DK0859601T3 - Forlænget frigivelse af GM-CSF - Google Patents
Forlænget frigivelse af GM-CSFInfo
- Publication number
- DK0859601T3 DK0859601T3 DK96936356T DK96936356T DK0859601T3 DK 0859601 T3 DK0859601 T3 DK 0859601T3 DK 96936356 T DK96936356 T DK 96936356T DK 96936356 T DK96936356 T DK 96936356T DK 0859601 T3 DK0859601 T3 DK 0859601T3
- Authority
- DK
- Denmark
- Prior art keywords
- csf
- prolonged release
- hydrogel
- microparticle
- crosslinked
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Package Frames And Binding Bands (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/542,445 US5942253A (en) | 1995-10-12 | 1995-10-12 | Prolonged release of GM-CSF |
PCT/US1996/016277 WO1997013502A2 (en) | 1995-10-12 | 1996-10-10 | Prolonged release of gm-csf |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0859601T3 true DK0859601T3 (da) | 2005-01-24 |
Family
ID=24163868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96936356T DK0859601T3 (da) | 1995-10-12 | 1996-10-10 | Forlænget frigivelse af GM-CSF |
Country Status (10)
Country | Link |
---|---|
US (3) | US5942253A (da) |
EP (2) | EP1350518A1 (da) |
JP (2) | JPH11513667A (da) |
AT (1) | ATE275941T1 (da) |
AU (1) | AU714074B2 (da) |
DE (1) | DE69633399T2 (da) |
DK (1) | DK0859601T3 (da) |
ES (1) | ES2229286T3 (da) |
PT (1) | PT859601E (da) |
WO (1) | WO1997013502A2 (da) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US6406689B1 (en) | 1995-10-03 | 2002-06-18 | Frank W. Falkenberg | Compositions and methods for treatment of tumors and metastatic diseases |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
WO1997044016A1 (en) * | 1996-05-23 | 1997-11-27 | Samyang Corporation | Locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof |
KR0181252B1 (ko) * | 1996-12-31 | 1999-03-20 | 박원훈 | 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법 |
US20050074495A1 (en) * | 1997-06-17 | 2005-04-07 | Fziomed, Inc. | Compositions of polyacids and methods for their use in reducing adhesions |
US20040096422A1 (en) * | 1997-06-17 | 2004-05-20 | Schwartz Herbert E. | Compositions of polyacids and polyethers and methods for their use in reducing pain |
US6869938B1 (en) * | 1997-06-17 | 2005-03-22 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use in reducing adhesions |
US7192984B2 (en) * | 1997-06-17 | 2007-03-20 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use as dermal fillers |
WO1999009956A1 (en) * | 1997-08-29 | 1999-03-04 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
JP4467789B2 (ja) | 1997-09-18 | 2010-05-26 | パシラ ファーマシューティカルズ インコーポレーテッド | 持続放出性リポソーム麻酔組成物 |
IL135989A0 (en) * | 1997-11-14 | 2001-05-20 | Skyepharma Inc | Processes for the production of multivesicular liposomes |
US6730322B1 (en) | 1998-04-30 | 2004-05-04 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
BR9912070A (pt) * | 1998-07-13 | 2001-04-10 | Expression Genetics Inc | Análogo de poliéster de poli-l-lisina como um solúvel, veìculo de distribuição de gene biodegradável |
AU752225B2 (en) * | 1998-07-17 | 2002-09-12 | Pacira Pharmaceuticals, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
US6916490B1 (en) * | 1998-07-23 | 2005-07-12 | UAB Research Center | Controlled release of bioactive substances |
US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US6521431B1 (en) | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
EP1074248A1 (en) * | 1999-07-08 | 2001-02-07 | Arnold Hilgers | Delivery system for biological material |
US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
US6284235B1 (en) * | 2000-02-11 | 2001-09-04 | National Starch And Chemical Company Investment Holding Corporation | Bioadhesive composition |
AU4458401A (en) * | 2000-03-31 | 2001-10-15 | Kirin Brewery | Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
US6362308B1 (en) | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
