NO961357L - Nye terapeutisk aktive peptidforbindelser i blodkoagulasjonskaskaden, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem - Google Patents

Nye terapeutisk aktive peptidforbindelser i blodkoagulasjonskaskaden, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem

Info

Publication number
NO961357L
NO961357L NO961357A NO961357A NO961357L NO 961357 L NO961357 L NO 961357L NO 961357 A NO961357 A NO 961357A NO 961357 A NO961357 A NO 961357A NO 961357 L NO961357 L NO 961357L
Authority
NO
Norway
Prior art keywords
preparation
methods
pharmaceutical compositions
compositions containing
blood coagulation
Prior art date
Application number
NO961357A
Other languages
English (en)
Other versions
NO961357D0 (no
Inventor
Jean-Luc Fauchere
Christophe Thurieau
Tony Verbeuren
Alain Rupin
Serge Simonet
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of NO961357D0 publication Critical patent/NO961357D0/no
Publication of NO961357L publication Critical patent/NO961357L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Oppfinnelsen vedrører forbindelsene med formel (I): H-phe-Ai-Arg-Pro- (Gly)4-Aan-Gly-ABp-Phe-Glu- Abo-Ile-Pro-Glu-Glu-Aj-Leu-glu-OH (D hvor: Aj representerer en prolinrest (Pro), oktahydroin- dol-2-carbonyl (Oic), 2-azabicyklo[2.2. l]hep- tan-3-karbonyl (Abh) eller 2-azabicyklo[2.2.2] - oktan-3-karbonyl (Abo), Aj representerer en fenylalaninrest substituert i para- eller i meta-stilling med en gruppe POjH2 (Phe (pP03H2) , Phe (mPO3H2)) , deres addisjonssalter med en farmasøytisk akseptabel syre eller base, idet hver aminosyre i peptidsek- vensen er optisk ren, og a-karbonatomet i hver ami- nosyre har D- eller L-konfigurasjon. Medikamenter.
NO961357A 1993-10-07 1996-04-02 Nye terapeutisk aktive peptidforbindelser i blodkoagulasjonskaskaden, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem NO961357L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311942A FR2710917B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1994/001166 WO1995009869A1 (fr) 1993-10-07 1994-10-06 Nouveaux derives de peptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
NO961357D0 NO961357D0 (no) 1996-04-02
NO961357L true NO961357L (no) 1996-06-06

Family

ID=9451616

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961357A NO961357L (no) 1993-10-07 1996-04-02 Nye terapeutisk aktive peptidforbindelser i blodkoagulasjonskaskaden, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem

Country Status (16)

Country Link
US (1) US5786330A (no)
EP (1) EP0722460B1 (no)
JP (1) JP2899415B2 (no)
CN (1) CN1053451C (no)
AT (1) ATE184287T1 (no)
AU (1) AU680696B2 (no)
CA (1) CA2173598A1 (no)
DE (1) DE69420574T2 (no)
DK (1) DK0722460T3 (no)
ES (1) ES2138668T3 (no)
FI (1) FI961505A (no)
FR (1) FR2710917B1 (no)
GR (1) GR3031254T3 (no)
NO (1) NO961357L (no)
NZ (1) NZ274524A (no)
WO (1) WO1995009869A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1138694A1 (en) * 2000-03-30 2001-10-04 University Of Manitoba Hirulog-like peptide
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686086A1 (fr) * 1992-01-15 1993-07-16 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ATE184287T1 (de) 1999-09-15
NZ274524A (en) 1996-12-20
JP2899415B2 (ja) 1999-06-02
AU7858794A (en) 1995-05-01
EP0722460B1 (fr) 1999-09-08
AU680696B2 (en) 1997-08-07
CN1053451C (zh) 2000-06-14
NO961357D0 (no) 1996-04-02
CN1134706A (zh) 1996-10-30
DK0722460T3 (da) 2000-03-20
ES2138668T3 (es) 2000-01-16
FR2710917B1 (fr) 1995-11-24
JPH09503221A (ja) 1997-03-31
DE69420574T2 (de) 2000-05-04
CA2173598A1 (fr) 1995-04-13
FI961505A0 (fi) 1996-04-03
EP0722460A1 (fr) 1996-07-24
US5786330A (en) 1998-07-28
FI961505A (fi) 1996-04-03
FR2710917A1 (fr) 1995-04-14
DE69420574D1 (de) 1999-10-14
WO1995009869A1 (fr) 1995-04-13
GR3031254T3 (en) 1999-12-31

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application