DK0871625T3 - Fremstilling af triazoler ved organometallisk tilsætning af ketoner og mellemprodukter dertil - Google Patents

Fremstilling af triazoler ved organometallisk tilsætning af ketoner og mellemprodukter dertil

Info

Publication number
DK0871625T3
DK0871625T3 DK96927644T DK96927644T DK0871625T3 DK 0871625 T3 DK0871625 T3 DK 0871625T3 DK 96927644 T DK96927644 T DK 96927644T DK 96927644 T DK96927644 T DK 96927644T DK 0871625 T3 DK0871625 T3 DK 0871625T3
Authority
DK
Denmark
Prior art keywords
triazoles
intermediates
ketones
preparation
organometallic addition
Prior art date
Application number
DK96927644T
Other languages
English (en)
Inventor
Michael Butters
Julie Ann Harrison
Alan John Pettman
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10778850&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0871625(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Application granted granted Critical
Publication of DK0871625T3 publication Critical patent/DK0871625T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK96927644T 1995-08-05 1996-07-26 Fremstilling af triazoler ved organometallisk tilsætning af ketoner og mellemprodukter dertil DK0871625T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9516121.2A GB9516121D0 (en) 1995-08-05 1995-08-05 Organometallic addition to ketones
PCT/EP1996/003376 WO1997006160A1 (en) 1995-08-05 1996-07-26 Preparation of triazoles by organometallic addition to ketones and intermediates therefor

Publications (1)

Publication Number Publication Date
DK0871625T3 true DK0871625T3 (da) 2004-03-29

Family

ID=10778850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96927644T DK0871625T3 (da) 1995-08-05 1996-07-26 Fremstilling af triazoler ved organometallisk tilsætning af ketoner og mellemprodukter dertil

Country Status (32)

