FR2710917B1 - Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. - Google Patents

Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Info

Publication number
FR2710917B1
FR2710917B1 FR9311942A FR9311942A FR2710917B1 FR 2710917 B1 FR2710917 B1 FR 2710917B1 FR 9311942 A FR9311942 A FR 9311942A FR 9311942 A FR9311942 A FR 9311942A FR 2710917 B1 FR2710917 B1 FR 2710917B1
Authority
FR
France
Prior art keywords
pharmaceutical compositions
preparation process
compositions containing
blood coagulation
therapeutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9311942A
Other languages
English (en)
French (fr)
Other versions
FR2710917A1 (fr
Inventor
Jean-Luc Fauchere
Christophe Thurieau
Tony Verbeuren
Alain Rupin
Serge Simonet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9311942A priority Critical patent/FR2710917B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to AT94929585T priority patent/ATE184287T1/de
Priority to DK94929585T priority patent/DK0722460T3/da
Priority to US08/619,683 priority patent/US5786330A/en
Priority to CA002173598A priority patent/CA2173598A1/fr
Priority to AU78587/94A priority patent/AU680696B2/en
Priority to CN94194052A priority patent/CN1053451C/zh
Priority to PCT/FR1994/001166 priority patent/WO1995009869A1/fr
Priority to DE69420574T priority patent/DE69420574T2/de
Priority to EP94929585A priority patent/EP0722460B1/de
Priority to JP7510650A priority patent/JP2899415B2/ja
Priority to ES94929585T priority patent/ES2138668T3/es
Priority to NZ274524A priority patent/NZ274524A/en
Publication of FR2710917A1 publication Critical patent/FR2710917A1/fr
Application granted granted Critical
Publication of FR2710917B1 publication Critical patent/FR2710917B1/fr
Priority to NO961357A priority patent/NO961357L/no
Priority to FI961505A priority patent/FI961505A/fi
Priority to GR990402347T priority patent/GR3031254T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR9311942A 1993-10-07 1993-10-07 Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. Expired - Fee Related FR2710917B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR9311942A FR2710917B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JP7510650A JP2899415B2 (ja) 1993-10-07 1994-10-06 血液凝固のカスケードにおいて治療上活性である新規ペプチド誘導体、その製造方法、及びそれらを含有する医薬組成物
US08/619,683 US5786330A (en) 1993-10-07 1994-10-06 Peptide compounds which are therapeutically active in the cascade of blood coagulation, process for preparing them and pharmaceutical compositions containing them
CA002173598A CA2173598A1 (fr) 1993-10-07 1994-10-06 Nouveaux derives de peptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU78587/94A AU680696B2 (en) 1993-10-07 1994-10-06 Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same
CN94194052A CN1053451C (zh) 1993-10-07 1994-10-06 在凝血反应中有治疗活性的新型肽化合物,其制备方法及其药物组合物
PCT/FR1994/001166 WO1995009869A1 (fr) 1993-10-07 1994-10-06 Nouveaux derives de peptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69420574T DE69420574T2 (de) 1993-10-07 1994-10-06 Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen
AT94929585T ATE184287T1 (de) 1993-10-07 1994-10-06 Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen
DK94929585T DK0722460T3 (da) 1993-10-07 1994-10-06 Peptidderivater der er terapeutisk aktive i blodkoaguleringskaskaden, fremgangsmåde til fremstilling heraf og farmaceutiske
ES94929585T ES2138668T3 (es) 1993-10-07 1994-10-06 Nuevos derivados de peptidos terapeuticamente activos en la cadena de coagulacion sanguinea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
NZ274524A NZ274524A (en) 1993-10-07 1994-10-06 Peptides therapeutically active in the blood coagulation cascade
EP94929585A EP0722460B1 (de) 1993-10-07 1994-10-06 Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen
NO961357A NO961357L (no) 1993-10-07 1996-04-02 Nye terapeutisk aktive peptidforbindelser i blodkoagulasjonskaskaden, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
FI961505A FI961505A (fi) 1993-10-07 1996-04-03 Uudet veren koaguloitumisjärjestelmässä terapeuttisesti aktiiviset peptidiyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
GR990402347T GR3031254T3 (en) 1993-10-07 1999-09-20 Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9311942A FR2710917B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
FR2710917A1 FR2710917A1 (fr) 1995-04-14
FR2710917B1 true FR2710917B1 (fr) 1995-11-24

Family

ID=9451616

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9311942A Expired - Fee Related FR2710917B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Country Status (16)

Country Link
US (1) US5786330A (de)
EP (1) EP0722460B1 (de)
JP (1) JP2899415B2 (de)
CN (1) CN1053451C (de)
AT (1) ATE184287T1 (de)
AU (1) AU680696B2 (de)
CA (1) CA2173598A1 (de)
DE (1) DE69420574T2 (de)
DK (1) DK0722460T3 (de)
ES (1) ES2138668T3 (de)
FI (1) FI961505A (de)
FR (1) FR2710917B1 (de)
GR (1) GR3031254T3 (de)
NO (1) NO961357L (de)
NZ (1) NZ274524A (de)
WO (1) WO1995009869A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1138694A1 (de) * 2000-03-30 2001-10-04 University Of Manitoba Hirulog-ähnliches Peptid
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686086A1 (fr) * 1992-01-15 1993-07-16 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ATE184287T1 (de) 1999-09-15
NZ274524A (en) 1996-12-20
JP2899415B2 (ja) 1999-06-02
AU7858794A (en) 1995-05-01
EP0722460B1 (de) 1999-09-08
AU680696B2 (en) 1997-08-07
CN1053451C (zh) 2000-06-14
NO961357D0 (no) 1996-04-02
CN1134706A (zh) 1996-10-30
DK0722460T3 (da) 2000-03-20
ES2138668T3 (es) 2000-01-16
NO961357L (no) 1996-06-06
JPH09503221A (ja) 1997-03-31
DE69420574T2 (de) 2000-05-04
CA2173598A1 (fr) 1995-04-13
FI961505A0 (fi) 1996-04-03
EP0722460A1 (de) 1996-07-24
US5786330A (en) 1998-07-28
FI961505A (fi) 1996-04-03
FR2710917A1 (fr) 1995-04-14
DE69420574D1 (de) 1999-10-14
WO1995009869A1 (fr) 1995-04-13
GR3031254T3 (en) 1999-12-31

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Legal Events

Date Code Title Description
ER Errata listed in the french official journal (bopi)

Free format text: 15/95

ST Notification of lapse