DK0804246T3 - Mitomycinholdige lægemiddelleveringssystemer - Google Patents

Mitomycinholdige lægemiddelleveringssystemer

Info

Publication number
DK0804246T3
DK0804246T3 DK94923825T DK94923825T DK0804246T3 DK 0804246 T3 DK0804246 T3 DK 0804246T3 DK 94923825 T DK94923825 T DK 94923825T DK 94923825 T DK94923825 T DK 94923825T DK 0804246 T3 DK0804246 T3 DK 0804246T3
Authority
DK
Denmark
Prior art keywords
mmc
pct
groups
carrier polymer
spacer
Prior art date
Application number
DK94923825T
Other languages
Danish (da)
English (en)
Inventor
Etienne Honore Schacht
Paolo Ferruti
Ruth Duncan
Original Assignee
Europ Economic Community
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europ Economic Community filed Critical Europ Economic Community
Application granted granted Critical
Publication of DK0804246T3 publication Critical patent/DK0804246T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94923825T 1993-08-18 1994-08-17 Mitomycinholdige lægemiddelleveringssystemer DK0804246T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9317213A GB2282384B8 (en) 1993-08-18 1993-08-18 Drug delivery agents incorporating mitomycin
PCT/IB1994/000259 WO1995005200A1 (en) 1993-08-18 1994-08-17 Drug delivery agents incorporating mitomycin

Publications (1)

Publication Number Publication Date
DK0804246T3 true DK0804246T3 (da) 2000-11-13

Family

ID=10740702

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94923825T DK0804246T3 (da) 1993-08-18 1994-08-17 Mitomycinholdige lægemiddelleveringssystemer

Country Status (12)

Country Link
US (1) US5738864A (ja)
EP (1) EP0804246B1 (ja)
JP (1) JPH09501674A (ja)
AT (1) ATE192933T1 (ja)
CA (1) CA2168007C (ja)
DE (1) DE69424577T2 (ja)
DK (1) DK0804246T3 (ja)
ES (1) ES2145832T3 (ja)
GB (1) GB2282384B8 (ja)
GR (1) GR3034174T3 (ja)
PT (1) PT804246E (ja)
WO (1) WO1995005200A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5850855A (en) * 1990-01-09 1998-12-22 Ems-Inventa Ag Flexible coolant conduit and method of making same
BR9811252A (pt) * 1997-02-26 2000-09-26 Lilly Co Eli Processo para preparação de compostos farmacêuticos
US6251866B1 (en) 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
ID29943A (id) * 1998-10-30 2001-10-25 Daiichi Seiyaku Co Senyawa dds dan metode pengukurannya
AU2001288829A1 (en) * 2000-09-06 2002-03-22 Ap Pharma, Inc. Degradable polyacetal polymers
WO2003017938A2 (en) * 2001-08-22 2003-03-06 Watson Pharmaceuticals, Inc. Conjugates targeted to target receptors
AU2004233997C1 (en) * 2003-04-29 2014-01-30 Massachusetts Institiute Of Technology Methods and devices for the sustained release of multiple drugs
US7812051B2 (en) 2004-08-11 2010-10-12 Arqule, Inc. Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
ATE465205T1 (de) 2005-12-05 2010-05-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
JP5286822B2 (ja) * 2007-02-22 2013-09-11 Ｊｓｒ株式会社 ポリアミノ酸またはポリアミノ酸系共重合体の製造方法
CN104800856A (zh) * 2007-04-10 2015-07-29 日东电工株式会社 多功能聚谷氨酸盐药物载体
WO2008134088A1 (en) 2007-04-30 2008-11-06 Arqule, Inc. Hydroxy sulfonate of quinone compounds and their uses
WO2008141110A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
PT2155255E (pt) 2007-05-09 2013-10-15 Nitto Denko Corp Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido
RU2010137032A (ru) * 2008-03-06 2012-04-20 Нитто Денко Корпорейшн (Jp) Конъюгаты паклитаксела с полимером и способы лечения рака
EP3655039A1 (en) * 2017-07-17 2020-05-27 Technische Universiteit Eindhoven Applicable chemical composition comprising an agent conjugated to a hydrophobic moiety and a carrier

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1541436A (en) * 1976-02-02 1979-02-28 Searle & Co Immunological materials
JP2528477B2 (ja) * 1987-09-07 1996-08-28 三共株式会社 高分子制癌剤の増強剤
KR900701269A (ko) * 1988-08-23 1990-12-01 원본미기재 골수독성이 낮은 미토마이신 유도체, 그 제조방법 및 그이용
JPH0762049B2 (ja) * 1991-03-18 1995-07-05 工業技術院長 高分子マイトマイシンｃ誘導体及びその製造方法
JPH05252673A (ja) * 1992-03-05 1993-09-28 Honda Motor Co Ltd 電源装置

Also Published As

Publication number Publication date
EP0804246B1 (en) 2000-05-17
GB2282384A (en) 1995-04-05
DE69424577T2 (de) 2001-02-22
DE69424577D1 (de) 2000-06-21
CA2168007A1 (en) 1995-02-23
CA2168007C (en) 2001-06-12
EP0804246A1 (en) 1997-11-05
GB2282384B (en) 1997-09-03
JPH09501674A (ja) 1997-02-18
ATE192933T1 (de) 2000-06-15
GB9317213D0 (en) 1993-10-06
GR3034174T3 (en) 2000-11-30
GB2282384B8 (en) 1997-09-04
US5738864A (en) 1998-04-14
ES2145832T3 (es) 2000-07-16
PT804246E (pt) 2000-08-31
WO1995005200A1 (en) 1995-02-23

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