Country Link
US (2) US6586594B1 (da)
EP (1) EP0871625B1 (da)
JP (3) JP3211965B2 (da)
KR (1) KR100269048B1 (da)
CN (1) CN1076019C (da)
AR (1) AR003472A1 (da)
AT (1) ATE256679T1 (da)
AU (1) AU703337B2 (da)
BR (1) BR9609960A (da)
CA (1) CA2228655C (da)
CZ (1) CZ296975B6 (da)
DE (1) DE69631160T2 (da)
DK (1) DK0871625T3 (da)
EG (1) EG21200A (da)
ES (1) ES2210382T3 (da)
GB (1) GB9516121D0 (da)
HK (1) HK1014944A1 (da)
HU (1) HU224339B1 (da)
IL (2) IL122462A (da)
IN (1) IN190817B (da)
MX (1) MX9801025A (da)
MY (1) MY123062A (da)
NO (1) NO314938B1 (da)
NZ (1) NZ315651A (da)
PE (1) PE16897A1 (da)
PL (1) PL187227B1 (da)
PT (1) PT871625E (da)
RU (1) RU2156760C2 (da)
TR (1) TR199800170T1 (da)
TW (1) TW442480B (da)
WO (1) WO1997006160A1 (da)
ZA (1) ZA966587B (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193083B2 (en) * 1996-07-26 2007-03-20 Pfizer, Inc. Preparation of triazoles by organometallic addition to ketones and intermediates therefor
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US7517886B2 (en) * 2002-07-29 2009-04-14 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
PT1656372E (pt) 2003-07-30 2013-06-27 Rigel Pharmaceuticals Inc Métodos para o tratamento ou prevenção de doenças autoimunes com compostos de 2,4-pirimidinadiamina
EP1786783A1 (en) * 2004-09-01 2007-05-23 Rigel Pharmaceuticals, Inc. Synthesis of 2,4-pyrimidinediamine compounds
JP5095409B2 (ja) * 2004-11-24 2012-12-12 ライジェル ファーマシューティカルズ， インコーポレイテッド スピロ２，４−ピリミジンジアミン化合物およびその使用
EP1828170A4 (en) * 2004-12-14 2009-11-11 Reddys Lab Ltd Dr PROCESS FOR PREPARING VORICONAZOLE
WO2007027238A2 (en) * 2005-05-03 2007-03-08 Rigel Pharmaceuticals, Inc. Jak kinase inhibitors and their uses
CA2640922A1 (en) * 2006-02-01 2007-11-22 Medichem, S.A. Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
AR061889A1 (es) 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) * 2006-09-14 2013-01-02 大道隆达（北京）医药科技发展有限公司 伏立康唑及其药用盐、中间体的一种新定向合成制备方法
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
WO2009084029A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
US20110312977A1 (en) * 2009-02-17 2011-12-22 Glenmark Generics Limited Process for the preparation of voriconazole
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
JP2013516394A (ja) 2009-12-30 2013-05-13 メディケム ソシエダ アノニマ 医薬用途用の１−（１ｈ−１，２，４−トリアゾール−１−イル）ブタン−２−オール誘導体、および前記１−（１ｈ−１，２，４−トリアゾール−１−イル）ブタン−２−オール誘導体を調製するための、実質的に不定の結晶形状を有する１−（１ｈ−１，２，４−トリアゾール−１−イル）ブタン−２−オール誘導体の使用
KR100971371B1 (ko) 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
WO2011110198A1 (en) 2010-03-10 2011-09-15 Synthron B.V. A process for making voriconazole
CN102344441B (zh) * 2010-07-25 2015-05-06 浙江华海药业股份有限公司 一种制备伏立康唑中间体的工艺改进方法
CN101914091B (zh) * 2010-07-25 2015-05-27 浙江华海药业股份有限公司 一种制备伏立康唑中间体的方法
US20140350252A1 (en) 2011-02-21 2014-11-27 Nitin Maheshwari Process for the preparation of voriconazole and intermediates thereof
EP2720723B1 (en) 2011-06-15 2018-04-11 Synthon BV Stabilized voriconazole composition
CN102516233B (zh) * 2011-12-09 2014-04-09 北京联本医药化学技术有限公司 生产伏立康唑的方法
GR1007802B (el) * 2012-01-31 2013-01-18 Φαρματεν Αβεε, Μεθοδος για την παρασκευη παραγωγου της βρωμοπυρινιδινης
PL2906555T3 (pl) 2012-10-15 2017-07-31 Pfizer Ireland Pharmaceuticals Sposób wytwarzania worikonazolu i jego analogów
KR101435741B1 (ko) 2013-01-17 2014-08-29 (주) 에프엔지리서치 신규한 보리코나졸 중간체 및 이를 이용한 보리코나졸의 제조 방법
CN105503834B (zh) * 2015-12-23 2021-03-05 浙江华海药业股份有限公司 一种伏立康唑中间体的合成方法
CN106432198B (zh) * 2016-09-08 2022-10-21 浙江华海药业股份有限公司 一种制备伏立康唑拆分中间体的方法
CN106632267B (zh) * 2016-11-09 2019-02-22 中国科学院成都生物研究所 一种伏立康唑的合成方法
CN108276310A (zh) * 2017-01-06 2018-07-13 常州齐晖药业有限公司 一种伏立康唑拆分剂(r)-10-樟脑磺酸的回收方法
CN108586433A (zh) * 2017-07-21 2018-09-28 齐鲁工业大学 具有抗菌活性的伏立康唑盐酸盐
CN109705102A (zh) * 2019-02-19 2019-05-03 浙江华海立诚药业有限公司 伏立康唑及其中间体的制备方法
CN110305113A (zh) * 2019-07-05 2019-10-08 镇江市第四人民医院（镇江市妇幼保健院） 一种伏立康唑杂质b的合成方法
CN112442017A (zh) * 2019-08-29 2021-03-05 珠海润都制药股份有限公司 一种采用微通道反应器制备伏立康唑消旋体的方法
CN110724130A (zh) * 2019-11-29 2020-01-24 怀化学院 伏立康唑及其中间体的合成方法
CN111440152B (zh) * 2020-05-18 2022-09-27 浙江诚意药业股份有限公司 一种伏立康唑的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN112645935A (zh) * 2020-12-15 2021-04-13 植恩生物技术股份有限公司 伏立康唑关键中间体的制备方法
CN115724829A (zh) * 2022-12-23 2023-03-03 天津力生制药股份有限公司 一种分离真菌药物中间体杂质的液相色谱制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
EP0665225B1 (en) * 1994-02-01 1996-11-27 Ube Industries, Ltd. 4-Phenethylamino pyrimidine derivative, process for preparing the same and agricultural and horticultural chemical for controlling noxious organisms containing the same