US6911204B2 (en) * | 2000-08-11 | 2005-06-28 | Favrille, Inc. | Method and composition for altering a B cell mediated pathology |
EP1309373A2 (en) * | 2000-08-11 | 2003-05-14 | Favrille, Inc. | Method and composition for altering a t cell mediated pathology |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
AU2001294459A1 (en) | 2000-10-06 | 2002-04-15 | Jagotec Ag | A controlled-release, parenterally administrable microparticle preparation |
JP2004534721A (ja) | 2000-10-31 | 2004-11-18 | ピーアール ファーマシューティカルズ,インク. | 生理活性分子の向上した送達のための方法及び組成物 |
DE10055857A1 (de) * | 2000-11-10 | 2002-08-22 | Creative Peptides Sweden Ab Dj | Neue pharmazeutische Depotformulierung |
CZ20031559A3 (cs) * | 2000-12-13 | 2004-03-17 | Merckle Gmbh | Mikročástice se zlepšeným profilem uvolňování a způsob jejich výroby |
US6599627B2 (en) | 2000-12-13 | 2003-07-29 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
US20020114843A1 (en) * | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
US6652886B2 (en) * | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
EP1389467B1 (en) | 2001-05-23 | 2013-07-03 | Mitsubishi Tanabe Pharma Corporation | Therapeutic composition for the regenerative treatment of cartilage diseases |
US20040146561A1 (en) * | 2001-05-23 | 2004-07-29 | Naoki Sakurai | Compositions for promoting healing of bone fracture |
US20030124149A1 (en) * | 2001-07-06 | 2003-07-03 | Shalaby Shalaby W. | Bioactive absorbable microparticles as therapeutic vaccines |
US20030083286A1 (en) * | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
US20030124196A1 (en) * | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
CA2822457C (en) | 2001-12-14 | 2016-03-08 | The University Of Wyoming | Methods and compositions for controlled resease of drugs |
CA2472188C (en) * | 2002-01-18 | 2011-06-21 | Control Delivery Systems, Inc. | Polymeric gel system for the controlled delivery of codrugs |
US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
DE60335608D1 (de) * | 2002-02-27 | 2011-02-17 | Pharmain Corp | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
WO2003094887A1 (en) * | 2002-05-09 | 2003-11-20 | Peptron Co., Ltd | Sustained release formulation of protein and preparation method thereof |
US7037983B2 (en) | 2002-06-14 | 2006-05-02 | Kimberly-Clark Worldwide, Inc. | Methods of making functional biodegradable polymers |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
WO2004035086A2 (en) * | 2002-10-16 | 2004-04-29 | Hunter Samuel F | Method for treatment of demyelinating central nervous system disease using gm-csf |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
DK2599502T3 (da) | 2003-04-11 | 2017-04-18 | Antriabio Inc | Fremgangsmåde til fremstilling af stedspecifikke proteinkonjugater |
WO2004105799A1 (ja) * | 2003-05-29 | 2004-12-09 | Toudai Tlo, Ltd. | 安定化高分子ミセル |
GB0317999D0 (en) * | 2003-07-31 | 2003-09-03 | Univ Liege | Improvements in or relating to drug delivery systems |
US20070219117A1 (en) * | 2003-10-27 | 2007-09-20 | Medvet Science Pty Ltd | Bidentate motif and methods of use |
EP2409707B8 (en) * | 2004-04-15 | 2015-05-06 | Alkermes Pharma Ireland Limited | Polymer-based sustained release device |
EP1586334A1 (en) * | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF conjugates with peg |
MX2007000568A (es) * | 2004-07-16 | 2007-03-30 | Nektar Therapeutics Al Corp | Conjugados de una fraccion gm-csf y un polimero. |
EP1674077A1 (en) * | 2004-12-27 | 2006-06-28 | Université de Liège | Mucoadhesive pharmaceutical compositions comprising chemoattractants |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US9205046B2 (en) * | 2005-04-25 | 2015-12-08 | The Governing Council Of The University Of Toronto | Enhanced stability of inverse thermal gelling composite hydrogels |
JP2009503111A (ja) * | 2005-08-04 | 2009-01-29 | ネクター セラピューティックス エイエル,コーポレイション | G−csf部分および重合体の複合体 |
