DE69420574T2 - Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen - Google Patents

Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen

Info

Publication number
DE69420574T2
DE69420574T2 DE69420574T DE69420574T DE69420574T2 DE 69420574 T2 DE69420574 T2 DE 69420574T2 DE 69420574 T DE69420574 T DE 69420574T DE 69420574 T DE69420574 T DE 69420574T DE 69420574 T2 DE69420574 T2 DE 69420574T2
Authority
DE
Germany
Prior art keywords
same
cascade
derivatives
production
therapeutically effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69420574T
Other languages
English (en)
Other versions
DE69420574D1 (de
Inventor
Jean-Luc Fauchere
Christophe Thurieau
Tony Verbeuren
Alain Rupin
Serge Simonet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69420574D1 publication Critical patent/DE69420574D1/de
Publication of DE69420574T2 publication Critical patent/DE69420574T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69420574T 1993-10-07 1994-10-06 Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen Expired - Fee Related DE69420574T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311942A FR2710917B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1994/001166 WO1995009869A1 (fr) 1993-10-07 1994-10-06 Nouveaux derives de peptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE69420574D1 DE69420574D1 (de) 1999-10-14
DE69420574T2 true DE69420574T2 (de) 2000-05-04

Family

ID=9451616

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420574T Expired - Fee Related DE69420574T2 (de) 1993-10-07 1994-10-06 Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen

Country Status (16)

Country Link
US (1) US5786330A (de)
EP (1) EP0722460B1 (de)
JP (1) JP2899415B2 (de)
CN (1) CN1053451C (de)
AT (1) ATE184287T1 (de)
AU (1) AU680696B2 (de)
CA (1) CA2173598A1 (de)
DE (1) DE69420574T2 (de)
DK (1) DK0722460T3 (de)
ES (1) ES2138668T3 (de)
FI (1) FI961505A (de)
FR (1) FR2710917B1 (de)
GR (1) GR3031254T3 (de)
NO (1) NO961357L (de)
NZ (1) NZ274524A (de)
WO (1) WO1995009869A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1138694A1 (de) * 2000-03-30 2001-10-04 University Of Manitoba Hirulog-ähnliches Peptid
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686086A1 (fr) * 1992-01-15 1993-07-16 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
EP0722460B1 (de) 1999-09-08
CN1134706A (zh) 1996-10-30
NO961357D0 (no) 1996-04-02
AU680696B2 (en) 1997-08-07
US5786330A (en) 1998-07-28
FR2710917B1 (fr) 1995-11-24
FI961505A0 (fi) 1996-04-03
CA2173598A1 (fr) 1995-04-13
CN1053451C (zh) 2000-06-14
ATE184287T1 (de) 1999-09-15
NO961357L (no) 1996-06-06
WO1995009869A1 (fr) 1995-04-13
GR3031254T3 (en) 1999-12-31
NZ274524A (en) 1996-12-20
JPH09503221A (ja) 1997-03-31
ES2138668T3 (es) 2000-01-16
AU7858794A (en) 1995-05-01
DK0722460T3 (da) 2000-03-20
JP2899415B2 (ja) 1999-06-02
FR2710917A1 (fr) 1995-04-14
FI961505A (fi) 1996-04-03
EP0722460A1 (de) 1996-07-24
DE69420574D1 (de) 1999-10-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

8339 Ceased/non-payment of the annual fee