Also Published As

Publication number Publication date
TR199800170T1 (xx) 1998-06-22
US20030181720A1 (en) 2003-09-25
WO1997006160A1 (en) 1997-02-20
HU224339B1 (hu) 2005-08-29
CN1076019C (zh) 2001-12-12
GB9516121D0 (en) 1995-10-04
KR100269048B1 (ko) 2000-10-16
PE16897A1 (es) 1997-05-21
CA2228655A1 (en) 1997-02-20
PL324922A1 (en) 1998-06-22
EG21200A (en) 2001-01-31
NO314938B1 (no) 2003-06-16
DE69631160T2 (de) 2004-07-08
AU703337B2 (en) 1999-03-25
DE69631160D1 (de) 2004-01-29
CA2228655C (en) 2003-09-09
CZ296975B6 (cs) 2006-08-16
NO980441D0 (no) 1998-02-02
HK1014944A1 (en) 1999-10-08
JP3224532B2 (ja) 2001-10-29
CN1195346A (zh) 1998-10-07
PT871625E (pt) 2004-04-30
BR9609960A (pt) 1999-02-02
JP2001354670A (ja) 2001-12-25
AU6740396A (en) 1997-03-05
EP0871625B1 (en) 2003-12-17
US6946555B2 (en) 2005-09-20
RU2156760C2 (ru) 2000-09-27
IL131521A0 (en) 2001-01-28
ES2210382T3 (es) 2004-07-01
IL122462A0 (en) 1998-06-15
KR19990036174A (ko) 1999-05-25
NO980441L (no) 1998-03-26
EP0871625A1 (en) 1998-10-21
MX9801025A (es) 1998-04-30
MY123062A (en) 2006-05-31
HUP9802766A2 (hu) 1999-02-01
JP2001026583A (ja) 2001-01-30
CZ32798A3 (cs) 1999-03-17
HUP9802766A3 (en) 2000-03-28
US6586594B1 (en) 2003-07-01
ATE256679T1 (de) 2004-01-15
PL187227B1 (pl) 2004-06-30
ZA966587B (en) 1998-02-02
NZ315651A (en) 1999-03-29
JPH10510549A (ja) 1998-10-13
IN190817B (da) 2003-08-23
AR003472A1 (es) 1998-08-05
TW442480B (en) 2001-06-23
IL131521A (en) 2001-08-08
JP3211965B2 (ja) 2001-09-25
IL122462A (en) 2001-10-31

Similar Documents

Publication Publication Date Title
DK0871625T3 (da) Fremstilling af triazoler ved organometallisk tilsætning af ketoner og mellemprodukter dertil
DE69608448D1 (de) Reduktion des biobewuchses
DK0706170T3 (da) Fremgangsmåde til talesyntese ved hjælp af sammenkædning og delvis overlapning af bølgeformer
DK0740972T3 (da) Støbning af stålbånd
DK0676744T3 (da) Estimering af exciteringsparametre
DK0721995T3 (da) Anvendelse af en jernbaseret legering til formstofforme
DE69615469D1 (de) Herstellung von Argon
ZA969429B (en) Amidinohydrazones of ketones
EE9900420A (et) Kõnesünteesi juurde kuuluv meetod
NO962940D0 (no) Fremgangsmåte ved hydroisomerisering
NO980862D0 (no) Zwitterinoformer av trovafloxacin
DK0982955T3 (da) Fremgangsmåde ved tildeling af telekommunikationstjenester
NO990018D0 (no) Belegg og fremgangsmÕte for fremstilling derav
KR960028244U (ko) 전기 취사기의 뚜껑
KR970000324U (ko) 조리용기의 손잡이
KR970007449U (ko) 전화기의 수신음량 조절장치
DK0747365T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af
KR960033460U (ko) 주철재 고기 구이판의 구조
MA23655A1 (fr) Perfectionnement des coffrages metalliques.
SE9502041D0 (sv) Provtagningsenhet och sätt att ta prover
KR960030348U (ko) 조리용기의 뚜껑
KR960002443U (ko) 마그네트론의 요크
KR960026652U (ko) 조리용기 손잡이의 구조
KR970026928U (ko) 냄비용 손잡이의 절첩 구조
KR950028037U (ko) 전자렌지의 전면 카바