US20070081972A1 (en) * | 2005-09-30 | 2007-04-12 | The University Of Iowa Research Foundation | Polymer-based delivery system for immunotherapy of cancer |
US7585675B2 (en) * | 2005-11-15 | 2009-09-08 | University Of Kansas Medical Center | Inhibition of HIV and SHIV replication with antisense interleukin-4 |
US8226975B2 (en) | 2005-12-08 | 2012-07-24 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof |
JP2009520040A (ja) | 2005-12-19 | 2009-05-21 | ファーマイン コーポレーション | 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法 |
ITMI20061545A1 (it) * | 2006-08-02 | 2008-02-03 | Mediolanum Pharmaceuticals Ltd | Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo |
WO2008021133A2 (en) | 2006-08-09 | 2008-02-21 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
CA2680365A1 (en) * | 2007-03-22 | 2008-10-02 | Alkermes, Inc. | Coacervation process |
EP2157967B1 (en) | 2007-04-23 | 2013-01-16 | Intarcia Therapeutics, Inc | Suspension formulations of insulinotropic peptides and uses thereof |
WO2008137717A1 (en) * | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US20080317865A1 (en) * | 2007-06-20 | 2008-12-25 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
US20090176892A1 (en) | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
GB0814302D0 (en) * | 2008-08-05 | 2008-10-01 | Coretherapix Slu | Compounds and methods |
US20100189763A1 (en) * | 2009-01-23 | 2010-07-29 | Heather Nettles | Controlled release systems from polymer blends |
EP2396365A4 (en) * | 2009-02-11 | 2013-10-30 | Univ Houston | REDUCABLE POLYMERS FOR THE ADMINISTRATION OF NON-VIRAL GENES |
KR101233352B1 (ko) * | 2009-04-22 | 2013-02-25 | (주)비씨월드제약 | 유전자 재조합 과립구-대식세포 집락 촉진인자를 함유하는 정제 |
CN102458640B (zh) * | 2009-06-05 | 2016-11-23 | 新加坡南洋理工大学 | 多相微粒和生产多相微粒的方法 |
JP5376543B2 (ja) | 2009-07-01 | 2013-12-25 | 独立行政法人科学技術振興機構 | ポリイオンデンドリマー、及びそれよりなるハイドロゲル |
CN104323981B (zh) | 2009-09-28 | 2019-03-12 | 精达制药公司 | 基本稳态药物递送的快速建立和/或终止 |
CA2780274C (en) | 2009-11-09 | 2018-06-26 | Spotlight Technology Partners Llc | Fragmented hydrogels |
AU2010314992B2 (en) | 2009-11-09 | 2016-09-15 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
US8546353B2 (en) | 2010-05-06 | 2013-10-01 | Glykos Finland Oy | Compounds and combinations |
EP2384759A1 (en) * | 2010-05-06 | 2011-11-09 | Suomen Punainen Risti Veripalvelu | Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
EP4005576B1 (en) | 2012-05-21 | 2023-12-13 | Insmed Incorporated | Systems for treating pulmonary infections |
AU2013352259B2 (en) | 2012-11-29 | 2018-06-14 | Insmed Incorporated | Stabilized vancomycin formulations |
WO2015132392A1 (en) * | 2014-03-07 | 2015-09-11 | Reponex Pharmaceuticals Aps | Compositions for treating lung infections by airway administration |
US9895385B2 (en) | 2014-05-15 | 2018-02-20 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
EP3171887A1 (en) | 2014-07-24 | 2017-05-31 | Reponex Pharmaceuticals APS | Compositions comprising granulocyte-macrophage colony-stimulating factor for the treatment of inflammatory bowel disease |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
WO2016196851A2 (en) | 2015-06-03 | 2016-12-08 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
MX2018014016A (es) | 2016-05-16 | 2019-08-01 | Intarcia Therapeutics Inc | Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos. |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
JP7460534B2 (ja) | 2018-03-30 | 2024-04-02 | インスメッド インコーポレイテッド | リポソーム医薬品の連続製造方法 |
WO2020002650A1 (en) * | 2018-06-29 | 2020-01-02 | Targovax Asa | A formulation |
JP7383264B2 (ja) * | 2018-09-28 | 2023-11-20 | 株式会社カネカ | 樹脂組成物およびその成形体 |
DE102019126672B4 (de) * | 2019-10-02 | 2021-07-01 | Universität Rostock | Wirkstoffdepotsystem sowie Kit zur in situ Polymerisation des Wirkstoffdepotsystems |
CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1995970A (en) * | 1931-04-04 | 1935-03-26 | Du Pont | Polymeric lactide resin |
US2675945A (en) * | 1950-04-08 | 1954-04-20 | Milton K Hahn | Container for dispensing liquids |
US2676945A (en) * | 1950-10-18 | 1954-04-27 | Du Pont | Condensation polymers of hydroxyacetic acid |
US2683136A (en) * | 1950-10-25 | 1954-07-06 | Du Pont | Copolymers of hydroxyacetic acid with other alcohol acids |
US2703316A (en) * | 1951-06-05 | 1955-03-01 | Du Pont | Polymers of high melting lactide |
US2758987A (en) * | 1952-06-05 | 1956-08-14 | Du Pont | Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid |
DE1228416B (de) * | 1957-03-04 | 1966-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von Polyestern |
NL280825A (da) * | 1962-07-11 | |||
US3531561A (en) * | 1965-04-20 | 1970-09-29 | Ethicon Inc | Suture preparation |
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
US4272398A (en) * | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4542025A (en) * | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
RU2130493C1 (ru) | 1984-07-06 | 1999-05-20 | Новартис Аг | Способ получения белка с активностью gm-csf приматов |
US5795568A (en) | 1984-09-19 | 1998-08-18 | Novartis Corporation | Method of treating infectious disease with GM-CSF |
JP2551756B2 (ja) * | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
US5391485A (en) * | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
JPH0764742B2 (ja) | 1985-11-27 | 1995-07-12 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | Aids型疾患治療用組成物 |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US5162111A (en) | 1986-07-30 | 1992-11-10 | Grabstein Kenneth H | Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor |
US4929442A (en) | 1986-09-26 | 1990-05-29 | Exovir, Inc. | Compositions suitable for human topical application including a growth factor and/or related materials |
US5000886A (en) * | 1987-05-26 | 1991-03-19 | American Cyanamid Company | Silicone-hardened pharmaceutical microcapsules and process of making the same |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
ZA90600B (en) | 1989-01-30 | 1990-10-31 | Schering Corp | Treatment of leukocyte dysefunction with gm-csf |
JPH04504111A (ja) | 1989-03-17 | 1992-07-23 | ジェネティックス・インスティテュート・インコーポレイテッド | ヒトマクロファージ遊走阻止因子 |
FR2658432B1 (fr) * | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
US5478564A (en) * | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
AU1462392A (en) | 1991-02-22 | 1992-09-15 | Amgen, Inc. | Use of gm-csf and g-csf to promote accelerated wound healing |
US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
US5904920A (en) | 1991-10-04 | 1999-05-18 | Whitehead Institute For Biomedical Research | Regulation of systemic immune responses utilizing cytokines and antigens |
US5286495A (en) * | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
TNSN93075A1 (fr) * | 1992-07-08 | 1994-03-17 | Schering Corp | Utilisation de gm-csf comme adjuvant pour vaccin |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
IL110787A0 (en) * | 1993-08-27 | 1994-11-11 | Sandoz Ag | Biodegradable polymer, its preparation and pharmaceutical composition containing it |
US5591255A (en) * | 1993-12-29 | 1997-01-07 | Chromatic Technologies, Inc. | Thermochromic ink formulations, nail lacquer and methods of use |
DE4406172C2 (de) * | 1994-02-25 | 2003-10-02 | Sanol Arznei Schwarz Gmbh | Polyester |
US5478556A (en) | 1994-02-28 | 1995-12-26 | Elliott; Robert L. | Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor |
AUPM855194A0 (en) * | 1994-10-04 | 1994-10-27 | Csl Limited | Controlled-release pharmaceutical preparations |
US5691372A (en) | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
US5646180A (en) | 1995-12-05 | 1997-07-08 | Vertex Pharmaceuticals Incorporated | Treatment of the CNS effects of HIV |
-
1995
- 1995-10-12 US US08/542,445 patent/US5942253A/en not_active Expired - Fee Related
