GR1007802B - Μεθοδος για την παρασκευη παραγωγου της βρωμοπυρινιδινης - Google Patents
Μεθοδος για την παρασκευη παραγωγου της βρωμοπυρινιδινηςInfo
- Publication number
- GR1007802B GR1007802B GR20120100069A GR20120100069A GR1007802B GR 1007802 B GR1007802 B GR 1007802B GR 20120100069 A GR20120100069 A GR 20120100069A GR 20120100069 A GR20120100069 A GR 20120100069A GR 1007802 B GR1007802 B GR 1007802B
- Authority
- GR
- Greece
- Prior art keywords
- preparation
- bromopyrimidine
- derivative
- voriconazole
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά βελτιωμένη μέθοδο παρασκευής ενδιάμεσου προϊόντος βρωμοπυριμιδίνης του τύπου (IVa), το οποίο αποτελεί καίρια πρώτη ύλη για την μέθοδο παρασκευής Βορικοναζόλης του Τύπου (I) ή άλατος αυτής με προσθήκη οξέος και μέθοδο με χρήση ενός δοχείου (one-pot) για την παρασκευή χλωρο-Βορικοναζόλης.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20120100069A GR1007802B (el) | 2012-01-31 | 2012-01-31 | Μεθοδος για την παρασκευη παραγωγου της βρωμοπυρινιδινης |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20120100069A GR1007802B (el) | 2012-01-31 | 2012-01-31 | Μεθοδος για την παρασκευη παραγωγου της βρωμοπυρινιδινης |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1007802B true GR1007802B (el) | 2013-01-18 |
Family
ID=46582726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20120100069A GR1007802B (el) | 2012-01-31 | 2012-01-31 | Μεθοδος για την παρασκευη παραγωγου της βρωμοπυρινιδινης |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1007802B (el) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0871625A1 (en) * | 1995-08-05 | 1998-10-21 | Pfizer Research and Development Company, N.V./S.A. | Preparation of triazoles by organometallic addition to ketones and intermediates therefor |
CN102344441A (zh) * | 2010-07-25 | 2012-02-08 | 浙江华海药业股份有限公司 | 一种制备伏立康唑中间体的工艺改进方法 |
-
2012
- 2012-01-31 GR GR20120100069A patent/GR1007802B/el active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0871625A1 (en) * | 1995-08-05 | 1998-10-21 | Pfizer Research and Development Company, N.V./S.A. | Preparation of triazoles by organometallic addition to ketones and intermediates therefor |
CN102344441A (zh) * | 2010-07-25 | 2012-02-08 | 浙江华海药业股份有限公司 | 一种制备伏立康唑中间体的工艺改进方法 |
Non-Patent Citations (2)
Title |
---|
BUTTERS M ET AL: "Process Development of Voriconazole: A Novel Broad-Spectrum Triazole Antifungal Agent", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 5, 1 January 2001 (2001-01-01), pages 28 - 36, XP002504717, ISSN: 1083-6160, [retrieved on 20001121], DOI: 10.1021/OP0000879 * |
TONG, LIHUA, WANG LIYUAN, LI HONGZHAO: "synthesis of a novel antifungal drug voriconazole", ZHONGNAN YAOXUE, vol. 8, no. 4, 2010, pages 280 - 282, XP009162282, ISSN: 1672-2981 * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PG | Patent granted |
Effective date: 20130225 |