - Lifetime
- 1996-11-05 PT PT96938647T patent/PT873123E/pt unknown
- 1996-11-05 WO PCT/US1996/017092 patent/WO1997017070A1/en active IP Right Grant
- 1996-11-05 ZA ZA9609273A patent/ZA969273B/xx unknown
-
1998
- 1998-05-06 MX MX9803589A patent/MX9803589A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX9803589A (es) | 1998-11-30 |
DE69627377D1 (de) | 2003-05-15 |
EP0873123A1 (en) | 1998-10-28 |
ES2196186T3 (es) | 2003-12-16 |
JP2000500745A (ja) | 2000-01-25 |
AU7597596A (en) | 1997-05-29 |
EP0873123A4 (en) | 1999-02-03 |
DE69627377T2 (de) | 2004-02-05 |
PT873123E (pt) | 2003-08-29 |
CA2235986C (en) | 2006-09-12 |
JP4533466B2 (ja) | 2010-09-01 |
WO1997017070A1 (en) | 1997-05-15 |
CA2235986A1 (en) | 1997-05-15 |
ATE236632T1 (de) | 2003-04-15 |
ZA969273B (en) | 1998-05-05 |
EP0873123B1 (en) | 2003-04-09 |
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