-
1996
- 1996-10-10 AU AU74384/96A patent/AU714074B2/en not_active Ceased
- 1996-10-10 DK DK96936356T patent/DK0859601T3/da active
- 1996-10-10 AT AT96936356T patent/ATE275941T1/de not_active IP Right Cessation
- 1996-10-10 WO PCT/US1996/016277 patent/WO1997013502A2/en active IP Right Grant
- 1996-10-10 JP JP9515216A patent/JPH11513667A/ja not_active Ceased
- 1996-10-10 DE DE69633399T patent/DE69633399T2/de not_active Expired - Fee Related
- 1996-10-10 PT PT96936356T patent/PT859601E/pt unknown
- 1996-10-10 EP EP03075970A patent/EP1350518A1/en not_active Withdrawn
- 1996-10-10 EP EP96936356A patent/EP0859601B1/en not_active Expired - Lifetime
- 1996-10-10 ES ES96936356T patent/ES2229286T3/es not_active Expired - Lifetime
-
1998
- 1998-11-03 US US09/185,213 patent/US6120807A/en not_active Expired - Fee Related
-
1999
- 1999-11-17 US US09/442,370 patent/US6274175B1/en not_active Expired - Fee Related
-
2007
- 2007-05-25 JP JP2007139387A patent/JP2007308500A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2007308500A (ja) | 2007-11-29 |
PT859601E (pt) | 2005-02-28 |
DE69633399D1 (de) | 2004-10-21 |
AU7438496A (en) | 1997-04-30 |
WO1997013502A3 (en) | 1997-10-02 |
WO1997013502A2 (en) | 1997-04-17 |
EP0859601B1 (en) | 2004-09-15 |
EP0859601A2 (en) | 1998-08-26 |
ATE275941T1 (de) | 2004-10-15 |
US6120807A (en) | 2000-09-19 |
JPH11513667A (ja) | 1999-11-24 |
US6274175B1 (en) | 2001-08-14 |
AU714074B2 (en) | 1999-12-16 |
US5942253A (en) | 1999-08-24 |
ES2229286T3 (es) | 2005-04-16 |
DE69633399T2 (de) | 2005-10-27 |
EP1350518A1 (en) | 2003-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0859601T3 (da) | Forlænget frigivelse af GM-CSF | |
DK0728826T3 (da) | Sammensætninger omfattende en acrylamidholdig polymer samt anvendelse | |
ES2084722T3 (es) | Composicion para tratamiento del ojo seco. | |
GR3021234T3 (en) | Particulate, absorbent, polymeric compositions containing interparticle crosslinked aggregates | |
DE09004973T8 (de) | Formulierung mit gesteuerter Freisetzung | |
ES2056684T3 (es) | Barras cosmeticas claras con componentes compatibles de fragancia. | |
DE69403985D1 (de) | In Wasser dispergierte Harzzusammensetzung | |
CA2222359A1 (fr) | Composition cosmetique comprenant l'association d'un polymere filmogene et d'une dispersion de cire et utilisation de ladite association | |
NO964539D0 (no) | Kollagen-preparat for kontrollert avgivelse av virkestoffer | |
IT1276210B1 (it) | Composizione stabilizzante per materiali polimerici | |
DE69307792D1 (de) | Vulkanisierbare Organopolysiloxan-Zusammensetzung | |
DE69124589D1 (de) | Härtbare Organopolysiloxanzusammensetzung mit konstanten Entformungseigenschaften | |
WO1999017711A3 (en) | Autophobic hairspray compositions | |
ITMI931641A0 (it) | Catalizzatore bifunzionale efficace4 nella idroisomerizzazione di ceree procedimento per la preparazione | |
ES2046852T3 (es) | Un procedimiento para preparar un champu. | |
FI882239A (fi) | Slaeckvattentillsats | |
ES2091867T3 (es) | Diamidas alquilicas y composiciones para el tratamiento cosmetico a base de estas. | |
ES530411A0 (es) | Procedimiento para preparar composiciones polimericas vulcanizables conteniendo dimetacrilato de zinc y cargas. | |
BR9503900A (pt) | Composição polimérica útil como um antioxidante | |
IT1237994B (it) | Composizione stabilizzante per polimeri del vinilcloruro e composizioni polimeriche contenenti la stessa | |
FR2722094B1 (fr) | Composition orale pour reactiver le bronzage de lapeau a base d'un carotenoide et d'un tocopherol | |
FI932595A0 (fi) | En vattenhaltig, polymerisk, viskositet upphoejande komposition | |
DE59301126D1 (de) | Wässrige Polymerisatzubereitungen | |
ITMI941050A0 (it) | Composizioni per la stabilizzazione di polimeri sintetici | |
IT220339Z2 (it) | Freno per stoppino nelle spole da banco |